{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:11:57Z","timestamp":1761419517695,"version":"3.41.2"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020013","name":"NIHR Leicester Biomedical Research Centre","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020013","id-type":"DOI","asserted-by":"crossref"}]},{"name":"British Heart Foundation Programme","award":["RG\/17\/3\/32774"],"award-info":[{"award-number":["RG\/17\/3\/32774"]}]},{"name":"Medical Research Council Biomedical Catalyst Developmental Pathway Funding Scheme","award":["MR\/S037306\/1"],"award-info":[{"award-number":["MR\/S037306\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Minimizing right ventricular (RV) pacing to reduce the progression of heart failure is an established practice. Proprietary algorithms to reduce unnecessary RV pacing have been incorporated into both simple and complex cardiac pacemaker devices, for reducing the possibility of heart failure and arrhythmias.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present a case of a 43-year-old male implanted with a dual-chamber primary prevention implantable cardioverter-defibrillator (AUTOGEN EL, Boston Scientific) for sudden cardiac death. At the time of implant, the patient had hypertrophic cardiomyopathy with mild left ventricular (LV) systolic impairment, and sinus rhythm with intact atrioventricular (AV) conduction. The patient developed progression of his disease with symptoms (dyspnoea) and LV impairment. This led to a decision to activate the minimal RV pacing algorithm (RYTHMIQ\u2122). A deterioration in AV conduction caused intrinsic ventricular beats to fall in the atrial blanking period, and subsequent VVI backup pacing resulted in R on T pacing. This induced ventricular arrhythmia. RYTHMIQ\u2122 was subsequently deactivated, and the patient has had no further device-induced arrhythmias.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Numerous studies have demonstrated the adverse effect of RV pacing on LV function. Minimizing RV pacing is, therefore, encouraged in individuals with intact AV conduction. However, underlying conduction abnormalities must be assessed prior to activating algorithms designed to minimize RV pacing. This case demonstrates the importance of careful intracardiac electrogram interpretation and individual case-based device programming, to avoid device-induced complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac189","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T17:14:26Z","timestamp":1651770866000},"source":"Crossref","is-referenced-by-count":1,"title":["Iatrogenic pacemaker-induced ventricular arrhythmia: a case report"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9612-1947","authenticated-orcid":false,"given":"Vivetha","family":"Pooranachandran","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, Leicester, UK"},{"name":"NIHR Leicester Biomedical Research Centre, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Hodson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospitals of Leicester NHS Trust, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5718-8767","authenticated-orcid":false,"given":"Will","family":"Nicolson","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, Leicester, UK"},{"name":"Department of Cardiology, University Hospitals of Leicester NHS Trust, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5965-0671","authenticated-orcid":false,"given":"Ghulam Andre","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, University of Leicester, Leicester, UK"},{"name":"NIHR Leicester Biomedical Research Centre, Leicester, UK"},{"name":"Department of Cardiology, University Hospitals of Leicester NHS Trust, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"2022051715243928100_ytac189-B1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.amjcard.2004.11.034","article-title":"Effect of chronic right ventricular apical pacing on left ventricular function","volume":"95","author":"O'Keefe","year":"2005","journal-title":"Am J Cardiol"},{"key":"2022051715243928100_ytac189-B2","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/ERP-19-0050","article-title":"Normal reference intervals for cardiac dimensions and function for use in echocardiographic practice: a guideline from the British Society of Echocardiography","volume":"7","author":"Harkness","year":"2020","journal-title":"Echo Res Pract"},{"key":"2022051715243928100_ytac189-B3","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1093\/eurheartj\/eht150","article-title":"2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA)","volume":"34","author":"Authors\/Task Force Members","year":"2013","journal-title":"Eur Heart J"},{"key":"2022051715243928100_ytac189-B4","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/ehf2.12315","article-title":"Rationale and design of the randomized multicentre His Optimized Pacing Evaluated for Heart Failure (HOPE-HF) trial","volume":"5","author":"Keene","year":"2018","journal-title":"ESC Heart Fail"},{"key":"2022051715243928100_ytac189-B5","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1001\/jama.288.24.3115","article-title":"Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial","volume":"288","author":"Wilkoff","year":"2002","journal-title":"JAMA"},{"key":"2022051715243928100_ytac189-B6","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1056\/NEJMoa071880","article-title":"Minimizing ventricular pacing to reduce atrial fibrillation in sinus-node disease","volume":"357","author":"Sweeney","year":"2007","journal-title":"N Engl J Med"},{"key":"2022051715243928100_ytac189-B7","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1111\/pace.13513","article-title":"AV hysteresis causing initiation of recurrent atrial arrhythmias","volume":"41","author":"Monkhouse","year":"2018","journal-title":"Pacing Clin Electrophysiol"},{"key":"2022051715243928100_ytac189-B8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10840-016-0177-7","article-title":"Increased risk of ventricular fibrillation associated with RYTHMIQ\u2122: lessons learned","volume":"48","author":"Nguyen","year":"2017","journal-title":"J Interv Card Electrophysiol"},{"key":"2022051715243928100_ytac189-B9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/europace\/eum290","article-title":"Long-term reliability of AAI mode pacing in patients with sinus node dysfunction and low Wenckebach block rate","volume":"10","author":"Adachi","year":"2008","journal-title":"Europace"},{"article-title":"NICE technology appraisal [TA 314]: Implantable cardioverter defibrillators and cardiac resynchronisation therapy for arrhythmias and heart failure (review of TA95 and TA120)","year":"2014","author":"National Institute of Health and Care Excellence","key":"2022051715243928100_ytac189-B10"},{"key":"2022051715243928100_ytac189-B11","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1161\/01.CIR.0000065226.24159.E9","article-title":"Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure","volume":"107","author":"St John Sutton","year":"2003","journal-title":"Circulation"},{"key":"2022051715243928100_ytac189-B12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.hrthm.2017.10.014","article-title":"Permanent His-bundle pacing as an alternative to biventricular pacing for cardiac resynchronization therapy: a multicenter experience","volume":"15","author":"Sharma","year":"2018","journal-title":"Heart Rhythm"}],"container-title":["European Heart Journal - 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