{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:16:36Z","timestamp":1788891396220,"version":"build-2803163510"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>IgG4-related disease (IgG4-RD) is a fibro-inflammatory condition classically causing retroperitoneal fibrosis, aortitis, thyroiditis, or pancreatitis. Diagnosis includes the presence of lymphoplasmacytic infiltrate (with &amp;gt;40% ratio IgG4+:IgG plasma cells) and fibrosis. Cardiac involvement may include aortic, pericardial, or coronary disease. Coronary manifestations encompass obstructive intra-luminal lesions, external encasing pseudo-tumour on imaging, or lymphoplasmacytic arteritis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>Case 1: A fit and healthy 50-year-old man was found deceased. His only known medical condition was treated Hashimoto\u2019s thyroiditis. Post-mortem examination demonstrated an isolated severe stenosis of the left anterior descending (LAD) coronary artery without histopathological evidence of acute myocardial infarction. Coronary plaque histopathology showed florid IgG4-positive plasma cell infiltrate throughout all layers of the artery with dense fibrous tissue connective tissue stroma, all features consistent with coronary artery IgG4-RD. Case 2: A 48-year-old man collapsed at work. Computed tomography scan 1 week prior reported an ill-defined para-aortic retroperitoneal soft tissue density. No cardiac symptoms were reported in life. Post-mortem examination showed coronary arteritis and peri-arteritis with sclerosing peri-aortitis in the LAD. There was myocardial fibrosis of the anterior left ventricle and focal myocarditis of the right ventricle.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>IgG4-related disease presenting as sudden cardiac death without any preceding symptoms is very rare (six prior cases identified on literature review). Reported targeted successful interventions for intracoronary IgG4-RD diagnosed in life have included steroid therapy and B cell depleting therapy (i.e. rituximab). If cardiac symptoms are present in a patient with known IgG4-RD, cardiac investigations should be promptly arranged.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac050","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T21:35:49Z","timestamp":1644356149000},"source":"Crossref","is-referenced-by-count":11,"title":["Intracoronary IgG4-related disease as an unusual cause of sudden cardiac arrest: a case series"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2122-9889","authenticated-orcid":false,"given":"Elizabeth D","family":"Paratz","sequence":"first","affiliation":[{"name":"Department of Cardiology, Baker Heart and Diabetes Institute, 75 Commercial Road, Prahran, VIC 3181, Australia"},{"name":"Department of Cardiology, Alfred Hospital, 55 Commercial Road, Prahran, VIC 3181, Australia"},{"name":"Department of Cardiology, St Vincent\u2019s Hospital Melbourne, 41 Victoria Pde, Fitzroy. VIC 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4636-729X","authenticated-orcid":false,"given":"Laura","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St Vincent\u2019s Hospital Melbourne, 41 Victoria Pde, Fitzroy. VIC 3065, Australia"},{"name":"Department of Rheumatology, St Vincent\u2019s Hospital Melbourne, 41 Victoria Pde, Fitzroy, VIC 3065, Australia"},{"name":"Department of Medicine, The University of Melbourne at St Vincent\u2019s, 41 Victoria Pde, Fitzroy, VIC 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-1581","authenticated-orcid":false,"given":"Dominica","family":"Zentner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Melbourne Hospital, 300 Grattan Street, Parkville, VIC 3050, Australia"},{"name":"Department of Cardiology, Royal Melbourne Hospital Clinical School, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8198-5723","authenticated-orcid":false,"given":"Natalie","family":"Morgan","sequence":"additional","affiliation":[{"name":"Victorian Institute of Forensic Medicine, 65 Kavanagh Street, Southbank, VIC 3006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Bouwer","sequence":"additional","affiliation":[{"name":"Victorian Institute of Forensic Medicine, 65 Kavanagh Street, Southbank, VIC 3006, Australia"},{"name":"Department of Forensic Medicine, Monash University, 65 Kavanagh Street, Southbank, VIC 3006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Lynch","sequence":"additional","affiliation":[{"name":"Victorian Institute of Forensic Medicine, 65 Kavanagh Street, Southbank, VIC 3006, Australia"},{"name":"Department of Forensic Medicine, Monash University, 65 Kavanagh Street, Southbank, VIC 3006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1238-1360","authenticated-orcid":false,"given":"Sarah","family":"Parsons","sequence":"additional","affiliation":[{"name":"Victorian Institute of Forensic Medicine, 65 Kavanagh Street, Southbank, VIC 3006, Australia"},{"name":"Department of Forensic Medicine, Monash University, 65 Kavanagh Street, Southbank, VIC 3006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-3784","authenticated-orcid":false,"given":"Andre","family":"La Gerche","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Baker Heart and Diabetes Institute, 75 Commercial Road, Prahran, VIC 3181, Australia"},{"name":"Department of Cardiology, Alfred Hospital, 55 Commercial Road, Prahran, VIC 3181, Australia"},{"name":"Department of Cardiology, St Vincent\u2019s Hospital Melbourne, 41 Victoria Pde, Fitzroy. 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