{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:06:47Z","timestamp":1757455607836,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Diagnosis of fungal endocarditis can be challenging, especially among cases with negative blood culture results. Of fungal endocarditis cases, Histoplasma capsulatum constitutes an even smaller proportion with \u223c58 prior cases reported. Due to the rarity of histoplasmosis endocarditis and thus limited data, there is no current diagnostic guideline for testing within culture negative infective endocarditis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>Our patient was a 58-year-old female presenting with worsening dyspnoea, hypotension, and near-syncope. In this case report, we depict the clinical presentation and diagnosis of H. capsulatum endocarditis in a female patient with a prosthetic aortic valve and negative blood cultures. We further demonstrate the rising risk of fungal endocarditis with use of external devices.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Despite the rarity of fungal endocarditis, there has been a recent upward trend in infections given the rising use of external devices, greater number of immunocompromised patients, and rising rates of intravenous drug use. Recently, more cases of fungal endocarditis have been occurring in patients with prosthetic valves compared to native. Although H. capsulatum constitutes a smaller proportion of fungal endocarditis cases, patients with appropriate risk factors and those who have been exposed to at-risk areas such as the Ohio and Mississippi River valleys, may benefit from further evaluation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac086","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T13:59:56Z","timestamp":1645797596000},"source":"Crossref","is-referenced-by-count":3,"title":["Rare case of <i>Histoplasma capsulatum<\/i> endocarditis in a patient with a prosthetic valve"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5204-7239","authenticated-orcid":false,"given":"Emily M","family":"Manning","sequence":"first","affiliation":[{"name":"Case Western Reserve University School of Medicine, Health Education Campus, 9501 Euclid Ave, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8659-617X","authenticated-orcid":false,"given":"Benjamin","family":"Zorach","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4413-5439","authenticated-orcid":false,"given":"Anirudh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"2022030213104172000_ytac086-B1","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.amjmed.2016.05.012","article-title":"Fungal endocarditis: update on diagnosis and management","volume":"129","author":"Pasha","year":"2016","journal-title":"Am J Med"},{"key":"2022030213104172000_ytac086-B2","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1111\/jocs.14656","article-title":"Optimizing outcomes in infective endocarditis: a comprehensive literature review","volume":"35","author":"Harky","year":"2020","journal-title":"J Card Surg"},{"key":"2022030213104172000_ytac086-B3","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIR.0000000000000296","article-title":"Infective endocarditis in adults: Diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association: a scientific statement for healthcare professionals from the American heart association","volume":"132","author":"Baddour","year":"2015","journal-title":"Circulation"},{"key":"2022030213104172000_ytac086-B4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/MD.0000000000000034","article-title":"Histoplasma capsulatum endocarditis: multicenter case series with review of current diagnostic techniques and treatment","volume":"93","author":"Riddell","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"2022030213104172000_ytac086-B5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3201\/eid2403.171258","article-title":"Multistate epidemiology of histoplasmosis, United States, 2011-2014","volume":"24","author":"Armstrong","year":"2018","journal-title":"Emerg Infect Dis"},{"key":"2022030213104172000_ytac086-B6","doi-asserted-by":"crossref","first-page":"ofx241","DOI":"10.1093\/ofid\/ofx241","article-title":"Diagnostic importance of hyphae on heart valve tissue in Histoplasma endocarditis and treatment with isavuconazole","volume":"4","author":"Wiley","year":"2017","journal-title":"Open Forum Infect Dis"},{"year":"2021","author":"Centers for Disease Control and Prevention","key":"2022030213104172000_ytac086-B7"},{"key":"2022030213104172000_ytac086-B8","doi-asserted-by":"crossref","first-page":"4664","DOI":"10.1128\/JCM.01390-10","article-title":"Histoplasma capsulatum prosthetic valve endocarditis with negative fungal blood cultures and negative histoplasma antigen assay in an immunocompetent patient","volume":"48","author":"Jinno","year":"2010","journal-title":"J Clin Microbiol"},{"key":"2022030213104172000_ytac086-B9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4103\/jcecho.jcecho_53_19","article-title":"Infective endocarditis: Echocardiographic imaging and new imaging modalities","volume":"29","author":"Sordelli","year":"2019","journal-title":"J Cardiovasc Echogr"},{"key":"2022030213104172000_ytac086-B10","doi-asserted-by":"crossref","first-page":"e010287","DOI":"10.1161\/JAHA.118.010287","article-title":"Infective endocarditis after transcatheter aortic valve replacement: the worst that can happen","volume":"7","author":"Habib","year":"2018","journal-title":"J Am Heart Assoc"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytac086\/42614445\/ytac086.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/3\/ytac086\/42675006\/ytac086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/3\/ytac086\/42675006\/ytac086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T13:11:03Z","timestamp":1646226663000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytac086\/6536964"}},"subtitle":[],"editor":[{"given":"Hatem Soliman","family":"Aboumarie","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Al-Hijji","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Ali Nazmi","family":"Calik","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Megha","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Ayse","family":"Djahit","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytac086","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2022,3,1]]},"published":{"date-parts":[[2022,2,25]]},"article-number":"ytac086"}}