{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:19:47Z","timestamp":1770740387843,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hyperthyroidism has a significant, well-established impact on the cardiovascular system on both a molecular and circulatory level. The cardiac consequences of thyrotoxicosis are not uncommon, indicated by a 1.2% prevalence of this disorder in the United States. However, our case describes the less widely observed association between thyrotoxicosis and valvulopathy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 69-year-old Hispanic male presented with a 3-week history of shortness of breath, intermittent chest pain, and lower extremity swelling. Transthoracic echocardiogram revealed a dilated left and right atrium with severe tricuspid regurgitation, moderate mitral regurgitation, malcoaptation of the tricuspid valve leaflets, and a myxomatous mitral valve. In addition, right ventricular systolic function was moderately reduced. A right and left heart catheterization was performed with findings of normal right heart pressures and normal coronary arteries, respectively. To further evaluate the aetiology of the patient\u2019s heart failure, thyroid studies were sent, revealing a thyroid-stimulating hormone value of &amp;lt;0.010\u2005uIU\/mL and a free T4 of 1.96\u2005ng\/dL. A 4.9\u2005cm lesion was seen on thyroid ultrasound. We concluded that the patient\u2019s heart failure and notable valvular abnormalities were likely as a result of thyrotoxic heart disease. Furosemide and methimazole were initiated while inpatient, and the patient was discharged with close follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>We demonstrate a unique case of the possible hemodynamic and cellular effects of thyroid hormone on the development of primary and secondary valve dysfunction. This association is important for clinicians to be aware of, as treatment of its underlying aetiology can lead to improvement in a patient\u2019s cardiac outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac305","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T12:55:32Z","timestamp":1662468932000},"source":"Crossref","is-referenced-by-count":3,"title":["Right heart failure in the setting of thyrotoxic valvulopathy: the pathophysiology of an often neglected diagnosis: a case report"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1934-1537","authenticated-orcid":false,"given":"Sarah","family":"Harirforoosh","sequence":"first","affiliation":[{"name":"Department of Medicine, University of California, Irvine , 101 The City Dr S, City Tower Ste 400 , Orange, CA 92868-3201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garrett","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, Irvine , 101 The City Dr S, City Tower Ste 400 , Orange, CA 92868-3201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Glovaci","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of California, Irvine , 101 the City Dr S, Orange, CA 92868, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pranav M","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of California, Irvine , 101 the City Dr S, Orange, CA 92868, 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