{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:55:50Z","timestamp":1762005350281,"version":"3.41.2"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Coronavirus disease (COVID-19) is a systemic illness characterized by raging impact of cytokine storm on multiple organs. This may trigger malignant ventricular arrhythmias and unmask a clinically silent cardiomyopathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 57-year-old gentleman, known case of hyperthyroidism and diabetes, was referred to our emergency department with history of two ventricular tachycardia (VT) episodes requiring direct current cardioversion in last 3 h followed by another episode in our emergency department that was cardioverted. There was no past history of cardiac illness. His 12-lead electrocardiogram (during sinus rhythm) along with screening echocardiography suggested Arrhythmogenic right ventricular cardiomyopathy (ARVC). He was coincidentally found to be COVID-19 positive by reverse transcription-polymerase chain reaction (RT-PCR) as part of our routine screening. However, he had no fever or respiratory complaints. We noted raised systemic inflammatory markers and cardiac troponin T which progressively increased over the next 4\u2009weeks paralleled by an increase in ventricular premature contraction burden and thereafter started decreasing and returned to baseline by 6th week when the patient became COVID-19 negative by RT-PCR. Subsequently, a single-chamber automated implantable cardioverter-defibrillator implantation was done following which there was a transient increase in these biomarkers that subsided spontaneously. The patient is asymptomatic during 6\u2009weeks of follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>COVID-19-associated cytokine surge triggering VT storm and unmasking a clinically silent ARVC has not yet been reported. The case highlights a life-threatening presentation of COVID-19 and indicates a probable link between inflammation and arrhythmogenicity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytab220","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T09:43:41Z","timestamp":1627638221000},"source":"Crossref","is-referenced-by-count":8,"title":["COVID-19 induced ventricular tachycardia storm unmasking a clinically silent cardiomyopathy: a case report"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6197-8000","authenticated-orcid":false,"given":"Saibal","family":"Mukhopadhyay","sequence":"first","affiliation":[{"name":"Department of Cardiology, GB Pant Institute of Post Graduate Education and Research, JLN Road, New Delhi 110002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0842-8354","authenticated-orcid":false,"given":"Abhimanyu","family":"Uppal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, GB Pant Institute of Post Graduate Education and Research, JLN Road, New Delhi 110002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-1509","authenticated-orcid":false,"given":"Jamal","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Department of Cardiology, GB Pant Institute of Post Graduate Education and Research, JLN Road, New Delhi 110002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8195-6941","authenticated-orcid":false,"given":"Ghazi","family":"Muheeb","sequence":"additional","affiliation":[{"name":"Department of Cardiology, GB Pant Institute of Post Graduate Education and Research, JLN Road, New Delhi 110002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupesh","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, GB Pant Institute of Post Graduate Education and Research, JLN Road, New Delhi 110002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"2021073009433760400_ytab220-B1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.hrthm.2020.05.001","article-title":"Recognizing COVID-19-related myocarditis: the possible pathophysiology and proposed guideline for diagnosis and management","volume":"17","author":"Siripanthong","year":"2020","journal-title":"Heart Rhythm"},{"key":"2021073009433760400_ytab220-B2","doi-asserted-by":"crossref","first-page":"e008920","DOI":"10.1161\/CIRCEP.120.008920","article-title":"Malignant arrhythmias in patients with COVID-19: incidence, mechanisms, and outcomes","volume":"13","author":"Turagam","year":"2020","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2021073009433760400_ytab220-B3","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.hrthm.2020.06.016","article-title":"COVID-19 and cardiac arrhythmias","volume":"17","author":"Bhatla","year":"2020","journal-title":"Heart Rhythm"},{"key":"2021073009433760400_ytab220-B4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/CIRCULATIONAHA.120.047293","article-title":"COVID-19, arrhythmic risk, and inflammation: mind the gap!","volume":"142","author":"Lazzerini","year":"2020","journal-title":"Circulation"},{"key":"2021073009433760400_ytab220-B5","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.jacc.2018.05.065","article-title":"The present and future clinical diagnosis, imaging, and genetics of arrhythmogenic right ventricular cardiomyopathy\/dysplasia: JACC state-of-the-art review","volume":"72","author":"Gandjbakhch","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2021073009433760400_ytab220-B6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4330\/wjc.v9.i6.521","article-title":"Management of ventricular tachycardia storm in patients with structural heart disease","volume":"9","author":"Muser","year":"2017","journal-title":"World J Cardiol"},{"author":"Arrhythmogenic right ventricular cardiomyopathy: current diagnostic criteria - American College of Cardiology","key":"2021073009433760400_ytab220-B7"},{"key":"2021073009433760400_ytab220-B8","first-page":"1601","article-title":"2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the task force for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death of the European Society of Cardiology (ESC)","volume":"17","author":"Priori","year":"2015","journal-title":"Europace"},{"key":"2021073009433760400_ytab220-B9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/PHM.0000000000001471","article-title":"Interpreting the COVID-19 test results: a guide for physiatrists","volume":"99","author":"Chang","year":"2020","journal-title":"Am J Phys Med Rehabil"},{"key":"2021073009433760400_ytab220-B10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.amjcard.2020.08.033","article-title":"Ventricular fibrillation storm in coronavirus 2019","volume":"135","author":"Elsaid","year":"2020","journal-title":"Am J Cardiol"},{"key":"2021073009433760400_ytab220-B11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ehjcr\/ytaa217","article-title":"Ventricular tachycardia storm management in a COVID-19 patient: a case report","volume":"4","author":"Mitacchione","year":"2020","journal-title":"Eur Hear J Case Rep"},{"key":"2021073009433760400_ytab220-B12","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.jacc.2009.02.007","article-title":"Cardiovascular magnetic resonance in myocarditis: a JACC white paper","volume":"53","author":"Friedrich","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2021073009433760400_ytab220-B13","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCEP.111.964890","article-title":"Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy","volume":"4","author":"Asimaki","year":"2011","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2021073009433760400_ytab220-B14","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0735-1097(01)01654-0","article-title":"Arrhythmogenic right ventricular cardiomyopathy","volume":"38","author":"Gemayel","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"2021073009433760400_ytab220-B15","first-page":"1","article-title":"Biomarkers of myocardial injury and inflammation after permanent pacemaker implantation: the lead fixation type effect","volume":"10","author":"Varvarousis","year":"2018","journal-title":"J Atr Fibrillation"},{"key":"2021073009433760400_ytab220-B16","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.3389\/fphys.2018.01866","article-title":"Cardiolipotoxicity, inflammation, and arrhythmias: role for interleukin-6 molecular mechanisms","volume":"9","author":"Al\u00ed","year":"2019","journal-title":"Front Physiol"},{"key":"2021073009433760400_ytab220-B17","doi-asserted-by":"crossref","first-page":"e010595","DOI":"10.1161\/JAHA.118.010595","article-title":"Emerging arrhythmic risk of autoimmune and inflammatory cardiac channelopathies","volume":"7","author":"Lazzerini","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2021073009433760400_ytab220-B18","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1161\/01.CIR.0000017493.03108.1C","article-title":"Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death","volume":"105","author":"Albert","year":"2002","journal-title":"Circulation"},{"key":"2021073009433760400_ytab220-B19","doi-asserted-by":"crossref","first-page":"e8261","DOI":"10.1161\/JAHA.117.008261","article-title":"Circulating circles predict postoperative atrial fibrillation","volume":"7","author":"Reckman","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2021073009433760400_ytab220-B20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000486957","article-title":"2018 European Thyroid Association (ETA) guidelines for the management of amiodarone-associated thyroid dysfunction","volume":"7","author":"Bartalena","year":"2018","journal-title":"Eur Thyroid J"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/7\/ytab220\/39458480\/ytab220.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/7\/ytab220\/39458480\/ytab220.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T09:44:03Z","timestamp":1627638243000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytab220\/6330927"}},"subtitle":[],"editor":[{"given":"David","family":"Niederseer","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"S\u00f8ren Z\u00f6ga","family":"Diederichsen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Christoph Clemens","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Alexander","family":"Tindale","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Ayse","family":"Djahit","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytab220","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2021,7,1]]},"published":{"date-parts":[[2021,7,1]]},"article-number":"ytab220"}}