{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:37:39Z","timestamp":1773149859196,"version":"3.50.1"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Primary cardiac tumours are extremely rare with an autopsy incidence of 0.05%. They can present with a variety of symptoms, including life-threatening arrhythmia and cardiac tamponade. In this case report, we focus on the diagnostic process and management of a primary cardiac lymphoma (PCL) presenting with cardiac tamponade.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We report on a 71-year-old male presenting with a large pericardial effusion, tamponade, and a mass in the right atrioventricular groove. Multimodality imaging was performed, including transthoracic echocardiography, computed tomography, magnetic resonance imaging, positron emission tomography, and computed tomography-guided transthoracic biopsy. The final diagnosis of a double-hit diffuse large-cell B-cell lymphoma was made, for which treatment consisting of a combination of chemotherapy and immunotherapy was initiated. Low-dose colchicine was also added to the treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Primary cardiac lymphoma remains a very rare diagnosis and this case highlights the need for multimodality imaging and imaging-guided biopsy to differentiate cardiac masses. First-line treatment for PCL remains a combination of chemotherapy with immunotherapy, with the addition of low-dose colchicine to prevent recurrence of malignant pericardial effusion.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac151","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T08:42:48Z","timestamp":1649493768000},"source":"Crossref","is-referenced-by-count":6,"title":["Primary cardiac diffuse large B-cell lymphoma presenting with cardiac tamponade: a case report"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6593-2592","authenticated-orcid":false,"given":"Laurens","family":"Berton","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sint-Trudo Hospital , Diestersteenweg 100, 3800 Sint-Truiden, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6881-7533","authenticated-orcid":false,"given":"Valerie","family":"Van Ballaer","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jessa Hospital , 3500 Hasselt, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Ghekiere","sequence":"additional","affiliation":[{"name":"Department of Radiology, Jessa Hospital , 3500 Hasselt, Belgium"},{"name":"Faculty of Medicine and Life Sciences, Cardiology and Organ systems, Hasselt University , 3500 Hasselt, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4399-4335","authenticated-orcid":false,"given":"Eva","family":"De Caluw\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sint-Trudo Hospital , 3800 Sint-Truiden, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,9]]},"reference":[{"key":"2022053123240274200_ytac151-B1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0002-9149(97)89149-7","article-title":"Frequency of primary tumors of the heart","volume":"77","author":"Reynen","year":"1996","journal-title":"Am J Cardiol"},{"key":"2022053123240274200_ytac151-B2","first-page":"1027","article-title":"Tumors of the heart. A 20-year experience with a review of 12,485 consecutive autopsies","volume":"117","author":"Lam","year":"1993","journal-title":"Arch Pathol Lab Med"},{"key":"2022053123240274200_ytac151-B3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ijcard.2010.02.016","article-title":"Primary cardiac lymphoma","volume":"149","author":"Miguel","year":"2011","journal-title":"Int J Cardiol"},{"key":"2022053123240274200_ytac151-B4","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/cncr.25444","article-title":"Primary cardiac lymphoma: an analysis of presentation, treatment, and outcome patterns","volume":"117","author":"Petrich","year":"2011","journal-title":"Cancer"},{"key":"2022053123240274200_ytac151-B5","first-page":"201","article-title":"Non-hodgkin lymphoma and Guillain-Barr\u00e9 syndrome: a rare association","volume":"8","author":"Seffo","year":"2010","journal-title":"Clin Adv Hematol Oncol"},{"key":"2022053123240274200_ytac151-B6","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s00259-013-2436-5","article-title":"Imaging characteristics of cardiac dominant diffuse large B-cell lymphoma demonstrated with MDCT and PET\/CT","volume":"40","author":"Kikuchi","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2022053123240274200_ytac151-B7","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1200\/JCO.2013.54.8800","article-title":"Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification","volume":"32","author":"Cheson","year":"2014","journal-title":"J Clin Oncol"},{"key":"2022053123240274200_ytac151-B8","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1056\/NEJMra2027612","article-title":"Diffuse large B-cell lymphoma","volume":"384","author":"Sehn","year":"2021","journal-title":"N Engl J Med"},{"key":"2022053123240274200_ytac151-B9","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.jacc.2020.08.003","article-title":"Effect of anti-inflammatory drugs on clinical outcomes in patients with malignant pericardial effusion","volume":"76","author":"Kim","year":"2020","journal-title":"J Am Coll Cardiol"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytac151\/43348988\/ytac151.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/5\/ytac151\/43616377\/ytac151.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/5\/ytac151\/43616377\/ytac151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T23:24:26Z","timestamp":1654039466000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytac151\/6565742"}},"subtitle":[],"editor":[{"given":"Suzan","family":"Hatipoglu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Annagrazia","family":"Cecere","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Erica","family":"Tirr","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Oliver","family":"Ian Brown","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Vervaat","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,9]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytac151","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,5,1]]},"published":{"date-parts":[[2022,4,9]]},"article-number":"ytac151"}}