{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:10:45Z","timestamp":1740179445802,"version":"3.37.3"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T00:00:00Z","timestamp":1607212800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background\u2003<\/jats:title>\n                  <jats:p>Active infection is generally considered a contraindication for heart transplantation. The rare combination of a patient with an active Coxiella burnetii infection and a congenital corrected transposition of the great arteries requiring heart transplantation impose challenging treatment decisions. We would like to demonstrate that if Q fever is restricted to the heart only, heart transplantation is also beneficial from an infectious point of view, therefore treating two severe conditions simultaneously.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary\u2003<\/jats:title>\n                  <jats:p>A patient with end-stage heart failure due to congenital corrected transposition of the great arteries and requiring heart transplantation developed chronic Q fever and endocarditis. Different antibiotic regimes were tried due to severe adverse reactions. Antibiotic treatment was precisely monitored by measuring Q fever polymerase chain reaction (PCRs) and phase I IgG antibody titres. A positron emission tomography scan revealed that Q fever was confined to the heart only after which it was decided to perform heart transplantation. Based on the results of PCR and antibody testing, antibiotic treatment was stopped after 1 year. After 5\u2009years of follow-up, patient is still in an optimal condition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion\u2003<\/jats:title>\n                  <jats:p>In case of a patient with end-stage heart failure and chronic Q fever, a combined treatment with PCR-\/antibody monitored antibiotics and heart transplantation can cure both conditions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa435","type":"journal-article","created":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T07:23:44Z","timestamp":1607239424000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Heart transplantation for end-stage heart failure combined with Q fever isolated to the heart: a case report"],"prefix":"10.1093","volume":"4","author":[{"given":"Marcel","family":"van \u2018t Veer","sequence":"first","affiliation":[{"name":"Department of Cardiology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8510-8648","authenticated-orcid":false,"given":"Luuk","family":"Otterspoor","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2798-9122","authenticated-orcid":false,"given":"Marieke","family":"de Regt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091 AC, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathinka","family":"Peels","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jola","family":"evens","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aryan","family":"Vink","sequence":"additional","affiliation":[{"name":"Department of pathology, University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6457-1425","authenticated-orcid":false,"given":"Nicolaas","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"key":"2021010812225038300_ytaa435-B1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1537-2995.2011.03250.x","article-title":"Coxiella burnetii infection among blood donors during the 2009 Q-fever outbreak in the Netherlands","volume":"52","author":"Hogema","year":"2012","journal-title":"Transfusion"},{"key":"2021010812225038300_ytaa435-B2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1128\/CMR.00045-16","article-title":"From Q fever to Coxiella burnetii infection: a paradigm change","volume":"30","author":"Eldin","year":"2017","journal-title":"Clin Microbiol Rev"},{"key":"2021010812225038300_ytaa435-B3","doi-asserted-by":"crossref","first-page":"371.e1","DOI":"10.1016\/j.cmi.2014.11.027","article-title":"Heart transplantation as salvage treatment of intractable infective endocarditis","volume":"21","author":"Aymami","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"2021010812225038300_ytaa435-B4","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/0003-4975(94)91688-8","article-title":"Heart transplantation for Q fever endocarditis","volume":"58","author":"Blanche","year":"1994","journal-title":"Ann Thorac Surg"}],"container-title":["European Heart Journal - 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