{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:24:01Z","timestamp":1760300641633,"version":"3.41.2"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Deglutition-induced atrial fibrillation is a rare clinical entity with a reported prevalence of 0.6%. Laing distal myopathy is a rare autosomal dominant muscular dystrophy that is the result of mutations within the slow skeletal muscle fibre myosin heavy chain gene (MYH7). Atrial fibrillation has not been previously reported in patients with Laing distal myopathy. We describe the first reported case of deglutition triggered atrial fibrillation in a female with a history of Laing distal myopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>A 44-year-old female with a history of Laing distal myopathy diagnosed at age 32, began experiencing intermittent episodes of pre-syncope and palpitations which occurred after deglutition with food. An ambulatory 30-day patient triggered event monitor recorded episodes of atrial fibrillation with rapid ventricular response. Family history was significant for Laing distal myopathy, atrial fibrillation, as well as sudden cardiac death. Laboratory data, transthoracic echocardiogram, cardiac magnetic resonance imaging, and an exercise treadmill SPECT Imaging stress test were normal. An oesophagram revealed a mild oesophageal dysmotility with no other abnormalities. She was started on flecainide 50 mg p.o. every 8 h and verapamil 40 mg p.o. every 8 h with no further episodes of atrial fibrillation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Given the strong genetic component of this myopathy, one could postulate as to a possible genetic component in the development of atrial fibrillation in our patient. Although we cannot make definite correlation between deglutition-induced atrial fibrillation and Laing myopathy, it is important to report this unusual association which has not been described before.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ehjcr\/ytab430","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T13:19:07Z","timestamp":1635686347000},"source":"Crossref","is-referenced-by-count":1,"title":["A case report of deglutition triggered atrial fibrillation in a patient with Laing distal myopathy"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2664-6371","authenticated-orcid":false,"given":"Chikezie K","family":"Alvarez","sequence":"first","affiliation":[{"name":"Cardiovascular Department, Hartford Hospital\/University of Connecticut, 80 Seymour St, Hartford, CT 06106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-7059","authenticated-orcid":false,"given":"Heather","family":"Swales","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Hartford Hospital\/University of Connecticut, 80 Seymour St, Hartford, CT 06106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Kluger","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Hartford Hospital\/University of Connecticut, 80 Seymour St, Hartford, CT 06106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"2021121512331095200_ytab430-B1","first-page":"ytx004","article-title":"Swallowing-induced atrial tachycardia in an adolescent with hypertrophic cardiomyopathy: a case report","volume":"1","author":"Challapudi","year":"2017","journal-title":"Eur Hear J Case Rep"},{"key":"2021121512331095200_ytab430-B2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/BF02627765","article-title":"\u00dcber einen Fall von sog. \u201cSchlucktachykardie\u201d","volume":"50","author":"SakaiMori","year":"1926","journal-title":"Z Gesamte Exp Med"},{"key":"2021121512331095200_ytab430-B3","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/j.1540-8159.2007.00844.x","article-title":"Swallowing-induced atrial tachyarrhythmias: prevalence, characteristics, and the results of the radiofrequency catheter ablation","volume":"30","author":"Tada","year":"2007","journal-title":"Pacing Clin Electrophysiol"},{"key":"2021121512331095200_ytab430-B4","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.jacep.2018.07.016","article-title":"Atrial arrhythmias and extensive left atrial fibrosis as the initial presentation of MYH7 gene mutation","volume":"4","author":"Zhang","year":"2018","journal-title":"JACC Clin Electrophysiol"},{"key":"2021121512331095200_ytab430-B5","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/jnnp.2005.073825","article-title":"Laing early onset distal myopathy: slow myosin defect with variable abnormalities on muscle biopsy","volume":"77","author":"Lamont","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2021121512331095200_ytab430-B6","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1001\/archneur.60.9.1321","article-title":"The second kindred with autosomal dominant distal myopathy linked to chromosome 14q: genetic and clinical analysis","volume":"60","author":"Hedera","year":"2003","journal-title":"Arch Neurol"},{"key":"2021121512331095200_ytab430-B7","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/CIRCRESAHA.108.186460","article-title":"Cardiac cytoskeleton and arrhythmia: an unexpected role for protein 4.1R in cardiac excitability","volume":"103","author":"Cunha","year":"2008","journal-title":"Circ Res"},{"key":"2021121512331095200_ytab430-B8","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1161\/CIRCRESAHA.114.302225","article-title":"Emerging directions in the genetics of atrial fibrillation","volume":"114","author":"Tucker","year":"2014","journal-title":"Circ Res"},{"key":"2021121512331095200_ytab430-B9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0022-0736(80)80036-7","article-title":"Swallowing-dependent atrial tachyarrhythmias. Their mechanism","volume":"13","author":"Suarez","year":"1980","journal-title":"J Electrocardiology"},{"key":"2021121512331095200_ytab430-B10","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCRESAHA.113.302549","article-title":"Role of the autonomic nervous system in modulating cardiac arrhythmias","volume":"114","author":"Shen","year":"2014","journal-title":"Circ Res"},{"key":"2021121512331095200_ytab430-B11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3909\/ricm0863","article-title":"Swallowing-induced supraventricular tachyarrhythmia","volume":"18","author":"Khalid","year":"2017","journal-title":"Rev Cardiovasc Med"},{"key":"2021121512331095200_ytab430-B12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/hrt.81.3.313","article-title":"Tachyarrhythmias triggered by swallowing and belching","volume":"81","author":"Wilmshurst","year":"1999","journal-title":"Heart"},{"key":"2021121512331095200_ytab430-B13","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1161\/CIR.0000000000000665","article-title":"2019 AHA\/ACC\/HRS Focused Update of the 2014 AHA\/ACC\/HRS Guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines and the Heart Rhythm Society in collaboration with the Society of Thoracic Surgeons","volume":"140","author":"January","year":"2019","journal-title":"Circulation"},{"key":"2021121512331095200_ytab430-B14","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.hrthm.2006.04.010","article-title":"Radiofrequency ablation of swallowing-induced atrial tachycardia: case report and review of literature","volume":"3","author":"Undavia","year":"2006","journal-title":"Heart Rhythm"},{"key":"2021121512331095200_ytab430-B15","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/j.1540-8167.2005.00249.x","article-title":"Curative therapy for swallowing-induced tachycardia by pulmonary vein antrum isolation","volume":"16","author":"Yamauchi","year":"2005","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2021121512331095200_ytab430-B16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1161\/CIRCEP.111.964262","article-title":"Catheter ablation of right atrial ganglionated plexi in patients with vagal paroxysmal atrial fibrillation","volume":"5","author":"Cal\u00f2","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytab430\/40978249\/ytab430.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/12\/ytab430\/41767008\/ytab430.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/5\/12\/ytab430\/41767008\/ytab430.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T06:23:13Z","timestamp":1673677393000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytab430\/6413634"}},"subtitle":[],"editor":[{"given":"Patrick","family":"Badertscher","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Ying Xuan","family":"Gue","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Francisco Moscoso","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Marco","family":"Vitolo","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Brett Sydney","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Aiste Monika","family":"Jakstaite","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,28]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytab430","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2021,12,1]]},"published":{"date-parts":[[2021,10,28]]},"article-number":"ytab430"}}