{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:12:40Z","timestamp":1766268760356,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Studies about the incidence and severity of coronavirus disease 2019 (COVID-19) in children are still significantly lower than those in adults. Moreover, data on the effect of COVID-19 in children with congenital heart disease (CHD) are limited. To the best of our knowledge, this study first reported mortality in a child with CHD who acquired COVID-19.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 16-month-old boy presented to the emergency department due to shortness of breath, fever, cough, and poor oral intake. He tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). He required mechanical ventilation for rapidly progressing respiratory failure. The patient had a large mid-muscular ventricular septal defect (VSD) that was closed percutaneously at the age of 13\u2009months. Moreover, we followed his hospital sequelae from admission to death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This child had multiple risk factors, including malnutrition and persistent pulmonary hypertension (PH) after late closure of the VSD. The pre-existing PH could have been aggravated by the lung condition associated with COVID-19 and the respiratory failure triggered by SARS-CoV-2 infection. The patient presented with ventricular systolic dysfunction, elevated troponin serum levels and newly developed trifascicular block, which were indicative of myocardial injury. The elevated inflammatory markers and multi-organ dysfunction seem to corroborate multisystem inflammatory syndrome in children, which was described recently among paediatric patients with COVID-19.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa478","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T08:59:29Z","timestamp":1607936369000},"source":"Crossref","is-referenced-by-count":2,"title":["Impact of coronavirus disease 2019 in a child who underwent ventricular septal defect device closure: a case report"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2381-7502","authenticated-orcid":false,"given":"Saud A","family":"Bahaidarah","sequence":"first","affiliation":[{"name":"Pediatric Cardiology Division, Department of Pediatrics, King Abdulaziz University, PO Box 80215, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8856-9143","authenticated-orcid":false,"given":"Ahmed M","family":"Dohain","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Division, Department of Pediatrics, King Abdulaziz University, PO Box 80215, Jeddah 21589, Saudi Arabia"},{"name":"Pediatric Cardiology Division, Department of Pediatrics, Cairo University, Kasr Al Ainy Faculty of Medicine, Al-Manial 11956, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-2921","authenticated-orcid":false,"given":"Gaser","family":"Abdelmohsen","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Division, Department of Pediatrics, King Abdulaziz University, PO Box 80215, Jeddah 21589, Saudi Arabia"},{"name":"Pediatric Cardiology Division, Department of Pediatrics, Cairo University, Kasr Al Ainy Faculty of Medicine, Al-Manial 11956, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer A","family":"Alnajjar","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases Division, Department of Pediatrics, King Abdulaziz University, PO Box 80215, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jameel","family":"Al-Ata","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Division, Department of Pediatrics, King Abdulaziz University, PO Box 80215, Jeddah 21589, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,20]]},"reference":[{"key":"2021062103201732500_ytaa478-B1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu","year":"2020","journal-title":"N Engl J 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