{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:04:40Z","timestamp":1774343080180,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>COVID-19 infection and the COVID-19 vaccines have been associated with rare cases of pericarditis. We present a case of constrictive pericarditis (CP) following the vaccine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 19-year-old healthy male started having progressive abdominal pain, emesis, dyspnoea, and pleuritic chest pain 2 weeks after the second dose of Pfizer vaccine. Computed tomography angiography chest revealed bilateral pleural effusions and pericardial thickening with effusion. Cardiac catheterization showed ventricular interdependence. Cardiac magnetic resonance (CMR) showed septal bounce and left ventricular tethering suggestive of CP. A total pericardiectomy was performed with significant symptom improvement. Pathology showed chronic fibrosis without amyloid, iron deposits, or opportunistic infections. Patient had Epstein\u2013Barr Virus (EBV) viraemia 825\u2005IU\/mL and histoplasmosis complement-fixation positive with negative serum and urine antigen. Hypercoagulable panel and infectious workup were otherwise negative. The patient had resolution of cardiac symptoms at 3 months of follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>The patient developed progressive symptoms within 2 weeks of his second Pfizer vaccine. Echocardiogram and CMR had classic signs of CP, and pericardial pathology confirmed fibrotic pericardium. The patient had no prior surgery, thoracic radiation, or bacterial infection. Epstein\u2013Barr Virus viraemia was thought to be reactionary, and histoplasmosis complement likely represented chronic exposure. The timing of symptoms and negative multidisciplinary workup raises the suspicion for COVID vaccine\u2013induced CP. The COVID vaccines benefits far exceed the risks, but complications still can occur. Practitioners should have a high index of suspicion to allow prompt diagnosis of CP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytad540","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T12:10:16Z","timestamp":1699531816000},"source":"Crossref","is-referenced-by-count":5,"title":["A case report of constrictive pericarditis following COVID-19 vaccination"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4950-0241","authenticated-orcid":false,"given":"Eric","family":"Bain","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Indiana University School of Medicine , 635 Barnhill Drive, Van Nuys Medical Science Building 116, Indianapolis, IN 46202 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5746-3135","authenticated-orcid":false,"given":"Maya","family":"Guglin","sequence":"additional","affiliation":[{"name":"Krannert Institute of Cardiology, Indiana University School of Medicine , Indianapolis, IN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"2023113020495556000_ytad540-B1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.11604\/pamj.2021.38.141.22884","article-title":"Constrictive pericarditis: 21 years\u2019 experience and review of literature","volume":"38","author":"Karima","year":"2021","journal-title":"Pan Afr Med J"},{"key":"2023113020495556000_ytad540-B2","volume-title":"Constrictive Pericarditis","author":"Yadav","year":"2022"},{"key":"2023113020495556000_ytad540-B3","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/S0140-6736(22)00791-7","article-title":"Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA: a cohort study in claims databases","volume":"399","author":"Wong","year":"2022","journal-title":"Lancet"},{"key":"2023113020495556000_ytad540-B4","doi-asserted-by":"crossref","first-page":"e069445","DOI":"10.1136\/bmj-2021-069445","article-title":"Incidence, risk factors, natural history, and hypothesized mechanisms of myocarditis and pericarditis following covid-19 vaccination: living evidence syntheses and review","volume":"378","author":"Pillay","year":"2022","journal-title":"BMJ"},{"key":"2023113020495556000_ytad540-B5","doi-asserted-by":"crossref","first-page":"e2218505","DOI":"10.1001\/jamanetworkopen.2022.18505","article-title":"Epidemiology of myocarditis and pericarditis following mRNA vaccination by vaccine product, schedule, and interdose interval among adolescents and adults in Ontario","volume":"5","author":"Buchan","year":"2022","journal-title":"Canada. JAMA Netw Open"},{"key":"2023113020495556000_ytad540-B6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijid.2022.01.027","article-title":"Constrictive pericarditis after SARS-CoV-2 vaccination: a case report","volume":"116","author":"Nakanishi","year":"2022","journal-title":"Int J Infect Dis"},{"key":"2023113020495556000_ytad540-B7","doi-asserted-by":"crossref","first-page":"ytac012","DOI":"10.1093\/ehjcr\/ytac012","article-title":"Effusive-constrictive pericarditis after the second dose of BNT162b2 vaccine (Comirnaty): a case report","volume":"6","author":"Viani","year":"2022","journal-title":"Eur Heart J Case Rep"},{"key":"2023113020495556000_ytad540-B8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jccase.2022.03.014","article-title":"Constrictive pericarditis following mRNA COVID-19 vaccination in a patient with systemic sclerosis","volume":"26","author":"Misumi","year":"2022","journal-title":"J Cardiol Cases"},{"key":"2023113020495556000_ytad540-B9","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.radcr.2022.07.021","article-title":"Constrictive pericarditis following inactivated virus COVID-19 vaccine: a case report with review of the literature","volume":"17","author":"Hajsadeghi","year":"2022","journal-title":"Radiol Case Rep"},{"key":"2023113020495556000_ytad540-B10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jccase.2022.07.006","article-title":"A case of transient constrictive pericarditis after COVID-19","volume":"26","author":"Talerico","year":"2022","journal-title":"J Cardiol Cases"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytad540\/52967058\/ytad540.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/7\/11\/ytad540\/53520567\/ytad540.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/7\/11\/ytad540\/53520567\/ytad540.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T20:51:09Z","timestamp":1701377469000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytad540\/7375502"}},"subtitle":[],"editor":[{"given":"Clement","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Matthew","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Deborah","family":"Cosmi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Franca","family":"Morselli","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":10,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytad540","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11]]},"published":{"date-parts":[[2023,11]]},"article-number":"ytad540"}}