{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:39:11Z","timestamp":1777693151500,"version":"3.51.4"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Percutaneous alcohol septal ablation (ASA) is a non-surgical treatment for symptomatic hypertrophic obstructive cardiomyopathy. It has a potential risk for systolic anterior motion (SAM)\u2013related mitral regurgitation (MR) deterioration, leading to acute congestive heart failure. In such clinical scenarios, additional surgical interventions for SAM-MR are risky.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 70-year-old man experienced acutely deteriorated heart failure caused by SAM-related MR following ASA, for which venous-arterial extracorporeal membrane oxygenation (ECMO) and a percutaneous left ventricular assist device (Impella CP, Abiomed, MA, USA) were required. Transoesophageal echocardiography showed that an interventricular septal oedematous protrusion led to a large coaptation gap of mitral leaflets with a pseudo-prolapse of the posterior mitral leaflet (PML). Because of his prohibitive surgical risks, we opted for transcatheter edge-to-edge mitral valve repair with MitraClip therapy. After removing the Impella device, an XT clip (Abbott Vascular, CA, USA) was located to cover the pseudo-prolapsed PML, resulting in optimal MR reduction with an acceptable mean transmitral valve-pressure gradient. Thereafter, his heart failure was well controlled, and venous-arterial ECMO was successfully removed on post-MitraClip Day 2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>This case demonstrated that MitraClip therapy rescued the patient from a rare complication of severe acute heart failure with haemodynamic collapse caused by massive SAM-related MR following ASA. MitraClip therapy can be a feasible, less-invasive interventional therapy for SAM-related MR in cases with acceptable severity of iatrogenic mitral stenosis post-MitraClip implantation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytad599","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T07:05:04Z","timestamp":1700895904000},"source":"Crossref","is-referenced-by-count":2,"title":["Bailout MitraClip therapy for deteriorated systolic anterior motion\u2013related severe mitral regurgitation post-alcohol septal ablation: a case report"],"prefix":"10.1093","volume":"7","author":[{"given":"Shinsuke","family":"Nakano","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Hyogo Prefectural Harima-Himeji General Medical Center , 3-264 Kamiya-cho , Himeji 670-8560, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5268-4606","authenticated-orcid":false,"given":"Hiroyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Hyogo Prefectural Harima-Himeji General Medical Center , 3-264 Kamiya-cho , Himeji 670-8560, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Hyogo Prefectural Harima-Himeji General Medical Center , 3-264 Kamiya-cho , Himeji 670-8560, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-8072","authenticated-orcid":false,"given":"Tomofumi","family":"Takaya","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Hyogo Prefectural Harima-Himeji General Medical Center , 3-264 Kamiya-cho , Himeji 670-8560, Japan"},{"name":"Department of Exploratory and Advanced Search in Cardiology, Kobe University Graduate School of Medicine , Kobe , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"2024030519561206600_ytad599-B1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jjcc.2021.11.023","article-title":"Percutaneous transluminal septal myocardial ablation: past, present, and future","volume":"80","author":"Maekawa","year":"2022","journal-title":"J Cardiol"},{"key":"2024030519561206600_ytad599-B2","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1253\/circj.CJ-18-0575","article-title":"Contemporary septal reduction therapy in drug-refractory hypertrophic obstructive cardiomyopathy","volume":"82","author":"Maekawa","year":"2018","journal-title":"Circ J"},{"key":"2024030519561206600_ytad599-B3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jcmg.2018.11.006","article-title":"Proportionate and disproportionate functional mitral regurgitation: a new conceptual framework that reconciles the results of the MITRA-FR and COAPT trials","volume":"12","author":"Grayburn","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"2024030519561206600_ytad599-B4","first-page":"71","article-title":"MitraClip therapy for mitral regurgitation: primary mitral regurgitation","volume":"5","author":"Athappan","year":"2016","journal-title":"Interv Cardiol Clin"},{"key":"2024030519561206600_ytad599-B5","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.jaccas.2020.07.007","article-title":"SAM and severe mitral regurgitation post-acute type A aortic dissection surgery treated with MitraClip","volume":"2","author":"Tagliari","year":"2020","journal-title":"JACC Case Rep"},{"key":"2024030519561206600_ytad599-B6","article-title":"MitraClip therapy for acutely developed systolic anterior motion-related severe mitral regurgitation after mitral annuloplasty","volume":"6","author":"Tsunamoto","year":"2022","journal-title":"Eur Heart J Case Rep"},{"key":"2024030519561206600_ytad599-B7","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jchf.2015.06.011","article-title":"A systematic review and meta-analysis of long-term outcomes after septal reduction therapy in patients with hypertrophic cardiomyopathy","volume":"3","author":"Liebregts","year":"2015","journal-title":"JACC Heart Fail"},{"key":"2024030519561206600_ytad599-B8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11886-021-01553-9","article-title":"Complications following MitraClip implantation","volume":"23","author":"Schnitzler","year":"2021","journal-title":"Curr Cardiol Rep"}],"container-title":["European Heart Journal - 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