{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:48:59Z","timestamp":1753876139072,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Lamin A\/C (LMNA) mutations account for 5\u20138% of familial dilated cardiomyopathies, and can manifest with conduction abnormalities and ventricular arrhythmias in 78% of patients. Therefore, when suspected, it is important to implant the correct type of device.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 52-year-old gentleman with a family history of cardiomyopathy, presented with asymptomatic atrial fibrillation and complete atrioventricular block associated with a narrow QRS interval. Investigations confirmed dilated and severely impaired left ventricular systolic function. He underwent successful conduction system pacing in combination with a primary prevention defibrillator. Genetic screening confirmed LMNA cardiomyopathy. During 3 years follow up, his left ventricular function remained unchanged with stable conduction system capture and he received appropriate therapy from his device for ventricular tachycardia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>His-bundle pacing promotes rapid and synchronous activation of the ventricles via the intrinsic conduction system of the heart. In selected individuals with LMNA cardiomyopathy, conduction system pacing is viable alternative to conventional cardiac resynchronization therapy using coronary sinus tributaries.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac324","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T12:02:42Z","timestamp":1659441762000},"source":"Crossref","is-referenced-by-count":1,"title":["A case report of successful physiological pacing in a patient with lamin A\/C cardiomyopathy"],"prefix":"10.1093","volume":"6","author":[{"given":"Nitin","family":"Chandra Mohan","sequence":"first","affiliation":[{"name":"Cardiology, The Great Western Hospitals NHS Trust , Marlborough Road, Swindon SN3 6BB , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Foley","sequence":"additional","affiliation":[{"name":"Cardiology, The Great Western Hospitals NHS Trust , Marlborough Road, Swindon SN3 6BB , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-0501","authenticated-orcid":false,"given":"Badrinathan","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Cardiology, The Great Western Hospitals NHS Trust , Marlborough Road, Swindon SN3 6BB , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"2022083013194618800_ytac324-B1","first-page":"e7761","article-title":"Lamin A\/C cardiomyopathy with E203K pathogenic mutation","volume":"12","author":"Sheikh","year":"2020","journal-title":"Cureus"},{"key":"2022083013194618800_ytac324-B2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jacc.2011.08.078","article-title":"Risk factors for malignant ventricular arrhythmias in lamin A\/C mutation carriers a European cohort study","volume":"59","author":"van Rijsingen","year":"2012","journal-title":"J Am Coll 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