{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:31:55Z","timestamp":1780407115405,"version":"3.54.1"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Giant cell myocarditis (GCM) is a rare and rapidly progressive disease associated with significant morbidity and mortality. Whilst patients more frequently present with acute heart failure, diagnosis is difficult due to heterogeneity in clinical presentations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>This case report presents a previously healthy 59-year-old Vietnamese woman who initially presented with syncope and a motor vehicle accident who developed rapid decline in left ventricular function. Her initial echocardiogram was suggestive of an infiltrative cardiomyopathy. GCM was confirmed on biopsy, and she received combined immunosuppression. Twenty-seven days following her initial presentation to hospital, she was unable to recover from severe multi-organ dysfunction, and the patient was palliated and passed away.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This case highlights the varied manner in which GCM may present. Even in the absence of cardiogenic shock at presentation, giant cell myocarditis should be considered in the evaluation of new cardiomyopathy of uncertainty aetiology. Diagnosis of this condition has distinct clinical implications on management and prognosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac269","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T11:17:56Z","timestamp":1657538276000},"source":"Crossref","is-referenced-by-count":2,"title":["A case report of giant cell myocarditis after a syncope-related motor vehicle accident: an atypical presentation for a life-threatening condition"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0905-2531","authenticated-orcid":false,"given":"Lily A","family":"Pham","sequence":"first","affiliation":[{"name":"School of Medicine, The University of Queensland , Brisbane, QLD 4102 , Australia"},{"name":"Department of Cardiology, Princess Alexandra Hospital , Brisbane, QLD 4102 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Princess Alexandra Hospital , Brisbane, QLD 4102 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callan","family":"Gavaghan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Princess Alexandra Hospital , Brisbane, QLD 4102 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"2022071913385379200_ytac269-B1","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1056\/nejm199706263362603","article-title":"Idiopathic giant-cell myocarditis\u2013natural history and treatment. Multicenter giant cell myocarditis study group investigators","volume":"336","author":"Cooper LT","year":"1997","journal-title":"N Engl J Med"},{"key":"2022071913385379200_ytac269-B2","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/s0025-6196(12)61286-5","article-title":"Evaluation of postmortem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: implications for role of sampling error","volume":"64","author":"Hauck","year":"1989","journal-title":"Mayo Clin Proc"},{"key":"2022071913385379200_ytac269-B3","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.jacc.2020.11.074","article-title":"Management of Patients with giant cell myocarditis: JACC review topic of the week","volume":"77","author":"Bang","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"2022071913385379200_ytac269-B4","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1161\/circheartfailure.112.969261","article-title":"Diagnosis, treatment, and outcome of giant-cell myocarditis in the era of combined immunosuppression","volume":"6","author":"Kandolin","year":"2013","journal-title":"Circ Heart Fail"},{"key":"2022071913385379200_ytac269-B5","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fcvm.2019.00064","article-title":"Myocarditis in humans and in experimental animal models","volume":"6","author":"B\u0142yszczuk","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"2022071913385379200_ytac269-B6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.healun.2015.10.009","article-title":"Alemtuzumab as a novel treatment for refractory giant cell myocarditis after heart transplantation","volume":"35","author":"Evans","year":"2016","journal-title":"J Heart Lung Transplant"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytac269\/44818054\/ytac269.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/7\/ytac269\/45025197\/ytac269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/7\/ytac269\/45025197\/ytac269.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T13:39:09Z","timestamp":1658237949000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytac269\/6639670"}},"subtitle":[],"editor":[{"given":"Diego","family":"Araiza-Garaygordobil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Constantinos","family":"Bakogiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Edin","family":"Begic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Megh","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Damien Farhad Nur","family":"Salekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,1]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7,6]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytac269","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,7,1]]},"article-number":"ytac269"}}