{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T21:57:19Z","timestamp":1776463039040,"version":"3.51.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Interatrial block (IAB) is a conduction delay in Bachmann\u2019s bundle with a well-described association with structural heart disease, supraventricular arrhythmias, and cardiovascular events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We report the case of an asymptomatic 35-year-old man in whom the presence of IAB at electrocardiogram led to a comprehensive evaluation including speckle-tracking echocardiography, 24\u2005h Holter monitoring, and genetic testing. Speckle-tracking echocardiography demonstrated a decrease in the longitudinal strain of interventricular septum, a typical feature of LMNA-related cardiomyopathy, and decreased indices of left atrial deformation. A diagnosis of cardiac laminopathy related to the frame shift variant c.1367 (p.Asn456Thrfs*24) of the LMNA gene was made. A dual-chamber implantable cardioverter defibrillator implantation was performed for the high risk of life-threatening ventricular tachyarrhythmias.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This case demonstrates that IAB could be a rare presentation of a life-threatening laminopathy. Strain echocardiography is an essential tool to evaluate the deposition of fibrosis tissue in subclinical cardiomyopathies. Our report describes a novel variant of LMNA gene associated with a high risk of sudden cardiac death.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytad532","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T19:02:35Z","timestamp":1698433355000},"source":"Crossref","is-referenced-by-count":4,"title":["Interatrial block as a first clinical presentation of atrial cardiomyopathy related to a novel LMNA variant: a case report"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4298-6165","authenticated-orcid":false,"given":"Michele","family":"Iavarone","sequence":"first","affiliation":[{"name":"Cardiology Unit, Department of Translational Medical Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, AORN Ospedali dei Colli Monaldi Hospital , Via L. Bianchi 1 c\/o Monaldi Hospital, AORN Colli , Naples 80131, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Covino","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Translational Medical Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, AORN Ospedali dei Colli Monaldi Hospital , Via L. Bianchi 1 c\/o Monaldi Hospital, AORN Colli , Naples 80131, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Petillo","sequence":"additional","affiliation":[{"name":"Medical and Laboratory Genetics Unit , A.O.R.N. \u2018Antonio Cardarelli\u2019 , Naples 80131, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-0360","authenticated-orcid":false,"given":"Vincenzo","family":"Russo","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Translational Medical Sciences, University of Campania \u2018Luigi Vanvitelli\u2019, AORN Ospedali dei Colli Monaldi Hospital , Via L. 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