{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:11:06Z","timestamp":1790835066750,"version":"4.1.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015797","name":"Austrian Society of Cardiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Unicentric Castleman\u2019s disease (UCD), a lymphoproliferative disorder characterized by enlargement of the lymph nodes, is a rare cause of Amyloid-A amyloidosis. While patients usually present with impaired kidney function and proteinuria, heart involvement is neither common nor the main cause of signs and symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present a patient who was admitted to the hospital for impaired exercise capacity. Diagnostic work-up revealed severe left ventricular hypertrophy suggestive of cardiac amyloidosis. Although Congo red staining of endomyocardial biopsies was initially negative, subsequent immunohistochemical staining against serum amyloid A finally confirmed the diagnosis of cardiac amyloidosis. 18F-fluorodeoxyglucose positron emission tomography\/computed tomography revealed a tumour located in dorsal of the duodenum. Fine-needle aspiration biopsy of the tumour was suggestive but could not confirm the presence of UCD beyond reasonable doubt. Rapid worsening of heart failure symptoms warranted urgent surgical tumourectomy, which resulted in immediate post-operative lowering of serum amyloid protein. However, post-operative cardiogenic shock could not be stabilized even with veno-arterial extracorporeal membrane oxygenation, and the patient eventually died. The UCD of the hyaline vascular (HV) subtype was confirmed by pathologic work-up of the excised tumour.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This case report presents for the first time a patient with malignant cardiac Amyloid-A amyloidosis caused by unicentric Castleman\u2019s disease of the HV subtype. Since the disease progresses swiftly, rapid diagnosis is essential for potential curative treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytad451","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T07:08:18Z","timestamp":1694416098000},"source":"Crossref","is-referenced-by-count":1,"title":["Unicentric Castleman\u2019s disease associated with malignant cardiac Amyloid-A amyloidosis: a case report"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9211-8345","authenticated-orcid":false,"given":"Thomas","family":"Schuetz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III\u2014Cardiology and Angiology, Medical University Innsbruck , Anichstrasse 35, 6020 Innsbruck , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Schiller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, Elisabethinen Hospital , Seilerst\u00e4tte 4, 4010 Linz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0203-2498","authenticated-orcid":false,"given":"Karin","family":"Klingel","sequence":"additional","affiliation":[{"name":"Cardiopathology Department, Institute for Pathology and Neuropathology, T\u00fcbingen University Hospital , Liebermeisterstr. 8, 72076 T\u00fcbingen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gattermeier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Landesklinikum Waidhofen\/Ybbs , Ybbsitzerstra\u00dfe 112, 3340 Waidhofen an der Ybbs , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2588-6739","authenticated-orcid":false,"given":"Gerhard","family":"Poelzl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III\u2014Cardiology and Angiology, Medical University Innsbruck , Anichstrasse 35, 6020 Innsbruck , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"2023091408414855400_ytad451-B1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/bjh.15019","article-title":"The full spectrum of Castleman disease: 273 patients studied over 20 years","volume":"180","author":"Oksenhendler","year":"2018","journal-title":"Br J Haematol"},{"key":"2023091408414855400_ytad451-B2","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1056\/NEJMoa070265","article-title":"Natural history and outcome in systemic AA amyloidosis","volume":"356","author":"Lachmann","year":"2007","journal-title":"N Engl J Med"},{"key":"2023091408414855400_ytad451-B3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/oxfordjournals.eurheartj.a060225","article-title":"Amyloid cardiomyopathy in systemic non-hereditary amyloidosis. 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