{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T19:58:33Z","timestamp":1787687913265,"version":"build-2784847793"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"crossref","award":["1194521N"],"award-info":[{"award-number":["1194521N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Severe aortic valve stenosis (AS) is the most frequent valve pathology in the developed world requiring intervention. Due to common factors in pathogenesis, patients with AS frequently have concomitant coronary artery disease (CAD). Determining the relative contribution of each component to the disease state is not easy as there is much overlap in complaints. Moreover, severe AS interferes with the haemodynamic assessment of intermediate coronary lesions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>In this case report we describe the presentation and management of an 84-year-old patient, with a severely degenerated aortic valve bioprosthesis and an intermediate coronary artery lesion, presenting with acute decompensated heart failure and chest pain. Initial invasive haemodynamic assessment of the coronary lesion provided challenging findings and a second catheterization and intervention was needed to free the patient from his chest pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Optimal assessment and treatment of CAD before valve replacement are controversial. Aortic valve stenosis on itself can lead to subendocardial ischaemia with subsequent angina pectoris. Simultaneously, AS can significantly affect coronary haemodynamics, hereby interfering with intra-coronary haemodynamic assessment of co-existing coronary lesions. Currently used coronary physiological indices are not validated in the AS population and valve replacement has variable effects on the fractional flow reserve and commonly used resting indices, such as the resting full-cycle ratio. Further research on this topic is needed and an overview of currently running studies that will advance this field significantly is provided.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac333","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T22:15:26Z","timestamp":1660169726000},"source":"Crossref","is-referenced-by-count":10,"title":["Coronary physiology to guide treatment of coronary artery disease in a patient with severe aortic valve stenosis: friend or foe? A case report"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-6320","authenticated-orcid":false,"given":"Lennert","family":"Minten","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, Katholieke Universiteit Leuven , Herestraat 49, 3000 Leuven , Belgium"},{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven (UZ Leuven) , 3000 Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3265-1620","authenticated-orcid":false,"given":"Keir","family":"McCutcheon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Katholieke Universiteit Leuven , Herestraat 49, 3000 Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8301-4517","authenticated-orcid":false,"given":"Johan","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Katholieke Universiteit Leuven , Herestraat 49, 3000 Leuven , Belgium"},{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven (UZ Leuven) , 3000 Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Dubois","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Katholieke Universiteit Leuven , Herestraat 49, 3000 Leuven , Belgium"},{"name":"Department of Cardiovascular Medicine, University Hospitals Leuven (UZ Leuven) , 3000 Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"2022082217374549900_ytac333-B1","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.jacc.2015.03.034","article-title":"Perioperative results and complications in 15,964 transcatheter aortic valve replacements: prospective data from the GARY registry","volume":"65","author":"Walther","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2022082217374549900_ytac333-B2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease: developed by the task force for the management of valvular heart disease of the European society of cardiology (ESC) and the European association for cardio-thoracic surgery (EACTS)","volume":"43","author":"Vahanian","year":"2021","journal-title":"Eur Heart J"},{"key":"2022082217374549900_ytac333-B3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41569-018-0011-2","article-title":"Pathophysiological coronary and microcirculatory flow alterations in aortic stenosis","volume":"15","author":"Michail","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"2022082217374549900_ytac333-B4","doi-asserted-by":"crossref","first-page":"e006979","DOI":"10.1161\/CIRCHEARTFAILURE.120.006979","article-title":"Cardiac microvascular endothelial cells in pressure overload-induced heart disease","volume":"14","author":"Trenson","year":"2021","journal-title":"Circ Heart Fail"},{"key":"2022082217374549900_ytac333-B5","doi-asserted-by":"crossref","first-page":"e002356","DOI":"10.1161\/CIRCINTERVENTIONS.114.002356","article-title":"Transcatheter replacement of stenotic aortic valve normalizes cardiac-coronary interaction by restoration of systolic coronary flow dynamics as assessed by wave intensity analysis","volume":"9","author":"Rolandi","year":"2016","journal-title":"Circ Cardiovasc Interv"},{"key":"2022082217374549900_ytac333-B6","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jacc.2016.05.071","article-title":"Coronary physiology during exercise and vasodilation in the healthy heart and in severe aortic stenosis","volume":"68","author":"Lumley","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2022082217374549900_ytac333-B7","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jacc.2016.05.070","article-title":"Ischemia in aortic stenosis: new insights and potential clinical relevance","volume":"68","author":"Gould","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2022082217374549900_ytac333-B8","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.jcin.2018.07.019","article-title":"Coronary hemodynamics in patients with severe aortic stenosis and coronary artery disease undergoing transcatheter aortic valve replacement: implications for clinical indices of coronary stenosis severity","volume":"11","author":"Ahmad","year":"2018","journal-title":"JACC Cardiovasc Interv"},{"key":"2022082217374549900_ytac333-B9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4244\/EIJ-D-17-00719","article-title":"Left ventricular afterload reduction by transcatheter aortic valve implantation in severe aortic stenosis and its prompt effects on comprehensive coronary haemodynamics","volume":"14","author":"Stoller","year":"2018","journal-title":"EuroIntervention"},{"key":"2022082217374549900_ytac333-B10","doi-asserted-by":"crossref","first-page":"e011331","DOI":"10.1161\/CIRCINTERVENTIONS.121.011331","article-title":"Long-term changes in invasive physiological pressure indices of stenosis severity following transcatheter aortic valve implantation","volume":"15","author":"Sabbah","year":"2022","journal-title":"Circ Cardiovasc Interv"},{"key":"2022082217374549900_ytac333-B11","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.jcin.2021.06.041","article-title":"ACTIVATION (Percutaneous coronary inTervention prIor to transcatheter aortic VAlve implantaTION): a randomized clinical trial","volume":"14","author":"Patterson","year":"2021","journal-title":"JACC Cardiovasc Interv"},{"key":"2022082217374549900_ytac333-B12","doi-asserted-by":"crossref","first-page":"e012618","DOI":"10.1161\/JAHA.119.012618","article-title":"Physiological versus angiographic guidance for myocardial revascularization in patients undergoing transcatheter aortic valve implantation","volume":"8","author":"Lunardi","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2022082217374549900_ytac333-B13","doi-asserted-by":"crossref","first-page":"H1106","DOI":"10.1152\/ajpheart.00541.2021","article-title":"The coronary and microcirculatory measurements in patients with aortic valve stenosis study: rationale and design","volume":"321","author":"Minten","year":"2021","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytac333\/45318440\/ytac333.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/8\/ytac333\/45496008\/ytac333.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/8\/ytac333\/45496008\/ytac333.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T17:38:07Z","timestamp":1661189887000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytac333\/6659951"}},"subtitle":[],"editor":[{"given":"Michel","family":"Corban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Rafail","family":"Kotronias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Doralisa","family":"Morrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Parham","family":"Eshtehardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Brett Sydney","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Fabienne","family":"Vervaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8,4]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytac333","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,1]]},"published":{"date-parts":[[2022,8,1]]},"article-number":"ytac333"}}