{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:44:39Z","timestamp":1781243079629,"version":"3.54.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Respiratory failure is a life-threatening complication of coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome. Extracorporeal membrane oxygenation (ECMO) in COVID-19 might offer promise based on our clinical experience. However, few critically ill cases with COVID-19 have been weaned off ECMO.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 66-year-old Chinese woman presented with fever (38.9\u00b0C), cough, dyspnoea, and headache. She had lymphopenia (0.72\u2009\u00d7\u2009109\/L) and computed tomography findings of ground-glass opacities. Subsequently, she was confirmed to have respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. She was intubated after transfer to the intensive care unit due to respiratory failure and heart failure. However, her condition continued to deteriorate rapidly. Veno-veno ECMO was undertaken for respiratory and cardiac support due to refractory hypoxemic respiratory failure and bradyarrhythmia (45 b.p.m.). During hospitalization, she was also administered anti-viral treatment, convalescent plasma therapy, and continuous renal replacement therapy. She was maintained on ECMO before she had fully recovered from the condition that necessitated ECMO use and had a negative test for the nucleic acids of SARS-CoV-2 twice. Forty-nine days later, this patient was weaned from ECMO. At the most recent follow-up visit (3\u2009months after weaning from ECMO), she received respiratory and cardiac rehabilitation and did not complain of any discomfort.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>As far as we know, the longest duration of ECMO treatment in this critical case with COVID-19 is supportive of ECMO as the most aggressive form of life support and the last line of defence during the COVID-19 epidemic.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa462","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T06:33:57Z","timestamp":1607927637000},"source":"Crossref","is-referenced-by-count":4,"title":["Recovery from respiratory failure after 49-day extracorporeal membrane oxygenation support in a critically ill patient with COVID-19: case report"],"prefix":"10.1093","volume":"5","author":[{"given":"Fengwei","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Cardiovascular surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, No. 277 Yanta West Road, Xi\u2019an, 710061, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, No. 277 Yanta West Road, Xi\u2019an, 710061, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, No. 277 Yanta West Road, Xi\u2019an, 710061, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-0261","authenticated-orcid":false,"given":"Yang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular surgery, First Affiliated Hospital of Xi\u2019an Jiaotong University, No. 277 Yanta West Road, Xi\u2019an, 710061, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,12]]},"reference":[{"key":"2021062103202634500_ytaa462-B1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA"},{"key":"2021062103202634500_ytaa462-B2","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/jmv.25822","article-title":"Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis","volume":"92","author":"Cao","year":"2020","journal-title":"J Med Virol"},{"key":"2021062103202634500_ytaa462-B3","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.hrtlng.2020.03.012","article-title":"ECMO for ARDS due to COVID-19","volume":"49","author":"\u00d1amendys-Silva","year":"2020","journal-title":"Heart Lung"},{"key":"2021062103202634500_ytaa462-B4","author":"WHO","year":"2020"},{"key":"2021062103202634500_ytaa462-B5","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-020-2840-8","article-title":"Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19\u00a0 patients in China: a retrospective case series [J]","volume":"24","author":"Zeng","year":"2020","journal-title":"Crit Care"},{"key":"2021062103202634500_ytaa462-B6","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1056\/NEJMct1103720","article-title":"Extracorporeal membrane oxygenation for ARDS in adults","volume":"365","author":"Brodie","year":"2011","journal-title":"N Engl J Med"},{"key":"2021062103202634500_ytaa462-B7","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1177\/1054773816677808","article-title":"Extracorporeal membrane oxygenation (ECMO) for lung injury in severe acute respiratory distress syndrome (ARDS): review of the literature","volume":"26","author":"Paolone","year":"2017","journal-title":"Clin Nurs Res"},{"key":"2021062103202634500_ytaa462-B8","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1001\/jama.2019.9302","article-title":"Extracorporeal life support for adults with respiratory failure and related indications: a review","volume":"322","author":"Brodie","year":"2019","journal-title":"JAMA"},{"key":"2021062103202634500_ytaa462-B9","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/MAT.0000000000001173","article-title":"Initial ELSO guidance document: ECMO for COVID-19 patients with severe cardiopulmonary failure","volume":"66","author":"Bartlett","year":"2020","journal-title":"ASAIO J"},{"key":"2021062103202634500_ytaa462-B10","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-2600(20)30328-3","article-title":"Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study","author":"Schmidt","year":"2020","journal-title":"Lancet Respir Med"},{"key":"2021062103202634500_ytaa462-B11","first-page":"1121","article-title":"Preparing for the most critically ill patients \u00a0with COVID-19: the potential role of extracorporeal membrane oxygenation","volume":"8","author":"MacLaren","year":"2020","journal-title":"JAMA"},{"key":"2021062103202634500_ytaa462-B12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1055\/s-0038-1642066","article-title":"Timing of ECMO initiation impacts survival in influenza-associated ARDS","volume":"67","author":"Steimer","year":"2019","journal-title":"Thorac Cardiovasc Surg"},{"key":"2021062103202634500_ytaa462-B13","first-page":"493","article-title":"The implementation of a pulmonary embolism response team in the management of intermediate- or high-risk pulmonary embolism [J]","volume":"7","author":"Xenos","year":"2019","journal-title":"J Vasc Surg"},{"key":"2021062103202634500_ytaa462-B14","first-page":"e48","article-title":"Prone position in management of COVID-19 patients; 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