{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:08:15Z","timestamp":1790716095256,"version":"4.1.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Postural orthostatic tachycardia syndrome (POTS), Ehlers-Danlos syndrome (EDS), and May-Thurner syndrome (MTS) are three syndromes that are often misdiagnosed or underdiagnosed. The true prevalence of these syndromes may be higher than currently reported. The following case series is the first to report a three-way association between POTS, EDS, and MTS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We describe three patients with concomitant POTS, EDS, and MTS. Although abdominopelvic vasculature evaluation can be difficult via conventional imaging techniques, we present the use of novel dynamic contrast-enhanced magnetic resonance angiography with Differential Subsampling with Cartesian Ordering (DISCO) and four-dimensional flow magnetic resonance imaging to aid vasculature evaluation and the diagnosis of MTS. Two patients underwent left common iliac vein stenting to treat MTS, experiencing significant improvement in their POTS symptoms and quality of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Ehlers-Danlos syndrome, POTS, and MTS may interact synergistically to exacerbate symptoms. Patients with EDS should be evaluated for possible POTS and pelvic venous complications. Left common iliac vein stenting for MTS can mitigate POTS symptoms by decreasing lower extremity venous pooling and should be considered in this patient population. Further research is needed to understand the exact mechanism and intricacies of this syndrome triad.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac161","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T08:42:38Z","timestamp":1649493758000},"source":"Crossref","is-referenced-by-count":13,"title":["May-Thurner syndrome in patients with postural orthostatic tachycardia syndrome and Ehlers-Danlos syndrome: a case series"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-616X","authenticated-orcid":false,"given":"Cameron K.","family":"Ormiston","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of California, 9300 Campus Point Drive Mail Code #7414, San Diego, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0939-7089","authenticated-orcid":false,"given":"Erika","family":"Padilla","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of California, 9300 Campus Point Drive Mail Code #7414, San Diego, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-0226","authenticated-orcid":false,"given":"David T.","family":"Van","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of California, 9300 Campus Point Drive Mail Code #7414, San Diego, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7204-8666","authenticated-orcid":false,"given":"Christine","family":"Boone","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, 200 W Arbor Dr, MC 0834, San Diego, CA 92103-0834, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4098-1355","authenticated-orcid":false,"given":"Sophie","family":"You","sequence":"additional","affiliation":[{"name":"University of California, San Diego School of Medicine, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0911-6512","authenticated-orcid":false,"given":"Anne C.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, 200 W Arbor Dr, MC 0834, San Diego, CA 92103-0834, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9412-1369","authenticated-orcid":false,"given":"Albert","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, 200 W Arbor Dr, MC 0834, San Diego, CA 92103-0834, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-0655","authenticated-orcid":false,"given":"Pam R.","family":"Taub","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of California, 9300 Campus Point Drive Mail Code #7414, San Diego, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,9]]},"reference":[{"key":"2022042507434051800_ytac161-B1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jacc.2020.12.029","article-title":"Randomized trial of ivabradine in patients with hyperadrenergic postural orthostatic tachycardia syndrome","volume":"77","author":"Taub","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2022042507434051800_ytac161-B2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0002-9343(03)00235-3","article-title":"Dysautonomia 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