{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:48:42Z","timestamp":1753876122527,"version":"3.41.2"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:00:00Z","timestamp":1705708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Tumour necrosis factor (TNF)-alpha inhibition is a core therapeutic avenue for a broad range of inflammatory and autoimmune disorders including rheumatoid arthritis and inflammatory bowel disease, as well as dermatological conditions such as hidradenitis suppurativa. Adalimumab has become one of the most common TNF-alpha\u2013inhibiting agents, which is used for many of these conditions. Treatment with such agents is associated with numerous systemic side effects, though cardiac complications remain relatively rare. These include reports of pericarditis and pericardial effusions1\u20133.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 63-year-old lady was referred to the outpatient respiratory clinic with a 1-year history of increasing breathlessness, on a background of 4 years of treatment with adalimumab for Stage III hidradenitis suppurativa. A high-resolution computed tomography (CT) thorax revealed evidence of pericardial calcification. Subsequent left and right heart catheterization study revealed equalization of intraventricular pressures, consistent with constrictive pericarditis. A QuantiFERON test was negative, and rheumatological serology was unremarkable. The patient was initially managed conservatively with close follow-up, before undergoing surgical pericardectomy when she developed signs of cardiac failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Adalimumab is associated with a range of systemic side effects, though cardiac complications are relatively rare. This case highlights a potentially novel complication associated with prolonged adalimumab therapy. Given that there are reports in the literature of pericarditis and pericardial effusions associated with TNF-alpha inhibition1\u20133, it is reasonable to hypothesize that the calcific constrictive pericarditis seen in this case may demonstrate a novel cardiac phenomenon associated with this therapy, given the lack of any traditional aetiological factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae027","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T01:35:21Z","timestamp":1705800921000},"source":"Crossref","is-referenced-by-count":1,"title":["Calcific constrictive pericarditis following tumour necrosis factor-alpha inhibition"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2671-7803","authenticated-orcid":false,"given":"Brian","family":"Cunneen","sequence":"first","affiliation":[{"name":"Cardiology Department, Beaumont Hospital , Beaumont Road , Dublin 9, Republic of Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafiz","family":"Hussein","sequence":"additional","affiliation":[{"name":"Cardiology Department, Beaumont Hospital , Beaumont Road , Dublin 9, Republic of Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"Cardiology Department, Beaumont Hospital , Beaumont Road , Dublin 9, Republic of Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Yearoo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Beaumont Hospital , Beaumont Road , Dublin 9, Republic of Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,20]]},"reference":[{"key":"2024022909573113400_ytae027-B1","first-page":"985914","article-title":"A rare side effect due to TNF-alpha blocking agent: acute pleuropericarditis with adalimumab","volume":"2013","author":"Ozkan","year":"2013","journal-title":"Case Rep Rheumatol"},{"key":"2024022909573113400_ytae027-B2","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1016\/j.jccase.2012.08.007","article-title":"A case of effusive-constrictive pericarditis accompanying rheumatoid arthritis: the possibility of adverse effect of TNF-inhibitor therapy","volume":"7","author":"Nakamura","year":"2012","journal-title":"J Cardiol Cases"},{"key":"2024022909573113400_ytae027-B3","first-page":"9989729","article-title":"Antitumor necrosis factor-alpha (TNF-\u03b1) infliximab-induced pleural effusion and pericarditis in Crohn\u2019s disease","volume":"2021","author":"Fonseca","year":"2021","journal-title":"Case Rep Pediatr"},{"key":"2024022909573113400_ytae027-B4","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1093\/eurheartj\/ehv318","article-title":"2015 ESC guidelines for the diagnosis and management of pericardial diseases: the task force for the diagnosis and management of pericardial diseases of the European Society of Cardiology (ESC)","volume":"36","author":"Adler","year":"2015","journal-title":"Eur Heart J"},{"key":"2024022909573113400_ytae027-B5","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1016\/j.jacc.2005.03.050","article-title":"The efficacy of brain natriuretic peptide levels in differentiating constrictive pericarditis from restrictive cardiomyopathy","volume":"45","author":"Leya","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"2024022909573113400_ytae027-B6","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1093\/ejcts\/ezt138","article-title":"Constrictive pericarditis: risks, aetiologies and outcomes after total pericardiectomy: 24 years of experience","volume":"44","author":"Szab\u00f3","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"key":"2024022909573113400_ytae027-B7","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.jacc.2003.11.048","article-title":"Constrictive pericarditis: etiology and cause-specific survival after pericardiectomy","volume":"43","author":"Bertog","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2024022909573113400_ytae027-B8","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1161\/01.CIR.100.13.1380","article-title":"Constrictive pericarditis in the modern era: evolving clinical spectrum and impact on outcome after pericardiectomy","volume":"100","author":"Ling","year":"1999","journal-title":"Circulation"},{"key":"2024022909573113400_ytae027-B9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.14503\/THIJ-16-5772","article-title":"Surgical treatment of constrictive pericarditis","volume":"44","author":"Depboylu","year":"2017","journal-title":"Tex Heart Inst J"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytae027\/56295814\/ytae027.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/2\/ytae027\/56657147\/ytae027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/2\/ytae027\/56657147\/ytae027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T09:57:47Z","timestamp":1709200667000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytae027\/7582932"}},"subtitle":[],"editor":[{"given":"Clement","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Gautam","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Nidhish","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Franca","family":"Morselli","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1,20]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytae027","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2024,1,20]]},"article-number":"ytae027"}}