{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T17:01:33Z","timestamp":1761238893326,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":96,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The clinical course of penetrating atherosclerotic ulcers is variable and can be complicated with intramural haematomas, dissection, pseudoaneurysms, or aortic rupture. Because it can lead to life-threatening conditions, it needs to be managed carefully.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 68-year-old woman, who was treated for acute myeloid leukaemia (subtype: M0-FAB) approximately 1\u2009year before presentation, visited the hospital with complaints of a headache and lumbar pain. After hospitalization, investigations revealed miliary tuberculosis. On the same day, she developed a Stanford type A acute aortic dissection (AAD) with cardiac tamponade; during the course of the previous leukaemia treatment, a small ulcerative lesion at the distal aortic arch grew into a small saccular aortic aneurysm (SAA) that expanded rapidly and finally developed into a Stanford type A AAD. However, the relationship between the SAA and aortic dissection could not be confirmed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>The chronological changes in the atherosclerotic lesion at the distal aortic arch could be clearly observed because computed tomography scans were repeatedly obtained until just before the onset of AAD. The rapid progression of atherosclerotic lesions in the unique context of leukaemia treatment and miliary tuberculosis was considered to be a pathological characteristic, and the mechanism underlying this process was investigated. Clinicians should be aware of the aortic complications that may progress under special circumstances, such as anthracycline use or immunodeficiency. Careful observation is mandatory for patients with aortic disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytab196","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T08:02:16Z","timestamp":1626076936000},"source":"Crossref","is-referenced-by-count":3,"title":["A penetrating atherosclerotic ulcer rapidly growing into a saccular aortic aneurysm during treatment of leukaemia: a case report"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-7018","authenticated-orcid":false,"given":"Shinsuke","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Department of Cardiology, Kyorin University School of Medicine , 6-20-2 Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-9657","authenticated-orcid":false,"given":"Nobuyuki","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Hematology, Kyorin University School of Medicine , 6-20-2 Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Soejima","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kyorin University School of Medicine , 6-20-2 Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4976-4055","authenticated-orcid":false,"given":"Hideaki","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kyorin University School of Medicine , 6-20-2 Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"2022081607170631000_ytab196-B1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0890-5096(06)60697-3","article-title":"Penetrating atherosclerotic ulcers of the thoracic aorta: natural history and clinicopathologic correlations","volume":"1","author":"Stanson","year":"1986","journal-title":"Ann Vasc Surg"},{"key":"2022081607170631000_ytab196-B2","doi-asserted-by":"crossref","first-page":"456","DOI":"10.21037\/acs.2019.07.05","article-title":"Intramural hematoma and penetrating ulcer in the descending aorta: differences and similarities","volume":"8","author":"Evangelista","year":"2019","journal-title":"Ann Cardiothorac Surg"},{"key":"2022081607170631000_ytab196-B3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jvs.2012.07.002","article-title":"A modern experience with saccular aortic aneurysms","volume":"57","author":"Shang","year":"2013","journal-title":"J Vasc Surg"},{"key":"2022081607170631000_ytab196-B4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/1471-2334-11-324","article-title":"Clinical characteristics and outcomes of Mycobacterium tuberculosis disease in adult patients with hematological malignancies","volume":"11","author":"Chen","year":"2011","journal-title":"BMC Infect Dis"},{"key":"2022081607170631000_ytab196-B5","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1378\/chest.115.2.522","article-title":"Tuberculous mycotic aneurysm of the aorta: review of published medical and surgical experience","volume":"115","author":"Long","year":"1999","journal-title":"Chest"},{"key":"2022081607170631000_ytab196-B6","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1001\/archsurg.1991.01410310083012","article-title":"Management of infected aortoiliac aneurysms","volume":"126","author":"Reddy","year":"1991","journal-title":"Arch Surg"},{"key":"2022081607170631000_ytab196-B7","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.21873\/invivo.11420","article-title":"The assessment of left ventricle function and subclinical atherosclerosis in patients with acute myeloid leukemia","volume":"32","author":"Militaru","year":"2018","journal-title":"In Vivo"},{"key":"2022081607170631000_ytab196-B8","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jcmg.2012.11.017","article-title":"Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease","volume":"6","author":"Drafts","year":"2013","journal-title":"JACC Cardiovasc Imaging"},{"key":"2022081607170631000_ytab196-B9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1200\/JCO.2009.23.8527","article-title":"Aortic stiffness increases upon receipt of anthracycline chemotherapy","volume":"28","author":"Chaosuwannakit","year":"2010","journal-title":"J Clin Oncol"},{"key":"2022081607170631000_ytab196-B10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11748-019-01066-x","article-title":"Etiology of aortic dissection","volume":"67","author":"Akutsu","year":"2019","journal-title":"Gen Thorac Cardiovasc Surg"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/7\/ytab196\/45434502\/ytab196.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/7\/ytab196\/45434502\/ytab196.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T07:17:26Z","timestamp":1660634246000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytab196\/6318808"}},"subtitle":[],"editor":[{"given":"Konstantinos","family":"Stathogiannis","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Rami Riziq Yousef","family":"Abumuaileq","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Domenico","family":"Filomena","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Carlos Minguito","family":"Carazo","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Ross","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytab196","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2021,7,1]]},"published":{"date-parts":[[2021,7,1]]},"article-number":"ytab196"}}