{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:50:35Z","timestamp":1771494635618,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Light-chain deposition disease (LCDD) is a systemic disorder characterized by non-amyloidotic light-chain deposition in various organs with Bence-Jones type monoclonal gammopathy. Although known as monoclonal gammopathy of renal significance, it may involve interstitial tissue of various organs, and in rare cases, proceeds to organ failure. We present a case of cardiac LCDD in a patient initially suspected of dialysis-associated cardiomyopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>A 65-year-old man with end-stage renal disease requiring haemodialysis presented with fatigue, anorexia, and shortness of breath. He had a history of recurrent congestive heart failure and Bence-Jones type monoclonal gammopathy. A cardiac biopsy performed for suspected light-chain cardiac amyloidosis was negative for diagnostic Congo-red stain, however, paraffin immunofluorescence examination for light-chain suggested diagnosis of cardiac LCDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Cardiac LCDD may go undetected leading to heart failure due to lack of clinical awareness and insufficient pathological investigation. In heart failure cases with Bence-Jones type monoclonal gammopathy, clinicians should consider not only amyloidosis but also interstitial light-chain deposition. In addition, in patients with chronic kidney disease of unknown cause, investigation is recommended to rule out cardiac light-chain deposition disease concomitant with renal LCDD. Although LCDD is relatively rare it occasionally affects multiple organs; therefore, it would be better to describe it as a monoclonal gammopathy of clinical significance rather than one of renal significance.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ehjcr\/ytad049","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T14:53:42Z","timestamp":1676300022000},"source":"Crossref","is-referenced-by-count":6,"title":["Cardiac light-chain deposition disease and hints at diagnosing: a case report"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8654-7311","authenticated-orcid":false,"given":"Ryo","family":"Nishioka","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Kanazawa University Hospital , 13-1, Takara-machi, Kanazawa, Ishikawa 920-8641 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kanazawa University Hospital , 13-1, Takara-machi, Kanazawa, Ishikawa 920-8641 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Department of Haematology, Kanazawa University Hospital , 13-1, Takara-machi, Kanazawa, Ishikawa 920-8641 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-2116","authenticated-orcid":false,"given":"Mitsuhiro","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kanazawa University Hospital , 13-1, Takara-machi, Kanazawa, Ishikawa 920-8641 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"2023030116313183300_","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000007030","article-title":"Infiltrative nonamyloidotic monoclonal immunoglobulin light chain cardiomyopathy: an underappreciated manifestation of plasma cell dyscrasias","volume":"93","author":"Buxbaum","year":"2000","journal-title":"Cardiology"},{"key":"2023030116313183300_","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0165-2478(94)90036-1","article-title":"Overrepresentation of the V kappa IV subgroup in light chain deposition disease","volume":"42","author":"Denoroy","year":"1994","journal-title":"Immunol Lett"},{"key":"2023030116313183300_","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1172\/JCI115252","article-title":"Structure of a monoclonal kappa chain of the V kappa IV subgroup in the kidney and plasma cells in light chain deposition disease","volume":"87","author":"Cogn\u00e9","year":"1991","journal-title":"J Clin Invest"},{"key":"2023030116313183300_","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1053\/j.ajkd.2003.08.040","article-title":"Light chain deposition disease with renal involvement: clinical characteristics and prognostic factors","volume":"42","author":"Pozzi","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"2023030116313183300_","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3346\/jkms.2009.24.2.354","article-title":"A case of cardiac dysfunction associated with monoclonal gammopathy of undetermined significance","volume":"24","author":"Jang","year":"2009","journal-title":"J Korean Med Sci"},{"key":"2023030116313183300_","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12968-016-0308-4","article-title":"Cardiac T1 mapping and extracellular volume (ECV) in clinical practice: a comprehensive review","volume":"18","author":"Haaf","year":"2016","journal-title":"J Cardiavasc Megn Reson"},{"key":"2023030116313183300_","doi-asserted-by":"crossref","first-page":"552","DOI":"10.5858\/arpa.2020-0018-OA","article-title":"Paraffin immunofluorescence increase light-chain detection in extra-renal light chain amyloidosis and other light-chain associated diseases","volume":"145","author":"Gibier","year":"2021","journal-title":"Arch Pathol Lab Med"},{"key":"2023030116313183300_","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0025-6196(11)62336-7","article-title":"Reversible restrictive cardiomyopathy due to light-chain deposition disease","volume":"77","author":"Nakamura","year":"2002","journal-title":"Mayo Clin Proc"},{"key":"2023030116313183300_","doi-asserted-by":"crossref","first-page":"173","DOI":"10.12659\/AJCR.895762","article-title":"A case of cardiac light chain deposition disease in a patient with solitary plasmacytoma","volume":"17","author":"Mohan","year":"2016","journal-title":"Am J Case Rep"},{"key":"2023030116313183300_","doi-asserted-by":"crossref","first-page":"e160","DOI":"10.1093\/ehjci\/jeab126","article-title":"Nonamyloidotic light chain deposition cardiomyopathy","volume":"22","author":"Haaf","year":"2021","journal-title":"Eur Heart J Cardiovasc Imaging"}],"container-title":["European Heart Journal - 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