{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:43Z","timestamp":1753876243886,"version":"3.41.2"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cardiac involvement in Sneddon syndrome (SS) is rare, the physiopathology is still unclear. We report a first case of SS without antiphospholipid antibodies who had coexisting ischaemia with no obstructive coronary arteries and aortic valve diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 34-year-old woman with SS without antiphospholipid antibodies, was admitted for aphasia, and paresthaesia with confirmed right opercular ischaemic lesions at brain magnetic resonance imaging. Transthoracic echocardiographic examination showed akinesis of apical segments, moderate aortic valve stenosis, and moderate aortic insufficiency. Coronary angiogram was normal. Cardiac magnetic resonance showed transmural necrosis in the territory of the left anterior descending artery. Seven years later, our patient had no change or progression of myocardial ischaemic lesions or valvular disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We will discuss different hypothesis, diagnosis, treatment, and evolution of cardiac involvement in SS. Close follow-up should be regularly performed for early diagnosis, hence the importance of multimodality imaging, to guide treatment and prevent further complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytab211","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T07:19:14Z","timestamp":1624432754000},"source":"Crossref","is-referenced-by-count":0,"title":["Concomitant myocardial injury and valvular disease in Sneddon syndrome: a case report"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2484-9733","authenticated-orcid":false,"given":"Soukaina","family":"Scadi","sequence":"first","affiliation":[{"name":"Cardiology department, CHRU Brabois, 1 rue du Morvan, Vandoeuvre les Nancy 54500, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Huttin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Selton Suty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"key":"2021070817005115400_ytab211-B1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1001\/archderm.1993.01680250049006","article-title":"Sneddon\u2019s syndrome: a long-term follow-up of 21 patients","volume":"129","author":"Zelger","year":"1993","journal-title":"Arch Dermatol"},{"key":"2021070817005115400_ytab211-B2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1365-2133.1965.tb14628.x","article-title":"Cerebro-vascular lesions and livedo reticularis","volume":"77","author":"Sneddon","year":"1965","journal-title":"Br J Dermatol"},{"key":"2021070817005115400_ytab211-B3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00005792-199907000-00001","article-title":"Sneddon syndrome with or without antiphospholipid antibodies. A comparative study in 46 patients","volume":"78","author":"Frances","year":"1999","journal-title":"Medicine"},{"key":"2021070817005115400_ytab211-B4","first-page":"345","article-title":"Sneddon\u2019s syndrome as a disorder of small arteries with endothelial cells proliferation: ultrastructural and neuroimaging study","volume":"43","author":"Lewandowska","year":"2005","journal-title":"Folia Neuropathol"},{"key":"2021070817005115400_ytab211-B5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.hoc.2007.10.011","article-title":"Cutaneous manifestations of antiphospholipid antibody syndrome","volume":"22","author":"Weinstein","year":"2008","journal-title":"Hematol Oncol Clin North Am"},{"key":"2021070817005115400_ytab211-B6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ijcard.2015.04.165","article-title":"Cardiac manifestations of Sneddon's syndrome","volume":"190","author":"Dominguez","year":"2015","journal-title":"Int J Cardiol"},{"key":"2021070817005115400_ytab211-B7","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1053\/j.jvca.2005.07.011","article-title":"Mitral valve replacement in a patient with Sneddon syndrome","volume":"19","author":"K\u00f6ner","year":"2005","journal-title":"J Cardiothor Vasc Anesth"},{"key":"2021070817005115400_ytab211-B8","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00059-013-3834-y","article-title":"STEMI of the anterior wall associated with Sneddon's syndrome","volume":"39","author":"Scheuermann","year":"2014","journal-title":"Herz"},{"key":"2021070817005115400_ytab211-B9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/ehjci\/jez312","article-title":"Echocardiographic features in antiphospholipid-negative Sneddon\u2019s syndrome and potential association with severity of neurological symptoms or recurrence of strokes: a longitudinal cohort study","volume":"22","author":"Assan","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2021070817005115400_ytab211-B10","first-page":"001","article-title":"Sneddon\u2019s syndrome: a case report and revision of literature","volume":"76","author":"Leal","year":"2001","journal-title":"An Bras Dermatol"},{"key":"2021070817005115400_ytab211-B11","doi-asserted-by":"crossref","first-page":"iv8","DOI":"10.1093\/rheumatology\/kel308","article-title":"Heart involvement in systemic lupus erythematosus, anti-phospholipid syndrome and neonatal lupus","volume":"45","author":"Tincani","year":"2006","journal-title":"Rheumatology"},{"key":"2021070817005115400_ytab211-B12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.autrev.2014.11.003","article-title":"Antiphospholipid syndrome and the heart: a case series and literature review","volume":"14","author":"Denas","year":"2015","journal-title":"Autoimmun Rev"},{"key":"2021070817005115400_ytab211-B13","first-page":"357","article-title":"Sneddon's syndrome: cardiac pathology and antiphospholipid antibodies","volume":"9","author":"Kalashnikova","year":"1991","journal-title":"Clin Exp Rheumatol"},{"key":"2021070817005115400_ytab211-B14","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1001\/archneur.65.6.834","article-title":"The Sneddon syndrome","volume":"65","author":"Aladdin","year":"2008","journal-title":"Arch Neurol"},{"key":"2021070817005115400_ytab211-B15","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1136\/hrt.2006.092999","article-title":"Sneddon's syndrome: cardiac involvement detected by magnetic resonance imaging","volume":"92","author":"Nassenstein","year":"2006","journal-title":"Heart"},{"key":"2021070817005115400_ytab211-B16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s13023-014-0215-4","article-title":"Sneddon\u2019s syndrome: a comprehensive review of the literature","volume":"9","author":"Wu","year":"2014","journal-title":"Orphanet J Rare Dis"}],"container-title":["European Heart Journal - 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