{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:34Z","timestamp":1753876234307,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Ministry of Health, Czech Republic","award":["NV19-08-00122"],"award-info":[{"award-number":["NV19-08-00122"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pheochromocytoma is a neuroendocrine tumour originating from the chromaffin cells of adrenal glands or sympathetic paraganglia. It produces most frequently norepinephrine, epinephrine, and dopamine. As a result of non-specific and variable clinical presentation, pheochromocytoma is difficult to diagnose.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 37-year-old female without medical history and 57-year-old male patient with diabetes, arterial hypertension, and aortic valve replacement with a mechanical prosthesis were admitted to the hospital after successful cardiopulmonary resuscitation due to ventricular fibrillation. In both patients, coronary angiography demonstrated a normal finding, and echocardiography showed left ventricular (LV) contractile dysfunction with improvement in the subsequent examination. In the first patient, the diagnosis of stress-induced cardiomyopathy was considered as the most probable cause. She was later admitted to hospital due to acute pulmonary oedema with hypertensive crisis. Echocardiography documented reversible LV systolic dysfunction with improvement after 3\u2009days. The course of hospitalization of the male was complicated by multi-organ dysfunction syndrome comprising renal failure, paralytic ileus, and pancreatic irritation, which normalized after 2\u2009weeks. The diagnosis of pheochromocytoma was confirmed by laboratory tests and imaging methods. After pharmacological pre-treatment with doxazosin in both patients and bisoprolol in the female, successful adrenalectomies were performed with no relapse of tumour.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>We describe an atypical clinical presentation of pheochromocytoma with initial cardiac arrest due to ventricular fibrillation and reversible LV systolic dysfunction. Our cases underline that clinical suspicion of pheochromocytoma as a potentially correctable cause should be raised in unexplained cases of severe heart failure, ventricular arrhythmias, and cardiac arrest.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac098","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T08:06:02Z","timestamp":1646640362000},"source":"Crossref","is-referenced-by-count":1,"title":["Adrenal pheochromocytoma as a rare cause of reversible left ventricular systolic dysfunction and malignant arrhythmias: a case series"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-8460","authenticated-orcid":false,"given":"Dominik","family":"Jen\u010da","sequence":"first","affiliation":[{"name":"Department of Cardiology, Institute for Clinical and Experimental Medicine , V\u00edde\u0148sk\u00e1 1958\/9, Prague, Czech Republic"},{"name":"Third Faculty of Medicine, Charles University , Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milo\u0161","family":"Kub\u00e1nek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute for Clinical and Experimental Medicine , V\u00edde\u0148sk\u00e1 1958\/9, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9018-1738","authenticated-orcid":false,"given":"Michal","family":"Kudla","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery, Institute for Clinical and Experimental Medicine , Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevenka","family":"Solar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Institute for Clinical and Experimental Medicine , Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1632-6182","authenticated-orcid":false,"given":"Josef","family":"Kautzner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institute for Clinical and Experimental Medicine , V\u00edde\u0148sk\u00e1 1958\/9, Prague, Czech Republic"},{"name":"Faculty of Medicine and Dentistry, Palack\u00fd University , Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"2022081608474821400_ytac098-B1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.amjsurg.2010.04.012","article-title":"Malignant pheochromocytoma: a review","volume":"201","author":"Harari","year":"2011","journal-title":"Am J Surg"},{"key":"2022081608474821400_ytac098-B2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ijcard.2017.07.014","article-title":"Pheochromocytoma as a reversible cause of cardiomyopathy: analysis and review of the literature","volume":"249","author":"Zhang","year":"2017","journal-title":"Int J Cardiol"},{"key":"2022081608474821400_ytac098-B3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mce.2017.06.016","article-title":"Epigenetics of pheochromocytoma and paraganglioma","volume":"469","author":"Bj\u00f6rklund","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"2022081608474821400_ytac098-B4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.maturitas.2013.12.009","article-title":"Pheochromocytoma: a review","volume":"77","author":"Tsirlin","year":"2014","journal-title":"Maturitas"},{"key":"2022081608474821400_ytac098-B5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijscr.2018.06.024","article-title":"Adrenergic cardiomyopathy and cardiogenic shock as initial presentation of pheochromocytoma. A case report and review of the literature","volume":"49","author":"Gil-Barrionuevo","year":"2018","journal-title":"Int J Surg Case Rep"},{"key":"2022081608474821400_ytac098-B6","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.resuscitation.2009.07.012","article-title":"Sudden cardiac arrest after minor abdominal trauma: a successful resuscitation in a patient with haemorrhagic phaeochromocytoma","volume":"80","author":"Chiu","year":"2009","journal-title":"Resuscitation"},{"key":"2022081608474821400_ytac098-B7","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00540-016-2281-3","article-title":"A successfully treated case of cardiac arrest after Caesarean section complicated by pheochromocytoma crisis and amniotic fluid embolism","volume":"31","author":"Mita","year":"2017","journal-title":"J Anesth"},{"key":"2022081608474821400_ytac098-B8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.currproblcancer.2014.01.001","article-title":"Pheochromocytoma and paraganglioma: diagnosis, genetics, management, and treatment","volume":"38","author":"Martucci","year":"2014","journal-title":"Curr Probl Cancer"},{"key":"2022081608474821400_ytac098-B9","first-page":"196","article-title":"Laparoscopic surgery for malignant adrenal tumors","volume":"13","author":"Zografos","year":"2009","journal-title":"JSLS"},{"key":"2022081608474821400_ytac098-B10","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.surg.2014.08.044","article-title":"Predictors of recurrence in pheochromocytoma","volume":"156","author":"Press","year":"2014","journal-title":"Surgery"},{"key":"2022081608474821400_ytac098-B11","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J Clin Endocrinol Metab"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/3\/ytac098\/45438008\/ytac098.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/3\/ytac098\/45438008\/ytac098.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T08:48:23Z","timestamp":1660639703000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytac098\/6542426"}},"subtitle":[],"editor":[{"given":"Ching-Hui","family":"Sia","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Andriana","family":"Anagnostopoulou","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Richard","family":"Ang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Reshma","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Nida","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytac098","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2022,3,1]]},"published":{"date-parts":[[2022,3,1]]},"article-number":"ytac098"}}