{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:55:48Z","timestamp":1755597348235,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Capnocytophaga canimorsus, a bacterium found in the oral cavities of healthy cats and dogs, is rarely reported as a cause of infective endocarditis. In this report we describe such a case in a young, male dog owner who presented acutely unwell in heart failure.<\/jats:p>\n <\/jats:sec>\n \n Case summary<\/jats:title>\n A 47-year-old male presented with a subacute onset of fever, night sweats, weight loss, dyspnoea, and peripheral oedema. On clinical examination typical features of infective endocarditis, heart failure, and aortic regurgitation were found. The patient had no conventional risk factors for infective endocarditis but was a dog owner. Transthoracic echocardiography revealed vegetations on the right coronary and non-coronary cusps of the aortic valve causing severe eccentric aortic regurgitation and left ventricular dilatation. Initial blood cultures taken prior to the initiation of antimicrobial therapy showed no growth. The patient underwent aortic valve and root replacement and a 16S ribosomal RNA polymerase chain reaction (16S rRNA PCR) of the resected aortic valve tissue, using the additional primer set 785F\/1175R targeting the V5\u20137 region of 16S rRNA, identified C. canimorsus. The patient was treated post-operatively with a 6-week course of meropenem and made a good recovery.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Suspicion of C. canimorsus causing infective endocarditis should be considered in culture-negative infective endocarditis in individuals who have close contact with dogs or cats. Those who are immunocompetent can be susceptible to this infection and so this diagnosis should not be disregarded in healthy individuals. A 16S rRNA PCR can help identify this bacterium and should be used early in cases of culture-negative infective endocarditis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytab278","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T06:19:40Z","timestamp":1628489980000},"source":"Crossref","is-referenced-by-count":5,"title":["Capnocytophaga canimorsus<\/i> and infective endocarditis\u2014making a dog\u2019s dinner of the aortic valve: a case report"],"prefix":"10.1093","volume":"5","author":[{"given":"Anita","family":"Sri","sequence":"first","affiliation":[{"name":"Department of Cardiology, Buckinghamshire NHS Foundation Trust, Queen Alexandra Road, Wycombe, Buckinghamshire HP11 2TT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Droscher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Buckinghamshire NHS Foundation Trust, Queen Alexandra Road, Wycombe, Buckinghamshire HP11 2TT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3004-9089","authenticated-orcid":false,"given":"Rodney","family":"De Palma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Buckinghamshire NHS Foundation Trust, Queen Alexandra Road, Wycombe, Buckinghamshire HP11 2TT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"2021080906181076100_ytab278-B1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3201\/eid1202.050783","article-title":"Diagnosing Capnocytophaga canimorsus infections","volume":"12","author":"Janda","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"2021080906181076100_ytab278-B2","doi-asserted-by":"crossref","first-page":"hi.2009.e5","DOI":"10.4081\/hi.2009.e5","article-title":"Capnocytophaga canimorsus endocarditis with root abscess in a patient with a bicuspid aortic valve","volume":"4","author":"Coutance","year":"2009","journal-title":"Heart Int"},{"key":"2021080906181076100_ytab278-B3","doi-asserted-by":"crossref","first-page":"e233721","DOI":"10.1136\/bcr-2019-233721","article-title":"Tricuspid valve endocarditis due to Capnocytophaga canimorsus","volume":"12","author":"Cardoso","year":"2019","journal-title":"BMJ Case Rep"},{"key":"2021080906181076100_ytab278-B4","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0828-282X(09)70076-5","article-title":"Man\u2019s best friend? 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