{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:37:48Z","timestamp":1771328268718,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Hypersensitivity reactions to iodinated contrast media (ICM) are frequently encountered in clinical practice. Severe manifestations, despite being infrequent, can be life-threatening and represent an issue when re-administration of ICM is required. Clear recommendations on prevention and management of relapses are still lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present the cases of two patients presenting with acute coronary syndrome requiring urgent coronary angiography, with an anamnesis of ICM-induced drug reaction with eosinophilia and systemic symptoms syndrome. Both patients safely underwent a coronary angiography with the use of a different ICM (iobitridol) to the one linked to hypersensitivity manifestations, after premedication with corticosteroids and H1 antagonists.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Our experience highlights that in clinical situations in which the use of ICM is urgently needed, premedication with corticosteroids and H1 antagonists together with the choice of an alternative contrast agent (when the culprit is known) represents an effective strategy to perform a potentially life-saving procedure while avoiding serious systemic allergic reactions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae259","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T16:21:55Z","timestamp":1716308515000},"source":"Crossref","is-referenced-by-count":2,"title":["Management of acute coronary syndromes requiring coronary angiography in patients with drug reaction with eosinophilia and systemic symptoms syndrome induced by iodinated contrast media: two case reports and narrative review"],"prefix":"10.1093","volume":"8","author":[{"given":"Carola","family":"Griffith Brookles","sequence":"first","affiliation":[{"name":"Cardiology Division, San Luigi Gonzaga University Hospital , Regione Gonzole 10, 10043 Orbassano, Turin , Italy"},{"name":"Department of Medical Sciences, University of Turin , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-6437","authenticated-orcid":false,"given":"Matteo","family":"Bianco","sequence":"additional","affiliation":[{"name":"Cardiology Division, San Luigi Gonzaga University Hospital , Regione Gonzole 10, 10043 Orbassano, Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Pizzimenti","sequence":"additional","affiliation":[{"name":"Severe Asthma and Rare Lung Disease Unit, San Luigi Gonzaga University Hospital , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Gobello","sequence":"additional","affiliation":[{"name":"Cardiology Division, San Luigi Gonzaga University Hospital , Regione Gonzole 10, 10043 Orbassano, Turin , Italy"},{"name":"Department of Medical Sciences, University of Turin , Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carloalberto","family":"Biol\u00e8","sequence":"additional","affiliation":[{"name":"Cardiology Division, San Luigi Gonzaga University Hospital , Regione Gonzole 10, 10043 Orbassano, Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Destefanis","sequence":"additional","affiliation":[{"name":"Cardiology Division, San Luigi Gonzaga University Hospital , Regione Gonzole 10, 10043 Orbassano, Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-7534","authenticated-orcid":false,"given":"Enrico","family":"Cerrato","sequence":"additional","affiliation":[{"name":"Cardiology Division, San Luigi Gonzaga University Hospital , Regione Gonzole 10, 10043 Orbassano, Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Chinaglia","sequence":"additional","affiliation":[{"name":"Cardiology Division, San Luigi Gonzaga University Hospital , Regione Gonzole 10, 10043 Orbassano, Turin , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"2024062814422388400_ytae259-B1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.18176\/jiaci.0058","article-title":"Clinical practice guidelines for diagnosis and management of hypersensitivity reactions to contrast media","volume":"26","author":"Rosado Ingelmo","year":"2016","journal-title":"J Investig Allergol Clin Immunol"},{"key":"2024062814422388400_ytae259-B2","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jaip.2022.02.004","article-title":"Drug-induced hypersensitivity syndrome (DIHS)\/drug reaction with eosinophilia and systemic symptoms (DRESS): clinical features and pathogenesis","volume":"10","author":"Hama","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"2024062814422388400_ytae259-B3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.clindermatol.2020.06.008","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome","volume":"38","author":"Cardones","year":"2020","journal-title":"Clin Dermatol"},{"key":"2024062814422388400_ytae259-B4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13223-023-00774-7","article-title":"DRESS syndrome due to iodinated contrast media. 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