{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:10:47Z","timestamp":1740179447513,"version":"3.37.3"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background\u2003<\/jats:title>\n                  <jats:p>Raynaud\u2019s syndrome is a commonly encountered disorder. The relationship between the grade of Raynaud\u2019s phenomenon and severity of vasoconstriction is unclear. Recently, various methods including colour Doppler ultrasonography have been used for assessment of vascularity of the extremities including fingers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary\u2003<\/jats:title>\n                  <jats:p>A 53-year-old man had a 6-year history of Raynaud\u2019s phenomenon with typical tri-coloured changes proceeding from white, blue to red and slight pain and slight paresthaesia in the fingers of both hands when his fingers were exposed to cold. He was diagnosed with primary Raynaud\u2019s syndrome. After treatment with the calcium channel blocker amlodipine (5\u2009mg once daily), a cold challenge did not induce Raynaud\u2019s phenomenon on the fingers in the present patient. After the cold challenge, colour Doppler ultrasonography showed that vascularity was markedly decreased or was absent, whereas there was little difference in skin colour of the fingers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion\u2003<\/jats:title>\n                  <jats:p>In Raynaud's phenomenon, vasospasm may occur even if the symptoms are well-controlled with a calcium channel blocker. It is unlikely that clinical symptoms in patients with Raynaud\u2019s syndrome always reflect the severity of vasoconstriction in their fingers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa394","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T03:57:16Z","timestamp":1606881436000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Finger blood flow after the cold challenge with primary Raynaud\u2019s syndrome: a case report"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-1253","authenticated-orcid":false,"given":"Yuichi","family":"Fujii","sequence":"first","affiliation":[{"name":"Department of Medicine and Molecular Science, Hiroshima University Graduate School of Medical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5813-3672","authenticated-orcid":false,"given":"Yukihito","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"volume-title":"On Local Asphyxia and Symmetrical Gangrene of Extremities","year":"1888","author":"Raynaud","key":"2021010812224384200_ytaa394-B1"},{"key":"2021010812224384200_ytaa394-B2","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1056\/NEJMra1507638","article-title":"Raynaud\u2019s Phenomenon","volume":"375","author":"Wigley","year":"2016","journal-title":"N Engl J Med"},{"key":"2021010812224384200_ytaa394-B3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/rheumatology\/keh552","article-title":"Pathogenesis of Raynaud's phenomenon","volume":"44","author":"Herrick","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"2021010812224384200_ytaa394-B4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/ard.57.2.70","article-title":"Quantifying digital vascular disease in patients with primary Raynaud\u2019s phenomenon and systemic sclerosis","volume":"57","author":"Herrick","year":"1998","journal-title":"Ann Rheum Dis"},{"key":"2021010812224384200_ytaa394-B5","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/rheumatology\/39.11.1206","article-title":"Assessment of microvascular changes in Raynaud's phenomenon and connective tissue disease using colour Doppler ultrasound","volume":"39","author":"Keberle","year":"2000","journal-title":"Rheumatology (Oxford)"},{"key":"2021010812224384200_ytaa394-B6","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1016\/j.jacc.2010.07.071","article-title":"Color Doppler flows of corkscrew collaterals in thromboangiitis obliterans (Buerger disease) using color duplex ultrasonography","volume":"57","author":"Fujii","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2021010812224384200_ytaa394-B7","first-page":"CD002069","article-title":"Calcium channel blockers for primary Raynaud\u2019s phenomenon","volume":"2","author":"Ennis","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2021010812224384200_ytaa394-B8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3109\/10739689709146797","article-title":"The cutaneous microcirculation: ultrastructure and microanatomical organization","volume":"4","author":"Braverman","year":"1997","journal-title":"Microcirculation"},{"key":"2021010812224384200_ytaa394-B9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1113\/jphysiol.1962.sp006933","article-title":"Cold-induced vasodilatation in various areas of the body surface of man","volume":"162","author":"Fox","year":"1962","journal-title":"J Physiol"},{"key":"2021010812224384200_ytaa394-B10","doi-asserted-by":"crossref","first-page":"e013915","DOI":"10.1161\/JAHA.119.013915","article-title":"Diagnostic criteria of flow-mediated vasodilation for normal endothelial function and nitroglycerine-induced vasodilation for normal vascular smooth muscle function of the brachial artery","volume":"9","author":"Maruhashi","year":"2020","journal-title":"J Am Heart Assoc"}],"container-title":["European Heart Journal - 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