{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:25:47Z","timestamp":1758126347067,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Coronavirus disease 2019 (COVID-19) mRNA vaccine\u2013associated acute myocarditis has been well described, and the demonstration of elevated high-sensitivity cardiac troponin (hs-cTn) is crucial for its diagnosis. However, falsely elevated hs-cTn can occasionally occur, leading to incorrect diagnosis. Here, we report the case of a patient who was given an erroneous diagnosis of COVID-19 mRNA vaccine\u2013associated acute myocarditis due to falsely elevated hs-cTn, likely from assay interference.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 29-year-old Chinese male presented with 3 months of chest pain, dyspnoea, and palpitations starting a few days after his second dose of mRNA-1273 (Moderna) vaccine. High-sensitivity cardiac troponin I was elevated at presentation, which rose further 4\u2005h later. The provisional diagnosis was acute myocarditis after a computed tomography coronary angiogram showed normal coronaries. Cardiac magnetic resonance was also negative for myocardial inflammation. The hs-cTn I levels fluctuated but remained elevated on outpatient serial testing, despite no new symptoms or clinical events. A paired serum sample showed elevated hs-cTn I but normal hs-cTn T, confirming a diagnosis of false-positive hs-cTn I. Further investigations, including blood tests before and after a subsequent uneventful mRNA-1273 booster vaccination, were performed to investigate for assay interference.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Widespread COVID-19 mRNA vaccination has resulted in an awareness of vaccine-related acute myocarditis and a more thorough evaluation of post-vaccination cardiac symptoms. Although false-positive hs-cTn rarely occurs, extensive testing will inevitably result in a significant number of patients with falsely elevated hs-cTn. Clinicians should exclude this possibility and consider using alternative hs-cTn assay when investigation results and clinical presentation appear discordant.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac448","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T05:50:25Z","timestamp":1669096225000},"source":"Crossref","is-referenced-by-count":1,"title":["Erroneous diagnosis of COVID-19 mRNA vaccine\u2013associated acute myocarditis due to false-positive high-sensitive troponin I assay: a case report"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2727-1436","authenticated-orcid":false,"given":"Vivian Goh Yi","family":"Suan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tan Tock Seng Hospital , 11 Jln Tan Tock Seng, Singapore 308433 , Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Tan Tock Seng Hospital , Singapore , Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Sen","family":"Yew","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tan Tock Seng Hospital , 11 Jln Tan Tock Seng, Singapore 308433 , Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"2022121316264192500_ytac448-B1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1161\/CIRCULATIONAHA.121.056135","article-title":"Myocarditis with COVID-19 mRNA 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