{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:48:11Z","timestamp":1772642891908,"version":"3.50.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Systemic capillary leak syndrome (SCLS) is a potentially fatal disorder characterized by relapses of hypovolemic shock episodes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case Summary<\/jats:title>\n                  <jats:p>We present a case of a 58-year-old man who presented to the Emergency Department with a history of recurrent episodes of syncope in the last hours. A few days before medical contact the patient complained of sore throat, fever, and flu-like symptoms. He was initially admitted with a diagnosis of suspected myopericarditis. Forty-eight hours later, the haemodynamic status suddenly deteriorated to a mixed cardiogenic and shock; an endomyocardial biopsy showed localized inflammatory infiltrates and areas of necrosis of cardiomyocytes with positive viral search for parvovirus B19 (PVB19), therefore the patient was treated with methylprednisolone pulses. Based on the concurrent presence of the typical triad of hypotension, hypoalbuminaemia, and haemoconcentration we suspected systemic leak capillary syndrome potentially triggered by the PVB19 infection with acute myocarditis. The clinical conditions further deteriorated with rhabdomyolysis and acute kidney injury: we started continuous veno-venous haemofiltration adding a cytokines adsorber. In the following hours, we observed a significant clinical improvement. The patient was discharged 1 month later and 5 months after discharge he experienced a new attack of SCLS, this time without myocardial involvement and with prompt symptoms resolution.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Systemic capillary leak syndrome is a potentially fatal disorder: early recognition of this entity and prompt initiation of supportive therapy are warranted, therefore, it is paramount that an emergency physician thinks of SCLS in patients with signs of cardiogenic shock and the classical triad of hypotension, hypoalbuminia, and haemoconcentration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac262","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T04:51:16Z","timestamp":1656391876000},"source":"Crossref","is-referenced-by-count":7,"title":["Systemic leak capillary syndrome with myocardial involvement 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\u2018De Gasperis\u2019 Cardio Center, ASST Grande Ospedale Metropolitano Niguarda , Milan 20126 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Sacco","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u2018De Gasperis\u2019 Cardio Center, ASST Grande Ospedale Metropolitano Niguarda , Milan 20126 , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,6,28]]},"reference":[{"key":"2022070817473390100_ytac262-B1","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1182\/blood-2011-08-375816","article-title":"Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome)","volume":"119","author":"Xie","year":"2012","journal-title":"Blood"},{"key":"2022070817473390100_ytac262-B2","first-page":"1000213","article-title":"Inflammatory markers of the systemic capillary leak syndrome (Clarkson 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