{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:48:18Z","timestamp":1776872898474,"version":"3.51.2"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Due to the increasing prevalence of Kawasaki Disease (KD) in adulthood, the number of women considering pregnancy is growing. There are limited data on the course of pregnancy in KD with coronary artery involvement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We report on the pregnancy outcome of a 30-year-old woman with KD who was successfully resuscitated for ventricular tachycardia 3 years before. At that time, bypass surgery and later implantable cardioverter-defibrillator implantation were performed because of thrombotically occluded calcified giant coronary aneurysms. The pregnancy course was initially uncomplicated, however, at 31 weeks of gestation, left-sided breast cancer was diagnosed. Weighing maximum therapeutic efficacy against acceptable foetal and maternal cardiotoxic risk, our multidisciplinary team decided on neoadjuvant chemotherapy. The mother and foetus tolerated the therapy well. However, at 36 weeks of gestation, due to HELLP (haemolysis, elevated liver, low platelets) syndrome, a caesarean section had to be performed. The newborn was healthy with good APGAR (appearance, pulse, grimace, activity, respiration) scores. Three weeks after delivery, chemotherapy was restarted and at Week 4 after the caesarean section, the tumour was no more detectable.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>We discuss data on pregnancy and KD and outline that pregnancy can be considered if the clinical condition is good and left ventricular function is preserved. We also address possible therapeutic approaches and care for breast cancer in pregnancy and coexisting cardiovascular disease. The extraordinary importance of interdisciplinary cooperation between different disciplines in such complex clinical disease conditions is emphasized.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac435","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T13:28:36Z","timestamp":1667654916000},"source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy and breast cancer in a patient with complicated Kawasaki Disease, as if one problem was not enough: a case report"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-2159","authenticated-orcid":false,"given":"Gina","family":"Barzen","sequence":"first","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charit\u00e9-Universit\u00e4tsmedizin Berlin , Charit\u00e9platz 1, Campus Mitte, D-10117 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Stangl","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charit\u00e9-Universit\u00e4tsmedizin Berlin , Charit\u00e9platz 1, Campus Mitte, D-10117 Berlin , Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) , partner side Berlin, Augustenburger Platz 1, D-13353 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-250X","authenticated-orcid":false,"given":"Jens-Uwe","family":"Blohmer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gyn\u00e4kologie und Brustzentrum, Charit\u00e9- Universit\u00e4tsmedizin Berlin , Charit\u00e9platz 1, Campus Mitte, D-10117 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0759-832X","authenticated-orcid":false,"given":"Wolfgang","family":"Henrich","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Geburtsmedizin, Charit\u00e9- Universit\u00e4tsmedizin , Charit\u00e9platz 1, Campus Mitte, Campus Virchow-Klinikum, D-10117 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6478-7725","authenticated-orcid":false,"given":"Thomas","family":"D\u00f6rner","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charit\u00e9-Universit\u00e4tsmedizin Berlin , Charit\u00e9platz 1, Campus Mitte, D-10117 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Lembcke","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Radiologie, Charit\u00e9-Universit\u00e4tsmedizin Berlin , Charit\u00e9platz 1, Campus Mitte, D-10117 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7356-6281","authenticated-orcid":false,"given":"Verena","family":"Stangl","sequence":"additional","affiliation":[{"name":"Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie, Charit\u00e9-Universit\u00e4tsmedizin Berlin , Charit\u00e9platz 1, Campus Mitte, D-10117 Berlin , Germany"},{"name":"DZHK (German Centre for Cardiovascular Research) , partner side Berlin, Augustenburger Platz 1, D-13353 Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"2024051617523019600_ytac435-B1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/heartjnl-2019-315925","article-title":"Kawasaki disease writing group, on behalf of the royal college of paediatrics and child health, and the British cardiovascular society. 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