{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:39:31Z","timestamp":1790185171884,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Transcatheter aortic valve implantation (TAVI) has proven efficacy in the treatment of aortic stenosis (AS). Understandably, there is increasing enthusiasm for its use to treat aortic regurgitation (AR). However, there are significant anatomical differences between AS and AR which make TAVI for AR more complex.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present the case of technically challenging TAVI for severe AR, which was complicated by a traumatic ventricular septal defect (VSD) that required percutaneous closure. To our knowledge, this is the first published case of VSD post-TAVI for AR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This unanticipated complication highlights anatomical differences between TAVI use in AS and AR. Lack of aortic valve calcification and excessive annular compliance made stable deployment of a self-expanding valve extremely challenging. Despite device oversizing, repeated embolization of the prosthesis into the left ventricular outflow tract traumatized the interventricular septum.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytab387","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T22:23:08Z","timestamp":1633472588000},"source":"Crossref","is-referenced-by-count":3,"title":["A case report of ventricular septal defect complicating transcatheter aortic valve implant for aortic regurgitation: novel complication and technical considerations"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8066-1914","authenticated-orcid":false,"given":"Jack","family":"Hartnett","sequence":"first","affiliation":[{"name":"Department of Cardiology, St James's Hospital, James's Street, Dublin 8 D08 W9RT, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5833-1986","authenticated-orcid":false,"given":"Lisa","family":"Brandon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St James's Hospital, James's Street, Dublin 8 D08 W9RT, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"Waterhouse","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Blackrock Clinic, Rock Road, Blackrock, Co Dublin A94 E4X7, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross T","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St James's Hospital, James's Street, Dublin 8 D08 W9RT, Ireland"},{"name":"Department of Cardiology, Blackrock Clinic, Rock Road, Blackrock, Co Dublin A94 E4X7, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Our Lady's Children's Hospital Crumlin, Dublin 12 D12 N512, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S","family":"Spence","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Victoria Hospital, Belfast Trust, 274 Grosvenor Road, Belfast BT12 6BA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0002-5828","authenticated-orcid":false,"given":"Andrew O","family":"Maree","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St James's Hospital, James's Street, Dublin 8 D08 W9RT, Ireland"},{"name":"Department of Cardiology, Blackrock Clinic, Rock Road, Blackrock, Co Dublin A94 E4X7, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"2021101408371435700_ytab387-B1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery","volume":"363","author":"Leon","year":"2010","journal-title":"N Engl J Med"},{"key":"2021101408371435700_ytab387-B2","first-page":"e72","article-title":"2020 ACC\/AHA Guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"2021101408371435700_ytab387-B3","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1016\/j.mayocp.2020.07.030","article-title":"Transcatheter aortic valve replacement vs surgical replacement in patients with pure aortic insufficiency","volume":"95","author":"Alharbi","year":"2020","journal-title":"Mayo Clin Proc"},{"key":"2021101408371435700_ytab387-B4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ccd.29189","article-title":"Short-term outcomes of transcatheter aortic valve replacement for pure native aortic regurgitation in the United States","volume":"97","author":"Isogai","year":"2021","journal-title":"Catheter Cardiovasc Interv"},{"key":"2021101408371435700_ytab387-B5","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.hlc.2019.04.012","article-title":"Meta-analysis and meta-regression of transcatheter aortic valve implantation for pure native aortic regurgitation","volume":"29","author":"Takagi","year":"2020","journal-title":"Heart Lung Circ"},{"key":"2021101408371435700_ytab387-B6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jtcvs.2018.03.038","article-title":"Transcatheter aortic valve replacement for isolated aortic regurgitation is coming!","volume":"156","author":"Ye","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2021101408371435700_ytab387-B7","first-page":"229","article-title":"Expansion of the indication of transcatheter aortic valve implantation\u2013feasibility and outcome in \u201coff-label\u201d patients compared with \u201con-label\u201d patients","volume":"27","author":"Frerker","year":"2015","journal-title":"J Invasive Cardiol"},{"key":"2021101408371435700_ytab387-B8","doi-asserted-by":"crossref","first-page":"739","DOI":"10.4244\/EIJV10I6A127","article-title":"CoreValve implantation for severe aortic regurgitation: a multicentre registry","volume":"10","author":"Testa","year":"2014","journal-title":"EuroIntervention"},{"key":"2021101408371435700_ytab387-B9","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1016\/j.jacc.2017.10.006","article-title":"Transcatheter aortic valve replacement in pure native aortic valve regurgitation","volume":"70","author":"Yoon","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2021101408371435700_ytab387-B10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s11886-020-01338-6","article-title":"TAVR in patients with pure aortic regurgitation: ready to use?","volume":"22","author":"Markham","year":"2020","journal-title":"Curr Cardiol Rep"},{"key":"2021101408371435700_ytab387-B11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ijcard.2017.05.120","article-title":"Effect of ascending aortic dimension on acute procedural success following self-expanding transcatheter aortic valve replacement: a multicenter retrospective analysis","volume":"244","author":"Maeno","year":"2017","journal-title":"Int J Cardiol"},{"key":"2021101408371435700_ytab387-B12","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.jcmg.2016.02.030","article-title":"Aortic angulation attenuates procedural success following self-expandable but not balloon-expandable TAVR","volume":"9","author":"Abramowitz","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"2021101408371435700_ytab387-B13","first-page":"yty013","article-title":"Percutaneous closure of a combined ventricular septal defect and paravalvular regurgitation after transcatheter aortic valve implantation: case report","volume":"2","author":"Kooistra","year":"2018","journal-title":"Eur Heart J Case Rep"},{"key":"2021101408371435700_ytab387-B14","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.hlc.2016.03.012","article-title":"Iatrogenic ventricular septal defect following transcatheter aortic valve replacement: a systematic review","volume":"25","author":"Ando","year":"2016","journal-title":"Heart Lung Circ"},{"key":"2021101408371435700_ytab387-B15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/24748706.2018.1434580","article-title":"Ventricular septal defect as a complication of TAVI: mechanism and incidence","volume":"2","author":"Zeniou","year":"2018","journal-title":"Struct Heart"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytab387\/40509736\/ytab387.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/10\/ytab387\/40636353\/ytab387.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/10\/ytab387\/40636353\/ytab387.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T10:02:06Z","timestamp":1634551326000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytab387\/6381597"}},"subtitle":[],"editor":[{"given":"Pierre","family":"Deharo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Giulio","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Ciro","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Stefan","family":"Simovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Nida","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,1]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytab387","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10,1]]},"published":{"date-parts":[[2021,10,1]]},"article-number":"ytab387"}}