{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:26:42Z","timestamp":1788791202180,"version":"build-2803163510"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fetal supraventricular tachycardia (SVT) is the most common fetal tachyarrhythmia and can cause fetal heart failure and intrauterine death. The management varies within institution and usually based on published case series, institutional experience.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case summary<\/jats:title><jats:p>Fetal SVT with hydrops (ascites and subcutaneous edema) was diagnosed at 26 weeks of gestational age. The first direct injection of fetal amiodarone into the umbilical vein resulted in temporary cardioversion to the sinus rhythm and mild transient maternal adverse event. The second direct fetal amiodarone to the fetal peritoneal cavity resulted in conversion to sinus rhythm, resolution of fetal hydrops, and normal fetal growth until delivery at 39 weeks gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Treatment of fetal SVT often requires prolonged maternal antiarrhythmic treatment and carries a significant risk of maternal adverse events. Direct fetal antiarrhythmic treatment often requires achieving adequate therapeutic drugs, especially in hydropic fetus. Amiodarone is one of drugs options for fetal SVT with hydrops because it has been shown to be highly effective with low fetal mortality. Continuous vital sign and ECG monitoring should be performed during direct fetal antiarrhythmic administration.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ehjcr\/ytad128","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T15:32:46Z","timestamp":1679585566000},"source":"Crossref","is-referenced-by-count":4,"title":["Multiple direct fetal amiodarone administration for supraventricular tachycardia with hydrops fetalis: a case report"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8851-6455","authenticated-orcid":false,"given":"Irvan","family":"Adenin","sequence":"first","affiliation":[{"name":"National Center for Maternal and Children Health\u2014Harapan Kita Maternal & Children Hospital , Let Jen S Parman 87, Jakarta 11420 , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8232-7020","authenticated-orcid":false,"given":"Rachmat Dediat","family":"Kapnosa Hasani","sequence":"additional","affiliation":[{"name":"National Center for Maternal and Children Health\u2014Harapan Kita Maternal & Children Hospital , Let Jen S Parman 87, Jakarta 11420 , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"2023041111473721800_","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1159\/000519911","article-title":"Management of fetal supraventricular tachycardia: case series from a tertiary perinatal cardiac center","volume":"48","author":"Broom","year":"2021","journal-title":"Fetal Diagn Ther"},{"key":"2023041111473721800_","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-3-319-77461-9_11","volume-title":"Fetal cardiology: A practical approach to diagnosis and management","author":"Vigneswaran","year":"2018"},{"key":"2023041111473721800_","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/jce.14406","article-title":"Low mortality in fetal supraventricular tachycardia: outcomes in a 30-year single-institution experience","volume":"31","author":"O\u2019Leary","year":"2020","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2023041111473721800_","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1017\/S104795111400002X","article-title":"Foetal supraventricular tachycardia with hydrops fetalis: a role for direct intraperitoneal amiodarone","volume":"25","author":"Kang","year":"2015","journal-title":"Cardiol Young"},{"key":"2023041111473721800_","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1159\/000508811","article-title":"Refractory fetal supraventricular tachycardia with hydrops successfully converted by intraperitoneal flecainide in the Fetus: A case report","volume":"47","author":"Vedel","year":"2020","journal-title":"Fetal Diagn Ther"},{"key":"2023041111473721800_","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.3390\/jcm10112510","article-title":"Treatment of fetal arrhythmias","volume":"10","author":"Veduta","year":"2021","journal-title":"J Clin Med"},{"key":"2023041111473721800_","first-page":"171","volume-title":"Fetal therapy: scientific basis and critical appraisal of clinical benefits","author":"Jaeggi","year":"2013"},{"key":"2023041111473721800_","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1161\/01.CIR.0000109494.05317.58","article-title":"Amiodarone therapy for drug-refractory fetal tachycardia","volume":"109","author":"Strasburger","year":"2004","journal-title":"Circulation"},{"key":"2023041111473721800_","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1046\/j.1469-0705.1991.01030162.x","article-title":"Fetal tachyarrhythmias: transplacental and direct treatment of the Fetus\u2014A report of 60 cases","volume":"1","author":"Hansmann","year":"1991","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2023041111473721800_","doi-asserted-by":"crossref","DOI":"10.1186\/s13052-020-0785-9","article-title":"Fetal arrhythmias: prenatal evaluation and intrauterine therapeutics","volume":"46","author":"Yuan","year":"2020","journal-title":"Ital J Pediatr"},{"key":"2023041111473721800_","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/uog.21980","article-title":"Cordocentesis-associated fetal loss and risk factors: single-center experience with 6650 cases","volume":"56","author":"Tanvisut","year":"2020","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2023041111473721800_","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1177\/1753495X18808118","article-title":"Maternal monitoring and safety considerations during antiarrhythmic treatment for fetal supraventricular tachycardia","volume":"12","author":"Malham\u00e9","year":"2019","journal-title":"Obstet Med"}],"container-title":["European Heart Journal - 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