{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:21:14Z","timestamp":1792794074460,"version":"4.5.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Cardiology of the Leiden University Medical Center","id":[{"id":"https:\/\/ror.org\/05xvt9f17","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005039","name":"Leiden University Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\u2003<\/jats:title>\n                    <jats:p>Patients with congenitally corrected transposition of the great arteries (ccTGA) are prone to the development of advanced atrio-ventricular block requiring chronic ventricular pacing. The morphological right ventricle (RV) often develops systolic dysfunction as it is unable to withstand the chronic pressure overload it is exposed to when supporting the systemic circulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary\u2003<\/jats:title>\n                    <jats:p>A 56-year-old woman with dextrocardia and complex ccTGA with a history of dual-chamber implantable cardioverter-defibrillator (DDD-ICD, high degree atrio-ventricular-block and syncopal ventricular tachycardia), presented with progressive heart failure and symptomatic atrial arrhythmias. She underwent a successful ablation and concomitant invasive haemodynamic evaluation of potential alternative\/biventricular pacing modalities. During biventricular pacing, the QRS narrowed and the systemic RV intraventricular pressure (Dp\/Dt) increased with 30%. She underwent a successful transvenous upgrade to cardiac resynchronization therapy (CRT). The electrocardiogram post-implantation showed biventricular capture and patient showed subjective and objective clinical improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion\u2003<\/jats:title>\n                    <jats:p>Systemic RV dysfunction in ccTGA can be aggravated by chronic pacing-induced dyssynchrony, contributing to progression of heart failure in this patient group. Transvenous CRT is feasible in ccTGA anatomy and may be pursued in order to improve or preserve the functional status of pacing-dependent ccTGA patients. Invasive haemodynamic contractility evaluation can help assess the potential benefit of CRT in patients with complex anatomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytab068","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T04:55:05Z","timestamp":1618203305000},"source":"Crossref","is-referenced-by-count":6,"title":["Failing systemic right ventricle in a patient with dextrocardia and complex congenitally corrected transposition of the great arteries: a case report of successful transvenous cardiac resynchronization therapy"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4893-6575","authenticated-orcid":false,"given":"Marieke","family":"Nederend","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden, the Netherlands"},{"name":"CAHAL, Center for Congenital Heart Disease Amsterdam Leiden, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieselot","family":"van Erven","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Zeppenfeld","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert W","family":"Vliegen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden, the Netherlands"},{"name":"CAHAL, Center for Congenital Heart Disease Amsterdam Leiden, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9312-2338","authenticated-orcid":false,"given":"Anastasia D","family":"Egorova","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden Heart-Lung Center, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden, the Netherlands"},{"name":"CAHAL, Center for Congenital Heart Disease Amsterdam Leiden, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"2022081605465440400_ytab068-B1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s002469900502","article-title":"Congenital heart disease among 815,569 children born between 1980 and 1990 and their 15-year survival: a prospective bohemia survival study","volume":"20","author":"Sam\u00e1nek","year":"1999","journal-title":"Pediatr Cardiol"},{"key":"2022081605465440400_ytab068-B2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1161\/CIRCULATIONAHA.116.022106","article-title":"Management of systemic right ventricular failure in patients with congenitally corrected transposition of the great arteries","volume":"134","author":"Filippov","year":"2016","journal-title":"Circulation"},{"key":"2022081605465440400_ytab068-B3","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.jtcvs.2013.02.030","article-title":"The natural and unnatural history of the systemic right ventricle in adult survivors","volume":"145","author":"Dobson","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022081605465440400_ytab068-B4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00246-001-0037-8","article-title":"Outcome of 121 patients with congenitally corrected transposition of the great arteries","volume":"23","author":"Rutledge","year":"2002","journal-title":"Pediatr Cardiol"},{"key":"2022081605465440400_ytab068-B5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/europace\/eun319","article-title":"Effects of cardiac resynchronization therapy on echocardiographic indices, functional capacity, and clinical outcomes of patients with a systemic right ventricle","volume":"11","author":"Jauvert","year":"2009","journal-title":"Europace"},{"key":"2022081605465440400_ytab068-B6","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007759","article-title":"Cardiac conduction system in congenitally corrected transposition of the great arteries and its clinical relevance","volume":"6","author":"Baruteau","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2022081605465440400_ytab068-B7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jtcvs.2015.08.064","article-title":"Impact of pacing on systemic ventricular function in L-transposition of the great arteries","volume":"151","author":"Hofferberth","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2022081605465440400_ytab068-B8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00399-016-0433-7","article-title":"Cardiac resynchronization therapy in congenital heart disease","volume":"27","author":"Janou\u0161ek","year":"2016","journal-title":"Herzschr Elektrophys"},{"key":"2022081605465440400_ytab068-B9","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.jacep.2017.01.015","article-title":"16 Years of cardiac resynchronization pacing among congenital heart disease patients: direct contractility (dP\/dt-max) screening when the guidelines do not apply","volume":"3","author":"Karpawich","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"key":"2022081605465440400_ytab068-B10","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1161\/CIRCULATIONAHA.113.001383","article-title":"Cardiac resynchronization therapy for pediatric patients with heart failure and congenital heart disease: a reappraisal of results","volume":"129","author":"Motonaga","year":"2014","journal-title":"Circulation"},{"key":"2022081605465440400_ytab068-B11","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1161\/01.CIR.102.25.3053","article-title":"Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block","volume":"102","author":"Nelson","year":"2000","journal-title":"Circulation"},{"key":"2022081605465440400_ytab068-B12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s12471-019-01314-y","article-title":"Ventricular assist device implantation in patients with a failing systemic right ventricle: a call to expand current practice","volume":"27","author":"Zandstra","year":"2019","journal-title":"Neth Heart J"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/4\/ytab068\/45434225\/ytab068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/4\/ytab068\/45434225\/ytab068.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T01:47:16Z","timestamp":1660614436000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytab068\/6220424"}},"subtitle":[],"editor":[{"given":"Inga","family":"Voges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Ina","family":"Michel-Behnke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Mohammed","family":"Al-Hijji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Kajaluxy","family":"Ananthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Aiste Monika","family":"Jakstaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,5]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytab068","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,4,1]]},"published":{"date-parts":[[2021,4,1]]},"article-number":"ytab068"}}