{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:50:20Z","timestamp":1753876220434,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Nail\u2013Patella syndrome (NPS) is an autosomal-dominant pleiotropic condition characterized by pelvic and skeletal abnormalities and most commonly affecting a tetrad of nails, knees, elbows, and iliac horns, the iliac horns being pathognomonic for the condition. The most well-documented extra-skeletal manifestation is renal involvement with alteration in Type III collagen. No documented cases of NPS with anomalous coronary arteries or aneurysms, acute coronary occlusion, or successfully coronary interventions exist in the medical literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 62-year-old female with a medical history significant for NPS diagnosed 50 years ago presented to the emergency department with a chief complaint of chest pain. She recently developed end-stage renal disease managed with peritoneal dialysis within the last year. Angiography revealed 100% right coronary artery occlusion with an anomalous take-off from the left circumflex artery. She demonstrated diffuse coronary aneurysms in the right coronary artery, mid-left anterior descending artery, and other epicardial vessels. Two drug-eluting stents were placed in overlapping fashion. Following careful apposition, the aneurysmal segment was successfully stented without complication. The patient was discharged without complication 2 days later.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Our case shows the first reported case of coronary vascular anomalies and successful coronary revascularization in a patient with NPS in the medical literature. Given the recently reported vascular anomalies and known collagen alterations seen in patients with the genetic disorder, clinicians should suspect further systemic vascular anomalies with their own unique therapeutic challenges when encountering patients with this rare genetic syndrome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae188","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T21:44:10Z","timestamp":1713476650000},"source":"Crossref","is-referenced-by-count":0,"title":["ST-segment elevation myocardial infarction in Nail\u2013Patella syndrome with anomalous coronary anatomy and aneurysms: a case report"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3121-2722","authenticated-orcid":false,"given":"Kyle","family":"Varkoly","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, McLaren Macomb Hospital , 1000 Harrington St, Mount Clemens, MI 48043 , 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Blair","family":"DeYoung","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Ascension Macomb Medical Center , 11800 Twelve Mile Rd, Warren, MI 48093 , USA"},{"name":"Department of Cardiovascular Medicine, McLaren Macomb Hospital , 1030 Harrington St, Mt Clemens, MI 48043 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"2024050611364440300_ytae188-B1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/jmg.40.3.153","article-title":"Nail Patella syndrome: a review of the phenotype aided by developmental biology","volume":"40","author":"Sweeney","year":"2003","journal-title":"J Med Genet"},{"key":"2024050611364440300_ytae188-B2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.gene.2019.05.003","article-title":"Type III collagen (COL3A1): gene and 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