{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:47Z","timestamp":1753876247190,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Bicuspid aortic valve is the most common congenital cardiovascular malformation and occurs in 1\u20132% of the population. The haemodynamic changes appear early, leading to tissue damage and predisposing to germs attachment. The development of perivalvular extension is a constant in bicuspid aortic valve endocarditis. Infective endocarditis with anaerobic bacteria is a rare condition with a high rate of mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We report a case of a young female with bicuspid aortic valve infective endocarditis. Involved bacteria were anaerobic streptococci, and the clinical course of the diseases was very aggressive. The echocardiographic evaluation revealed aortic and mitral regurgitation, perivalvular abscess, ventricular septum defect, and pericardial effusion. The surgery approach consisted of the aortic valve replacement with a mechanical prosthesis after radical resection of aortic root abscess and reconstruction of the annulus. The ventricular septum defect was also closed with a pericardial patch. Anticoagulation started the first day after surgery. The patient was received antibiotic therapy for 10 days before and 4 weeks after surgical intervention. Evolution was very good at 1 and 6 months follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This is a severe case of endocarditis, complicated with extensive valvular destruction, aortic root abscess, and fistula. Perivalvular complications are frequent in patients with bicuspid aortic valve endocarditis. The \u2018take away\u2019 message is that echocardiography is an essential tool for diagnosis, management, and follow-up of patients with infective endocarditis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa452","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T09:29:31Z","timestamp":1608024571000},"source":"Crossref","is-referenced-by-count":0,"title":["A rare case of anaerobic streptococci endocarditis in a young female with bicuspid aortic valve: case report"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-216X","authenticated-orcid":false,"given":"Despina","family":"Toader","sequence":"first","affiliation":[{"name":"Department of Cardiology, Craiova Cardiology Center, EuroEchoLab, Str Tabaci nr1, Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mioara","family":"Cocora","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Department, Institute of Cardiovascular Disease, Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin","family":"B\u0103t\u0103iosu","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Craiova Cardiology Center, Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4715-8350","authenticated-orcid":false,"given":"Lumini\u0103","family":"Ocroteal\u0103","sequence":"additional","affiliation":[{"name":"Department of Hematology, Municipal Hospital Craiova, Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"2021062103184622100_ytaa452-B1","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.CIR.0000027905.26586.E8","article-title":"Clinical and pathophysiological implications of a bicuspid aortic 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