{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:15:20Z","timestamp":1760080520663,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Transcatheter mitral valve repair (TMVR) in patients with severe acute mitral regurgitation (MR) and high surgical risk has been described. Moreover, the use of cerebral protection device (CPD) during TMVR in patients without evidence of intracardiac thrombus has been investigated. To the best of our knowledge, TMVR as a rescue therapy in a patient with acute ischaemic MR, cardiogenic shock, and left atrial appendage (LAA) thrombus with concurrent use of CPD has not been reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 59-year-old female with subacute lateral myocardial infarction caused by subacute stent thrombosis after stent implantation in the left circumflex artery 3 weeks previously presented with acute heart failure due to acute severe MR at a peripheral hospital. The patient was transferred to our tertiary centre for operative mitral valve repair. Transoesophageal echocardiogram revealed the presence of LAA thrombus. During the admission, the patient developed an electrical storm and cardiogenic shock. Because of the extremely high surgical risk and the lack of other therapeutic options, the patient was treated with TMVR (MitraClip\u2122, Abbott Structural Heart Devices, Santa Clara, CA, USA) with the use of CPD (Sentinel\u2122; Boston scientific) as a rescue therapy. After the procedure, the clinical and haemodynamic conditions of the patient improved significantly, and she could be discharged home without any neurological sequelae.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>TMVR with concurrent use of CPD as a rescue therapy may be considered in non-operable patients with cardiogenic shock caused by acute severe MR and evidence of LAA thrombus when no other therapy options are possible.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytab266","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T05:10:20Z","timestamp":1626757820000},"source":"Crossref","is-referenced-by-count":1,"title":["A case report of transcatheter mitral valve repair in patient with severe acute mitral regurgitation, cardiogenic shock, and left atrial appendage thrombus as a rescue therapy: facing all enemies at once!"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5883-2561","authenticated-orcid":false,"given":"Mhd Nawar","family":"Alachkar","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Autschbach","sequence":"additional","affiliation":[{"name":"Department of Heart Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4765-109X","authenticated-orcid":false,"given":"Mohammad","family":"Almalla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"2021072005101429900_ytab266-B1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/heartjnl-2018-313373","article-title":"Acute mitral regurgitation","volume":"105","author":"Watanabe","year":"2019","journal-title":"Heart"},{"key":"2021072005101429900_ytab266-B2","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.athoracsur.2018.03.086","article-title":"Isolated mitral valve surgery: the Society of Thoracic Surgeons adult cardiac surgery database 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