{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:10:49Z","timestamp":1740179449732,"version":"3.37.3"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T00:00:00Z","timestamp":1607817600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Platypnoea\u2013orthodeoxia syndrome (POS) is an uncommon condition characterized by dyspnoea and arterial desaturation in the standing or sitting position that improves in the supine position.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We report two cases of POS caused by an atrial septal defect (ASD) and a patent foramen ovale (PFO). Both cases reported a recent decrease in body weight of more than 10\u2009kg in a short time period. Transoesophageal echocardiography (TOE) with agitated saline bubble study revealed and a large amount of contrast bubble through the ASD (Patient 1) or the PFO (Patient 2) from the right atrium to the left atrium in the sitting position. Both patients were diagnosed by the finding of positional dyspnoea and the results of TOE using agitated saline bubble contrast.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Taken together, their presentations suggest that weight loss in a short time period could be a pathogenic factor for POS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa498","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T10:43:45Z","timestamp":1607856225000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Platypnoea\u2013orthodeoxia syndrome induced by short-term weight loss: a case series"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-8436","authenticated-orcid":false,"given":"Yudai","family":"Tamura","sequence":"first","affiliation":[{"name":"Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, 5-3-1 Chikami Minami-ku, Kumamoto 861-4193, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, 5-3-1 Chikami Minami-ku, Kumamoto 861-4193, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,12]]},"reference":[{"key":"2021010812302899500_ytaa498-B1","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.jcin.2016.07.003","article-title":"Percutaneous intervention to treat platypnea-orthodeoxia syndrome: the Toronto experience","volume":"9","author":"Shah","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"key":"2021010812302899500_ytaa498-B2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.rmed.2017.05.016","article-title":"The multiple dimensions of platypnea-orthodeoxia syndrome: a review","volume":"129","author":"Agrawal","year":"2017","journal-title":"Respir Med"},{"key":"2021010812302899500_ytaa498-B3","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/clc.22301","article-title":"Cardiac platypnea-orthodeoxia syndrome: an often unrecognized malady","volume":"37","author":"Joseph","year":"2014","journal-title":"Clin Cardiol"},{"key":"2021010812302899500_ytaa498-B4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00059-016-4479-4","article-title":"Platypnea-orthodeoxia syndrome: orthostatic dyspnea and possible pathophysiological substrates","volume":"42","author":"De Vecchis","year":"2017","journal-title":"Herz"},{"key":"2021010812302899500_ytaa498-B5","first-page":"2599","article-title":"The platypnea-orthodeoxia syndrome","volume":"18","author":"Akin","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2021010812302899500_ytaa498-B6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nrcardio.2010.224","article-title":"Patent foramen ovale: anatomy, outcomes, and closure","volume":"8","author":"Calvert","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"2021010812302899500_ytaa498-B7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.5935\/0103-507X.20140044","article-title":"Platypnea-orthodeoxia syndrome in patients presenting enlarged aortic root: case report and literature review","volume":"26","author":"Townsend","year":"2014","journal-title":"Rev Bras Ter Intensiva"},{"key":"2021010812302899500_ytaa498-B8","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.athoracsur.2009.01.047","article-title":"Platypnea-orthodeoxia syndrome: a rare complication after right pneumonectomy","volume":"88","author":"Bhattacharya","year":"2009","journal-title":"Ann Thorac Surg"},{"key":"2021010812302899500_ytaa498-B9","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2012-007735","article-title":"Platypnea-orthodeoxia syndrome related to right hemidiaphragmatic elevation and a \u2018stretched\u2019 patent foramen ovale","volume":"2012","author":"Sakagianni","year":"2012","journal-title":"BMJ Case Rep"},{"key":"2021010812302899500_ytaa498-B10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1053\/euhj.1999.1944","article-title":"Atrial right-to-left shunting causing severe hypoxaemia despite normal right-sided pressures. 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