{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:16:58Z","timestamp":1760203018046,"version":"3.41.2"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T00:00:00Z","timestamp":1608854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Severe coronavirus-induced disease 2019 (COVID-19) leads to acute respiratory distress syndrome with an increased risk of venous thrombo-embolic events. To a much lesser extent, arterial thrombo-embolic events have also been reported in this setting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>Here, we describe four different cases of COVID-19 infection with ischaemic arterial events, such as a myocardial infarction with high thrombus load, ischaemic stroke on spontaneous thrombosis of the aortic valve, floating thrombus with mesenteric, splenic and renal infarction, and acute limb ischaemia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Cardiovascular risk factors such as hypertension, obesity, and diabetes are comorbidities most frequently found in patients with a severe COVID-19 infection and are associated with a higher death rate. Our goal is to provide an overview of the clinical spectrum of ischaemic arterial events that may either reveal or complicate COVID-19. Several suspected pathophysiological mechanisms could explain the association between cardiovascular events and COVID-19 (role of systemic inflammatory response syndrome, endothelial dysfunction, activation of coagulation cascade leading to a hypercoagulability state, virus-induced secondary antiphospholipid syndrome). We need additional studies of larger size, to estimate the incidence of these arterial events and to assess the efficacy of anticoagulation therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa488","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T12:40:29Z","timestamp":1608900029000},"source":"Crossref","is-referenced-by-count":13,"title":["Clinical spectrum of ischaemic arterial diseases associated with COVID-19: a series of four illustrative cases"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5868-7007","authenticated-orcid":false,"given":"Henri","family":"Guillet","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, Facult\u00e9 de m\u00e9decine, 8 Rue du G\u00e9n\u00e9ral Sarrail, 94000 Cr\u00e9teil, France"},{"name":"D\u00e9partement d\u2019Aval des Urgences, H\u00f4pital Henri Mondor, Assistance Publique H\u00f4pitaux de Paris, 51 Avenue du Mar\u00e9chal de Lattre de Tassigny, 94010 Cr\u00e9teil, France"},{"name":"Service de M\u00e9decine interne, Unit\u00e9 des maladies g\u00e9n\u00e9tiques du globule rouge, H\u00f4pital Henri Mondor, Assistance Publique H\u00f4pitaux de Paris, 51 avenue du Mar\u00e9chal de Lattre de Tassigny, 94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Gallet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Est Cr\u00e9teil, Facult\u00e9 de m\u00e9decine, 8 Rue du G\u00e9n\u00e9ral Sarrail, 94000 Cr\u00e9teil, France"},{"name":"Service de cardiologie, H\u00f4pital Henri Mondor, Assistance Publique H\u00f4pitaux de Paris, 51 Avenue du Mar\u00e9chal de Lattre de Tassigny, 94010 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Pham","sequence":"additional","affiliation":[{"name":"Service de cardiologie, H\u00f4pital Henri Mondor, Assistance Publique H\u00f4pitaux 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