{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:55:37Z","timestamp":1781931337746,"version":"3.54.5"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hyperthyroidism is commonly associated with adverse cardiovascular effects, including tachydysrhythmia, heart failure, and hypertension, although the association between hyperthyroidism and myopericarditis is restricted to a small number of case reports.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 45-year-old Caucasian male with no past medical history was admitted with chest pain. The electrocardiogram demonstrated diffuse ST-segment elevation, the troponin T rose, and he was diagnosed with myopericarditis. He was noted to have markedly deranged thyroid function tests and a diagnosis of hyperthyroidism secondary to Graves\u2019 disease was made. He was treated with Bisoprolol, Carbimazole, Prednisolone, Ibuprofen, and Colchicine, his symptoms resolved rapidly and he was discharged. Five weeks later he re-presented with similar symptoms and recurrent pericarditis was diagnosed. His symptoms settled with a repeat course of steroids.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>We hypothesize that there may be an underappreciated link between hyperthyroidism and myopericarditis. Potential pathophysiological mechanisms include viral infection, autoimmunity, or changes in myocardial fat metabolism. Suggested management consists of a combination of current guidelines for the treatment of hyperthyroidism and pericardial disease, with attention to certain disease\u2013drug interactions. Further research is required to evaluate the true incidence of hyperthyroidism-associated myopericarditis, elucidate its pathophysiology and instruct management.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytab192","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T06:19:44Z","timestamp":1626934784000},"source":"Crossref","is-referenced-by-count":6,"title":["Myopericarditis and thyroiditis: a case report"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8229-8060","authenticated-orcid":false,"given":"Ross J","family":"Thomson","sequence":"first","affiliation":[{"name":"Department of Cardiology, Royal Free Hospital, Royal Free London NHS Foundation Trust, Pond Street, London NW3 2QG, UK"},{"name":"William Harvey Research Institute, Queen Mary University of London, 1 St Martin's le Grand, London EC1A 4AS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-5247","authenticated-orcid":false,"given":"Nora","family":"Rossberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Free Hospital, Royal Free London NHS Foundation Trust, Pond Street, London NW3 2QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Davar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Free Hospital, Royal Free London NHS Foundation Trust, Pond Street, London NW3 2QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Whelan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Free Hospital, Royal Free London NHS Foundation Trust, Pond Street, London NW3 2QG, UK"},{"name":"National Amyloidosis Centre, Royal Free Hospital, Royal Free London NHS Foundation Trust, Pond Street, London NW3 2QG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"key":"2021072206193265500_ytab192-B1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijcard.2015.06.130","article-title":"Thyrotoxic pericarditis: an underappreciated phenomenon","volume":"198","author":"Gupta","year":"2015","journal-title":"Int J Cardiol"},{"key":"2021072206193265500_ytab192-B2","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.1016\/j.ijcard.2013.12.042","article-title":"Acute pericarditis: unique comorbidity of thyrotoxic crisis with Graves\u2019 disease","volume":"171","author":"Inami","year":"2014","journal-title":"Int J Cardiol"},{"key":"2021072206193265500_ytab192-B3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jccase.2016.06.005","article-title":"Acute myocarditis in bodybuilder from coxsackievirus and thyrotoxicosis","volume":"14","author":"Kwak","year":"2016","journal-title":"J Cardiol Cases"},{"key":"2021072206193265500_ytab192-B4","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/ccr3.2273","article-title":"Acute autoimmune myocarditis as a manifestation of Graves\u2019 disease: a case report and review of the literature","volume":"7","author":"Lancaster","year":"2019","journal-title":"Clin Case Rep"},{"key":"2021072206193265500_ytab192-B5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ajem.2005.10.020","article-title":"Acute pericarditis: a rare complication of Graves\u2019 thyrotoxicosis?","volume":"24","author":"Tsai","year":"2006","journal-title":"Am J Emerg Med"},{"key":"2021072206193265500_ytab192-B6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4070\/kcj.2012.42.6.419","article-title":"Acute recurrent pericarditis accompanied by Graves\u2019 disease","volume":"42","author":"Koo","year":"2012","journal-title":"Korean Circ J"},{"key":"2021072206193265500_ytab192-B7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ijcard.2012.04.089","article-title":"Hyperthyroidism induced autoimmune myocarditis. 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