{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T22:10:40Z","timestamp":1774908640926,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Diffuse myocardial calcification following severe sepsis is a rare complication whose long-term effects are not well-understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 51-year-old man presented with a 6-month history of worsening dyspnoea on a background of sepsis 9\u2009years prior. His initial echocardiogram showed moderate systolic dysfunction and a mildly dilated left ventricle. Cardiac computed tomography showed signs of mild coronary artery disease without significant stenosis, but the diffuse extensive left ventricular (LV) mid-myocardial calcification was visible. Cardiac magnetic resonance imaging showed diffuse extensive LV mid-myocardial late gadolinium enhancement in keeping with the calcification. He was diagnosed with non-ischaemic cardiomyopathy. He was commenced on appropriate anti-failure medical therapy, maintains New York Heart Association functional class II functional status, and has received a prophylactic implantable cardioverter-defibrillator.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Diffuse myocardial calcification might be associated with long-term development of non-ischaemic cardiomyopathy. The benefit of monitoring such patients for long-term effects is not routine, but should be considered.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytaa564","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T20:31:49Z","timestamp":1613853109000},"source":"Crossref","is-referenced-by-count":8,"title":["A case report: extensive myocardial calcification and non-ischaemic cardiomyopathy related to past sepsis"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-8472","authenticated-orcid":false,"given":"Anthony","family":"Lim","sequence":"first","affiliation":[{"name":"The University of Melbourne, Victoria 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8631-8321","authenticated-orcid":false,"given":"Kim Kuy","family":"Be","sequence":"additional","affiliation":[{"name":"Sunshine Hospital, 176 Furlong Road, St Albans, VIC 3021, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiew","family":"Wong","sequence":"additional","affiliation":[{"name":"The University of Melbourne, Victoria 3010, Australia"},{"name":"Northern Hospital Epping, 185 Cooper Street, Epping, VIC 3076, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"2021021803481836300_ytaa564-B1","author":"World Health Organization","year":"2018"},{"key":"2021021803481836300_ytaa564-B2","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1161\/CIRCULATIONAHA.115.019178","article-title":"A curious case of acute myocardial calcifications","volume":"133","author":"Torfs","year":"2016","journal-title":"Circulation"},{"key":"2021021803481836300_ytaa564-B3","first-page":"yty126","article-title":"Fleckenstein\u2019s hypothesis revisited: excessive myocardial calcification after prolonged high dose catecholamine treatment: a case report","volume":"2","author":"Dederer","year":"2018","journal-title":"Eur Heart J Case Rep"},{"key":"2021021803481836300_ytaa564-B4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrcardio.2014.159","article-title":"Cardiac MRI: a central prognostic tool in myocardial fibrosis","volume":"12","author":"Ambale-Venkatesh","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"2021021803481836300_ytaa564-B5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jflm.2019.05.004","article-title":"Septic myocardial calcification: a case report","volume":"65","author":"Maiese","year":"2019","journal-title":"J Forensic Leg Med"},{"key":"2021021803481836300_ytaa564-B6","first-page":"e16","article-title":"Sepsis-related myocardial calcification","volume":"4","author":"Kruijsdijk","year":"2011","journal-title":"Circ Heart Fail"},{"key":"2021021803481836300_ytaa564-B7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00428-003-0816-0","article-title":"Sepsis-related microvascular myocardial damage with giant cell inflammation and calcification","volume":"443","author":"Rossi","year":"2003","journal-title":"Virchows Archiv"},{"key":"2021021803481836300_ytaa564-B8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1159\/000064670","article-title":"Myocardial calcification following septic shock","volume":"98","author":"Schellhammer","year":"2002","journal-title":"Cardiology"},{"key":"2021021803481836300_ytaa564-B9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1046\/j.1365-2796.2000.00588.x","article-title":"Left ventricular calcification following resuscitation","volume":"248","author":"Lapatto-Reiniluoto","year":"2000","journal-title":"J Intern Med"},{"key":"2021021803481836300_ytaa564-B10","first-page":"1","article-title":"Calcification of the myocardium; a pathologic study of 13 cases","volume":"48","author":"Gore","year":"1949","journal-title":"Arch Pathol (Chic)"},{"key":"2021021803481836300_ytaa564-B11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jacc.2016.03.605","article-title":"Cardiac sarcoidosis","volume":"68","author":"Birnie","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2021021803481836300_ytaa564-B12","author":"Mavrogeni","year":"2020"},{"key":"2021021803481836300_ytaa564-B13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41572-019-0084-1","article-title":"Dilated cardiomyopathy","volume":"5","author":"Schultheiss","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"2021021803481836300_ytaa564-B14","first-page":"1","article-title":"Role of Q-waves ECG in myocardial scar assessment in patients with prior myocardial infarction","volume":"5","author":"Lucia","year":"2019","journal-title":"Med Clin Rev"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/2\/ytaa564\/36302848\/ytaa564.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/2\/ytaa564\/36302848\/ytaa564.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T20:32:00Z","timestamp":1613853120000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytaa564\/6141549"}},"subtitle":[],"editor":[{"given":"Elena","family":"Cavaretta","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Danny van de","family":"Sande","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Alberto","family":"Bouzas-Mosquera","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Stefan","family":"Simovic","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Ross","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytaa564","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2,1]]},"published":{"date-parts":[[2021,2,1]]},"article-number":"ytaa564"}}