{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:48:55Z","timestamp":1753876135439,"version":"3.41.2"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Sodium azide exposures are rare but can be lethal as the substance inhibits complex IV in the electron transport chain, blocking adenosine-triphosphate (ATP) synthesis. Sodium azide is mostly used as a propellant in vehicular airbags but is also used in laboratory, pharmacy, and industrial settings. No known antidote exists and its cardiotoxic effects are poorly described in the literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We describe the case of a 31-year-old patient with major depressive disorder presenting with altered mental status after ingestion of an unknown amount of sodium azide. Although initially chest pain free, she developed pleuritic chest pain 48\u2005h after ingestion. This was accompanied by new diffuse ST elevations on the electrocardiogram and serum troponin elevations concerning for myopericarditis. Treatment was pursued with a 14-day course of colchicine resulting in complete symptom resolution within 4 days of treatment initiation. The patient\u2019s transthoracic echocardiogram was only notable for a preserved left ventricular ejection fraction (LVEF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Cardiac toxicity after sodium azide ingestion usually occurs days after ingestion and has been previously described in the forms of heart failure with reduced ejection fraction complicated by cardiogenic shock. We describe the first case of sodium azide-induced myopericarditis with a preserved LVEF treated with colchicine. Colchicine is an established treatment for pericarditis, but its inhibition of endocytosis, an ATP-dependent cellular function, could be mechanistically relevant to this case.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae134","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T12:46:57Z","timestamp":1710852417000},"source":"Crossref","is-referenced-by-count":1,"title":["A case report of sodium azide-induced myopericarditis"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7563-2430","authenticated-orcid":false,"given":"Constantine","family":"Tarabanis","sequence":"first","affiliation":[{"name":"Leon H. Charney Division of Cardiology, New York University Langone Health, New York University Grossman School of Medicine , 550 1st Avenue, New York, NY 10016 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darcy","family":"Banco","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, New York University Langone Health, New York University Grossman School of Medicine , 550 1st Avenue, New York, NY 10016 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma M","family":"Keller","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, New York University Langone Health, New York University Grossman School of Medicine , 550 1st Avenue, New York, NY 10016 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sripal","family":"Bangalore","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, New York University Langone Health, New York University Grossman School of Medicine , 550 1st Avenue, New York, NY 10016 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos L","family":"Alviar","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, New York University Langone Health, New York University Grossman School of Medicine , 550 1st Avenue, New York, NY 10016 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"2024043014052661000_ytae134-B1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1080\/15563650.2021.1906888","article-title":"Sodium azide poisoning: a narrative review","volume":"59","author":"Tat","year":"2021","journal-title":"Clin Toxicol"},{"key":"2024043014052661000_ytae134-B2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.52964\/AMJA.0903","article-title":"Potential therapies for sodium azide intoxication; a case report and review of the literature","volume":"21","author":"Groeneveld","year":"2022","journal-title":"Acute Med J"},{"key":"2024043014052661000_ytae134-B3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.17987\/icfj.v4i0.151","article-title":"Surviving a massive sodium azide poisoning with toxic cardiomyopathy","volume":"4","author":"Overtchouk","year":"2015","journal-title":"Int Cardiovasc Forum J"},{"key":"2024043014052661000_ytae134-B4","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0021-9258(19)52746-6","article-title":"The in vitro inhibition of cytochrome oxidase by azide and cyanide","volume":"172","author":"Stannard","year":"1948","journal-title":"J Biol Chem"},{"key":"2024043014052661000_ytae134-B5","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/134933b0","article-title":"Inhibitors of catalase reaction","volume":"134","author":"Keilin","year":"1934","journal-title":"Nature"},{"key":"2024043014052661000_ytae134-B6","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1021\/acs.chemrestox.9b00422","article-title":"A comparison of potential azide antidotes in a mouse model","volume":"33","author":"Frawley","year":"2020","journal-title":"Chem Res Toxicol"},{"key":"2024043014052661000_ytae134-B7","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/0002-9149(89)90781-9","article-title":"Fatal azide-induced cardiomyopathy presenting as acute myocardial infarction","volume":"64","author":"Judge","year":"1989","journal-title":"Am J Cardiol"},{"key":"2024043014052661000_ytae134-B8","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1080\/15563650701665001","article-title":"A case of survival following high-dose sodium azide poisoning","volume":"45","author":"Watanabe","year":"2007","journal-title":"Clin Toxicol (Phila)"},{"key":"2024043014052661000_ytae134-B9","doi-asserted-by":"publisher","DOI":"10.1177\/2048872620910109","article-title":"Update on myocarditis\u2014what we know so far and where we may be heading","volume":"10","author":"Rroku","year":"2020","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"2024043014052661000_ytae134-B10","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1021\/mp700089s","article-title":"Endocytosis inhibitors prevent poly(amidoamine) dendrimer internalization and permeability across caco-2 cells","volume":"5","author":"Kitchens","year":"2008","journal-title":"Mol Pharm"}],"container-title":["European Heart Journal - 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