{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:23Z","timestamp":1753876223200,"version":"3.41.2"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T00:00:00Z","timestamp":1665705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Malignant tumours of the aortic valve apparatus are extremely rare and difficult to diagnose. Their proximity to the coronary ostium may cause an acute coronary syndrome (ACS) either by infiltration or by embolization.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We report a case of primary aortic valve undifferentiated sarcoma causing recurrent episodes of ACS, and we provide a literature review for primary cardiac valve tumours. This case also highlights the need for further evaluation of other causes of ACS in patients with minimal coronary artery disease risk factors and recurrent ACS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The majority of valve tumours are fibroelastomas. Sarcomas are rare and lead to poor outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac412","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T06:56:35Z","timestamp":1665730595000},"source":"Crossref","is-referenced-by-count":0,"title":["Recurrent acute coronary syndrome caused by a primary aortic valve sarcoma: grand rounds and literature review"],"prefix":"10.1093","volume":"6","author":[{"given":"Martine","family":"Parent","sequence":"first","affiliation":[{"name":"Cardiovascular Division, McGill University Health Center Montreal , Montreal, QC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Lachapelle","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Division, McGill University Health Center Montreal , Montreal, QC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badia","family":"Issa-Chergui","sequence":"additional","affiliation":[{"name":"Department of Pathology, McGill University Health Center Montreal , Montreal, QC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Alcindor","sequence":"additional","affiliation":[{"name":"Oncology Division, McGill University Health Center Montreal , Montreal, QC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2248-9663","authenticated-orcid":false,"given":"Jacques","family":"Genest","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, McGill University Health Center Montreal , Montreal, QC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negareh","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, McGill University Health Center Montreal , Montreal, QC , Canada"},{"name":"Cardio-Oncology Program, McGill University Health Center Montreal , Montreal, QC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"2024051617561203800_ytac412-B1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.mayocp.2019.05.001","article-title":"Acute myocardial infarction in young individuals","volume":"95","author":"Gulati","year":"2020","journal-title":"Mayo Clin Proc"},{"key":"2024051617561203800_ytac412-B2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jacc.2018.05.026","article-title":"Neoplasia and the heart: pathological review of effects with clinical and radiological correlation","volume":"72","author":"Maleszewski","year":"2018","journal-title":"J Am Coll Cardiol"},{"journal-title":"J Thorac Cardiovasc Surg","article-title":"Primary cardiac sarcomas: treatment strategies","author":"Chan","key":"2024051617561203800_ytac412-B3"},{"key":"2024051617561203800_ytac412-B4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1510\/icvts.2004.103044","article-title":"Surgical experience with 77 primary cardiac tumors","volume":"4","author":"Bossert","year":"2005","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"2024051617561203800_ytac412-B5","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0003-4975(91)91293-5","article-title":"Primary cardiac valve tumors","volume":"52","author":"Edwards","year":"1991","journal-title":"Ann Thorac Surg"},{"key":"2024051617561203800_ytac412-B6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13019-016-0406-2","article-title":"Surgical treatment of primary cardiac valve tumor: early and late results in eight patients","volume":"11","author":"Wang","year":"2016","journal-title":"J Cardiothorac Surg"},{"key":"2024051617561203800_ytac412-B7","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8539606","article-title":"Infiltrating cardiac synovial sarcoma presenting as acute cerebrovascular accident","volume":"2017","author":"Okoro","year":"2017","journal-title":"Case Rep Med"},{"key":"2024051617561203800_ytac412-B8","first-page":"348","article-title":"Primary undifferentiated sarcoma of the mitral and aortic valves","volume":"17","author":"Ramos","year":"2008","journal-title":"J Heart Valve Dis"},{"key":"2024051617561203800_ytac412-B9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.carpath.2006.12.006","article-title":"Low-grade myofibroblastic sarcoma of the heart causing sudden death","volume":"17","author":"Eisenstat","year":"2008","journal-title":"Cardiovasc Pathol"}],"container-title":["European Heart Journal - 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