{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:00:23Z","timestamp":1776952823208,"version":"3.51.4"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Tricuspid regurgitation (TR) is associated with increased morbidity and mortality. As many elderly TR patients are deemed inoperable, transcatheter edge-to-edge repair (T-TEER) is arising as a viable treatment option. Though procedural safety aspects seem excellent, long-term risks cannot be ignored, including the feasibility of cardiac pacing by endovascular lead implantation at a later time, as well as T-TEER device-related infective endocarditis (IE), in the context of systemic infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present the case of an 80-year-old man with recurrent admissions for right heart failure due to massive TR, despite successful percutaneous mitral valve repair. The patient was turned down for surgery and eventually underwent T-TEER, with successful TR reduction to mild-to-moderate and improvement in quality of life. Five months later, the patient was admitted for symptomatic bradycardia and the first reported pacemaker implantation after T-TEER with a specific tricuspid valve device was performed. Lead implantation was guided by transoesophageal echocardiography, and did not worsen residual TR. Two years later, the patient presented with device-related tricuspid valve IE, again a \u2018first\u2019 following T-TEER. Despite antimicrobial therapy, the vegetation embolized through the atrial septal defect caused by prior mitral-TEER and triggered an ischaemic stroke. Furthermore, sepsis led to multiorgan failure and eventually death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Tricuspid regurgitation is an individual predictor of morbidity and mortality, frequently found in elderly, and should be addressed in symptomatic inoperable patients. With the rise of interventional treatment, new challenges face long-term follow-up and treatment after percutaneous repair. This case report underscores the feasibility of endovascular pacemaker lead implantation after T-TEER, while it points to the risk of device-related tricuspid valve IE.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae181","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T04:50:03Z","timestamp":1713329403000},"source":"Crossref","is-referenced-by-count":1,"title":["Two \u2018firsts\u2019 in a patient with tricuspid valve infective endocarditis following edge-to-edge repair: a case report"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0687-1926","authenticated-orcid":false,"given":"Alexandru","family":"Patrascu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Helios Hospital Pforzheim , Kanzlerstrasse 2-6, Pforzheim 75175 , Germany"},{"name":"Private University in the Principality of Liechtenstein (UFL) , Triesen , Principality of Liechtenstein"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donat","family":"Binder","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helios Hospital Pforzheim , Kanzlerstrasse 2-6, Pforzheim 75175 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feraas","family":"Al Farwan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helios Hospital Pforzheim , Kanzlerstrasse 2-6, Pforzheim 75175 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Weinmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helios Hospital Pforzheim , Kanzlerstrasse 2-6, Pforzheim 75175 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilka","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helios Hospital Pforzheim , Kanzlerstrasse 2-6, Pforzheim 75175 , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"2024043013452959100_ytae181-B1","first-page":"e1","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"23","author":"Vahanian","year":"2022","journal-title":"G Ital Cardiol (Rome)"},{"key":"2024043013452959100_ytae181-B2","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/S0140-6736(19)32600-5","article-title":"Transcatheter edge-to-edge repair for reduction of tricuspid regurgitation: 6-month outcomes of the TRILUMINATE single-arm study","volume":"394","author":"Nickenig","year":"2019","journal-title":"Lancet"},{"key":"2024043013452959100_ytae181-B3","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1056\/NEJMoa2300525","article-title":"Transcatheter repair for patients with tricuspid regurgitation","volume":"388","author":"Sorraja","year":"2023","journal-title":"N Engl J Med"},{"key":"2024043013452959100_ytae181-B4","doi-asserted-by":"crossref","first-page":"101781","DOI":"10.1016\/j.jaccas.2023.101781","article-title":"Tailored treatment of patients with intracardiac leads and tricuspid regurgitation","volume":"12","author":"Sanchis","year":"2023","journal-title":"JACC Case Rep"},{"key":"2024043013452959100_ytae181-B5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/ccd.30751","article-title":"Infective endocarditis after transcatheter edge-to-edge repair for severe mitral regurgitation; a case report and a systematic review","volume":"102","author":"Yokoyama","year":"2023","journal-title":"Catheter Cardiovasc Interv"},{"key":"2024043013452959100_ytae181-B6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.21037\/acs.2017.03.09","article-title":"Tricuspid valve endocarditis","volume":"6","author":"Hussain","year":"2017","journal-title":"Ann Cardiothorac Surg"},{"key":"2024043013452959100_ytae181-B7","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1093\/ehjci\/jex139","article-title":"The need for a new tricuspid regurgitation grading scheme","volume":"18","author":"Hahn","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2024043013452959100_ytae181-B8","author":"Patrascu"},{"key":"2024043013452959100_ytae181-B9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.hrcr.2021.11.015","article-title":"First case of pacemaker implantation in a patient with previous percutaneous edge-to-edge tricuspid valve repair","volume":"8","author":"Vitali","year":"2021","journal-title":"HeartRhythm Case Rep"},{"key":"2024043013452959100_ytae181-B10","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/europace\/euaa047","article-title":"Implantation of leadless pacemaker through neo-orifice after tricuspid valve edge-to-edge repair","volume":"22","author":"Adukauskaite","year":"2020","journal-title":"Europace"},{"key":"2024043013452959100_ytae181-B11","doi-asserted-by":"crossref","first-page":"e017293","DOI":"10.1161\/JAHA.120.017293","article-title":"Right-sided infective endocarditis 2020: challenges and updates in diagnosis and treatment","volume":"9","author":"Shmueli","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"2024043013452959100_ytae181-B12","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.1038\/s41598-020-64220-z","article-title":"Clinical prognosis of right-sided infective endocarditis not associated with cardiac devices or intravenous drug use: a cohort study and meta-analysis","volume":"10","author":"Rigau","year":"2020","journal-title":"Sci Rep"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytae181\/57245897\/ytae181.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/4\/ytae181\/57360962\/ytae181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/4\/ytae181\/57360962\/ytae181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T13:46:24Z","timestamp":1714484784000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytae181\/7646886"}},"subtitle":[],"editor":[{"given":"Gavin","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Sebastian Ekkehard","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Andriana","family":"Anagnostopoulou","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Aref Bin","family":"Abdulhak","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Abdelsalam","family":"Bensaaud","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,3,28]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytae181","relation":{},"ISSN":["2514-2119"],"issn-type":[{"value":"2514-2119","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4]]},"published":{"date-parts":[[2024,3,28]]},"article-number":"ytae181"}}