{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T17:15:56Z","timestamp":1794244556093,"version":"4.9.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patients with a bicuspid aortic valve have increased risk of infective endocarditis, but common organisms are not always the culprit. We describe a case of an otherwise healthy young gentleman with bicuspid aortic valve who experienced Abiotrophia defectiva endocarditis. The aim of this case report is to highlight an uncommon cause of endocarditis associated with significant morbidity and mortality in order to improve the care provided by trainees and clinicians.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 37-year-old male presented with a 1-month history of fever, weight loss, myalgia, and night sweats. On transoesophageal echocardiography, he was found to have a bicuspid aortic valve with large vegetation and severe aortic insufficiency. Blood cultures were positive for A. defectiva. The endocarditis was successfully treated with surgical aortic valve replacement and 6 weeks of antibiotic therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Bicuspid valves are known to have increased susceptibility to endocarditis. The difficulty of isolating A. defectiva typically leads to delayed diagnosis and significant complications. This case is a reminder to have a high degree of suspicion for organisms which are rare and difficult to isolate because prompt recognition and surgical intervention may improve the outcome of care.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac394","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T19:41:46Z","timestamp":1663962106000},"source":"Crossref","is-referenced-by-count":2,"title":["<i>Abiotrophia defectiva<\/i> endocarditis of bicuspid aortic valve: a case report"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9069-2906","authenticated-orcid":false,"given":"Sadaf","family":"Fakhra","sequence":"first","affiliation":[{"name":"Kirk Kerkorian School of Medicine at UNLV , 2040 W. Charleston Blvd., 3rd Floor, Las Vegas, NV, 89102 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awad","family":"Javaid","sequence":"additional","affiliation":[{"name":"Kirk Kerkorian School of Medicine at UNLV , 2040 W. Charleston Blvd., 3rd Floor, Las Vegas, NV, 89102 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaan","family":"Shafi","sequence":"additional","affiliation":[{"name":"Kirk Kerkorian School of Medicine at UNLV , 2040 W. Charleston Blvd., 3rd Floor, Las Vegas, NV, 89102 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chowdhury","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Kirk Kerkorian School of Medicine at UNLV , 2040 W. Charleston Blvd., 3rd Floor, Las Vegas, NV, 89102 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"2022101010564804300_ytac394-B1","doi-asserted-by":"crossref","first-page":"openhrt","DOI":"10.1136\/openhrt-2016-000545","article-title":"Risk and outcomes of aortic valve endocarditis among patients with bicuspid and tricuspid aortic valves","volume":"4","author":"Kiyota","year":"2017","journal-title":"Open Heart"},{"key":"2022101010564804300_ytac394-B2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3949\/ccjm.85a.17069","article-title":"Bicuspid aortic valve: basics and beyond","volume":"85","author":"Shah","year":"2018","journal-title":"Cleve Clin J Med"},{"key":"2022101010564804300_ytac394-B3","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1128\/AAC.02645-15","article-title":"Antimicrobial susceptibilities of Abiotrophia defectiva, Granulicatella adiacens, and Granulicatella elegans","volume":"60","author":"Alberti","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2022101010564804300_ytac394-B4","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/00365540600606424","article-title":"Abiotrophia defectiva: a rare cause of infective endocarditis","volume":"38","author":"Yemisen","year":"2006","journal-title":"Scand J Infect Dis"},{"key":"2022101010564804300_ytac394-B5","first-page":"5186520","article-title":"Rare but not infrequent: infective endocarditis caused by Abiotrophia defectiva","volume":"2018","author":"Chowdhury","year":"2018","journal-title":"Case Rep Infect Dis"},{"key":"2022101010564804300_ytac394-B6","first-page":"1242","article-title":"Abiotrophia defectiva: an unusual cause of endocarditis","volume":"12","author":"Baroz","year":"2016","journal-title":"Rev Med Suisse"},{"key":"2022101010564804300_ytac394-B7"},{"key":"2022101010564804300_ytac394-B8","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2014-207361","article-title":"Abiotrophia defectiva endocarditis","volume":"2014","author":"Pinkney","year":"2014","journal-title":"BMJ Case Rep"},{"key":"2022101010564804300_ytac394-B9","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/icvts\/ivx278","article-title":"Ecomment. Abiotrofia defectiva\u2014a fastidious bacterial species that warrants optimal co-operation between the clinic and the laboratory","volume":"25","author":"Mestrovic","year":"2017","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"2022101010564804300_ytac394-B10","first-page":"5038563","article-title":"Granulicatella adiacens and Abiotrophia defectiva native vertebral osteomyelitis: three cases and literature review of clinical characteristics and treatment approach","volume":"2019","author":"Puzzolante","year":"2019","journal-title":"Case Rep Infect Dis"},{"key":"2022101010564804300_ytac394-B11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/00365540410016104","article-title":"Brain abscesses caused by Abiotrophia defectiva: complication of immunosuppressive therapy in a patient with connective-tissue disease","volume":"36","author":"Zenone","year":"2004","journal-title":"Scand J Infect Dis"},{"key":"2022101010564804300_ytac394-B12"},{"key":"2022101010564804300_ytac394-B13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s15010-021-01690-x","article-title":"16S rDNA PCR for the aetiological diagnosis of culture-negative infective endocarditis","volume":"50","author":"Anton-Vazquez","year":"2022","journal-title":"Infection"},{"key":"2022101010564804300_ytac394-B14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.12691\/ajmcr-8-9-15","article-title":"Significant PR prolongation and new onset left bundle branch block in aortic root abscess: a marker of disease progression and poor prognosis","volume":"8","author":"Kariyanna","year":"2020","journal-title":"Am J Med Case Rep"},{"key":"2022101010564804300_ytac394-B15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.7861\/clinmed.cme.20.1.1","article-title":"Infective endocarditis: a contemporary update","volume":"20","author":"Rajani","year":"2020","journal-title":"Clin Med"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytac394\/45985763\/ytac394.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/10\/ytac394\/46403989\/ytac394.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/6\/10\/ytac394\/46403989\/ytac394.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T10:57:17Z","timestamp":1665399437000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytac394\/6712674"}},"subtitle":[],"editor":[{"given":"Piotr Nikodem","family":"Rudz\u00ednski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Marcelo Haertel","family":"Miglioranza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Jan","family":"Henzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Oliver Ian","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]},{"given":"Tinka Julia","family":"van Trier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,23]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10,8]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytac394","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,10,1]]},"published":{"date-parts":[[2022,9,23]]},"article-number":"ytac394"}}