{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:19:28Z","timestamp":1756383568622,"version":"3.41.2"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In the USA, \u223c300 000 people are affected by Chagas heart disease, a growing, but commonly overlooked, public health issue. Chagas as a potential aetiology of dilated cardiomyopathy remains under-recognized. We present a case where multimodality imaging was essential in the diagnosis and management of Chagas heart disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 54-year-old man, originally from Mexico, presented to the emergency department with chest pain and recurrent syncopal episodes, found to be in haemodynamically unstable ventricular tachycardia (VT) requiring urgent cardioversion. Urgent coronary angiography revealed no obstructive disease. A transthoracic echocardiogram revealed moderately reduced left ventricular systolic function (left ventricular ejection fraction 35\u201340%) with apical akinesis and an aneurysm of the apical septum. Cardiac magnetic resonance (CMR) confirmed a prominent apical aneurysm with dyskinesis of the apical septum, with the evidence of transmural myocardial late gadolinium enhancement of the entire left ventricular apex and a small apical thrombus. Serologic testing was positive for Trypanosoma cruzi IgG antibody, which was confirmed on repeat testing at the Centers for Disease Control and Prevention. Patient underwent VT ablation and was discharged on guideline-directed medical therapy including a regimen of anticoagulation, beta-blocker, and angiotensin-converting enzyme inhibitor therapies. He has had no subsequent syncope or VT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Chagas heart disease remains under-recognized and under-diagnosed despite the growing burden of T. cruzi infection in the USA. Suspicion for Chagas heart disease should be considered in patients presenting with heart failure symptoms and ventricular arrhythmias with the right corresponding history and imaging findings on echocardiogram and CMR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytac487","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T04:57:51Z","timestamp":1673153871000},"source":"Crossref","is-referenced-by-count":1,"title":["Case report: diagnosis of chronic Chagas cardiomyopathy using a multimodality imaging approach"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7191-4852","authenticated-orcid":false,"given":"Shannon X","family":"Li","sequence":"first","affiliation":[{"name":"Division of Cardiology, Rush University Medical Center , 1717 West Congress Parkway, Chicago, IL 60612 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estefania Oliveros","family":"Soles","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Temple University Hospital , 3401 N Broad St, Philadelphia, PA 19140 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parikshit S","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Rush University Medical Center , 1717 West Congress Parkway, Chicago, IL 60612 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupama K","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Rush University Medical Center , 1717 West Congress Parkway, Chicago, IL 60612 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"2023011115362202200_ytac487-B1","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1161\/CIR.0000000000000599","article-title":"Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association","volume":"138","author":"Nunes","year":"2018","journal-title":"Circulation"},{"key":"2023011115362202200_ytac487-B2","first-page":"33","article-title":"Chagas disease in Latin America: an epidemiological update based on 2010 estimates","volume":"90","author":"WHO Geneva","year":"2015","journal-title":"Relev Epidemiol Hebd"},{"key":"2023011115362202200_ytac487-B3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.actatropica.2009.07.019","article-title":"Chagas disease in Spain, the United States and other non-endemic countries","volume":"115","author":"Gascon","year":"2010","journal-title":"Acta Trop"},{"key":"2023011115362202200_ytac487-B4","article-title":"Chagas cardiomyopathy","volume":"14","author":"Mora","year":"2016","journal-title":"E-Journal Cardiol 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patients with the acute phase or indeterminate form of Chagas disease","volume":"31","author":"Acquatella","year":"2018","journal-title":"J Am Soc Echocardiogr"},{"key":"2023011115362202200_ytac487-B9","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/ehjci\/jex154","article-title":"Multimodality imaging evaluation of Chagas disease: an expert consensus of Brazilian Cardiovascular Imaging Department (DIC) and the European Association of Cardiovascular Imaging (EACVI)","volume":"19","author":"Nunes","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2023011115362202200_ytac487-B10","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart 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