{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:06:30Z","timestamp":1792857990431,"version":"4.5.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministry of Health of the Czech Republic","doi-asserted-by":"publisher","award":["AZV NU20-02-00244"],"award-info":[{"award-number":["AZV NU20-02-00244"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Stereotactic body radiotherapy (SBRT) has emerged recently as a novel therapeutic alternative for patients with ventricular tachycardias (VTs) resistant to convetional treatment. Nevertheless, many aspects related to SBRT are currently unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 66-year-old man with ischaemic heart disease, a history of coronary artery bypass graft surgery and left ventricular dysfunction was referred for recurrent symptomatic episodes of slow VT (108 b.p.m.). The arrhythmia was resistant to antiarrhythmic drug therapy with amiodarone and repeated catheter ablation. The patient was scheduled to SBRT, however, the first session failed to suppress VT recurrences. After 20\u2009months, the patient underwent re-do ablation procedure that revealed a newly developed scar with its core adjacent to the presumed critical part of the VT substrate. Catheter ablation again failed to eliminate VT and the second session of SBRT was scheduled. To improve targeting of the VT substrate for SBRT, we applied our recently developed original method for integration of data from the electroanatomical mapping system with computer tomography images. The second session of SBRT with precise targeting using the novel strategy led within 3 months to the successful elimination of VT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This case report describes a patient in whom the recurrent VT was abolished only by properly targeted SBRT. Above all, the case highlights the importance of precise identification and targeting for SBRT. Our case also documents in vivo, by electroanatomical voltage mapping, the development of SBRT-related myocardial lesion. This represents an important mechanistic proof of the concept of SBRT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa516","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T06:00:11Z","timestamp":1609135211000},"source":"Crossref","is-referenced-by-count":20,"title":["A case report of successful elimination of recurrent ventricular tachycardia by repeated stereotactic radiotherapy: the importance of accurate target volume delineation"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-0071","authenticated-orcid":false,"given":"Petr","family":"Peichl","sequence":"first","affiliation":[{"name":"Department of Cardiology, Institute for Clinical and Experimental Medicine (IKEM), V\u00edde\u0148sk\u00e1 1958\/9, Prague 140 21, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1379-0086","authenticated-orcid":false,"given":"Marek","family":"Sramko","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute for Clinical and Experimental Medicine (IKEM), V\u00edde\u0148sk\u00e1 1958\/9, Prague 140 21, Czech Republic"},{"name":"First Faculty of Medicine, Charles University, Kate\u0159insk\u00e1 1660\/32, Prague 121 08, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1579-1792","authenticated-orcid":false,"given":"Jakub","family":"Cvek","sequence":"additional","affiliation":[{"name":"Department of Oncology, University Hospital Ostrava,\u00a017. listopadu 1790\/5, Ostrava, 708 00, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1632-6182","authenticated-orcid":false,"given":"Josef","family":"Kautzner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute for Clinical and Experimental Medicine (IKEM), V\u00edde\u0148sk\u00e1 1958\/9, Prague 140 21, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,27]]},"reference":[{"key":"2021021009364407700_ytaa516-B1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/europace\/euz132","article-title":"2019 HRS\/EHRA\/APHRS\/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias","volume":"21","author":"Cronin","year":"2019","journal-title":"Europace"},{"key":"2021021009364407700_ytaa516-B2","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1093\/europace\/euz133","article-title":"Stereotactic radiosurgery for ablation of ventricular tachycardia","volume":"21","author":"Neuwirth","year":"2019","journal-title":"Europace"},{"key":"2021021009364407700_ytaa516-B3","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1056\/NEJMoa1613773","article-title":"Noninvasive cardiac radiation for ablation of ventricular tachycardia","volume":"377","author":"Cuculich","year":"2017","journal-title":"N Engl J Med"},{"key":"2021021009364407700_ytaa516-B4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/CIRCULATIONAHA.118.038261","article-title":"Phase I\/II trial of electrophysiology-guided noninvasive cardiac radioablation for ventricular tachycardia","volume":"139","author":"Robinson","year":"2019","journal-title":"Circulation"},{"key":"2021021009364407700_ytaa516-B5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.hrcr.2018.10.007","article-title":"Stereotactic radiosurgery as a treatment for recurrent ventricular tachycardia associated with cardiac fibroma","volume":"5","author":"Haskova","year":"2019","journal-title":"HeartRhythm Case Rep"},{"issue":"Supplement_1","key":"2021021009364407700_ytaa516-B6","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehz746.0067","article-title":"Stereotactic radioablation of ventricular tachycardia guided by direct integration of 3D electroanatomic mapping: development and validation of a new method","volume":"40","author":"Sramko","year":"2019","journal-title":"Eur Heart J"},{"key":"2021021009364407700_ytaa516-B7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/CIRCEP.110.959957","article-title":"Endocardial unipolar voltage mapping to detect epicardial ventricular tachycardia substrate in patients with nonischemic left ventricular cardiomyopathy","volume":"4","author":"Hutchinson","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2021021009364407700_ytaa516-B8","doi-asserted-by":"crossref","first-page":"e006108","DOI":"10.1161\/CIRCEP.117.006108","article-title":"How accurate is inverse electrocardiographic mapping? 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