{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:24:43Z","timestamp":1762957483456,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008375","name":"University of Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stiftung f\u00fcr Herzschrittmacher und Elektrophysiologie"},{"DOI":"10.13039\/100009736","name":"Freiwillige Akademische Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004362","name":"Swiss Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson&Johnson","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000555","name":"BMS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["33CS30_148474","33CS30_177520","32473B_176178","32003B_197524"],"award-info":[{"award-number":["33CS30_148474","33CS30_177520","32473B_176178","32003B_197524"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007555","name":"Foundation for Cardiovascular Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007555","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005035","name":"Biotronik","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Machaon Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We report endocardial radiofrequency (RF) ablation as an alternative treatment approach for a symptomatic patient with obstructive hypertrophic cardiomyopathy (oHCM), who is not suitable for surgical septal myectomy or alcohol septal ablation. Endocardial RF ablation, with detailed 3D mapping of the intrinsic conducting system, offers the possibility of reducing the risk of complete heart block rates and of effectively relieving symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>We present a symptomatic 51-year-old female patient with oHCM and a maximum left ventricular outflow tract (LVOT) gradient of 148 mmHg. Because of alcohol septal ablation failure, endocardial RF ablation in combination with detailed mapping of the intrinsic conduction system and intraprocedural imaging was performed. The 6-month follow-up showed a significant improvement in exercise tolerance, no relevant dynamic LVOT obstruction with a gradient of 22 mmHg under Valsalva.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>In the current case report, endocardial RF ablation persistently reduced LVOT gradients in a patient with oHCM. Pre-interventional imaging, detailed 3D mapping of the conduction system, and correlation to intracardiac and transthoracic echocardiography were key for an effective and safe ablation of a small target zone.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae359","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T00:55:42Z","timestamp":1721436942000},"source":"Crossref","is-referenced-by-count":3,"title":["Radiofrequency ablation in obstructive hypertrophic cardiomyopathy: a case report"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9335-0064","authenticated-orcid":false,"given":"Jasmin","family":"B\u00fcchel","sequence":"first","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel , Petersgraben 4, 4031 Basel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Leibundgut","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel , Petersgraben 4, 4031 Basel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-0557","authenticated-orcid":false,"given":"Patrick","family":"Badertscher","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel , Petersgraben 4, 4031 Basel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-3711","authenticated-orcid":false,"given":"Michael","family":"K\u00fchne","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel , Petersgraben 4, 4031 Basel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-2363","authenticated-orcid":false,"given":"Philipp","family":"Krisai","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel , Petersgraben 4, 4031 Basel , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"2024080614013691200_ytae359-B1","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1016\/S0140-6736(21)00763-7","article-title":"Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"397","author":"Spertus","year":"2021","journal-title":"Lancet"},{"key":"2024080614013691200_ytae359-B2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1161\/CIRCRESAHA.116.309348","article-title":"Hypertrophic obstructive cardiomyopathy: surgical myectomy and septal ablation","volume":"121","author":"Nishimura","year":"2017","journal-title":"Circ Res"},{"key":"2024080614013691200_ytae359-B3","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1161\/CIRCULATIONAHA.114.011580","article-title":"Surgical septal myectomy versus alcohol septal ablation","volume":"130","author":"Maron","year":"2014","journal-title":"Circulation"},{"key":"2024080614013691200_ytae359-B4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijcard.2020.01.021","article-title":"Multidisciplinary evaluation and management of obstructive hypertrophic cardiomyopathy in 2020: towards the HCM Heart Team","volume":"304","author":"Pelliccia","year":"2020","journal-title":"Int J Cardiol"},{"key":"2024080614013691200_ytae359-B5","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.hrthm.2016.04.018","article-title":"Radiofrequency septal reduction in symptomatic hypertrophic obstructive cardiomyopathy","volume":"13","author":"Crossen","year":"2016","journal-title":"Heart Rhythm"},{"key":"2024080614013691200_ytae359-B6","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.jacc.2022.02.032","article-title":"Survival following alcohol septal ablation or septal myectomy for patients with obstructive hypertrophic cardiomyopathy","volume":"79","author":"Cui","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2024080614013691200_ytae359-B7","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0140-6736(16)31321-6","article-title":"Hypertrophic obstructive cardiomyopathy","volume":"389","author":"Veselka","year":"2017","journal-title":"Lancet"},{"key":"2024080614013691200_ytae359-B8","first-page":"245","article-title":"Alcohol septal ablation for obstructive hypertrophic cardiomyopathy","volume":"11","author":"Sorajja","year":"2022","journal-title":"Interv Cardiol Clin"},{"key":"2024080614013691200_ytae359-B9","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jacc.2010.07.055","article-title":"Endocardial radiofrequency ablation for hypertrophic obstructive cardiomyopathy: acute results and 6 months\u2019 follow-up in 19 patients","volume":"57","author":"Lawrenz","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2024080614013691200_ytae359-B10","doi-asserted-by":"crossref","first-page":"743044","DOI":"10.3389\/fcvm.2021.743044","article-title":"Selective interventricular septal radiofrequency ablation in patients with hypertrophic obstructive cardiomyopathy: who can benefit?","volume":"8","author":"Liu","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"2024080614013691200_ytae359-B11","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/clc.23341","article-title":"Efficacy and safety of radiofrequency ablation for hypertrophic obstructive cardiomyopathy: a systematic review and meta-analysis","volume":"43","author":"Yang","year":"2020","journal-title":"Clin Cardiol"},{"key":"2024080614013691200_ytae359-B12","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1001\/jamacardio.2016.0252","article-title":"Hospital volume outcomes after septal myectomy and alcohol septal ablation for treatment of obstructive hypertrophic cardiomyopathy: US nationwide inpatient database, 2003\u20132011","volume":"1","author":"Kim","year":"2016","journal-title":"JAMA Cardiol"},{"key":"2024080614013691200_ytae359-B13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/europace\/euv302","article-title":"Radiofrequency ablation of the interventricular septum to treat outflow tract gradients in hypertrophic obstructive cardiomyopathy: a novel use of CARTOSound\u00ae technology to guide ablation","volume":"18","author":"Cooper","year":"2015","journal-title":"Europace"},{"key":"2024080614013691200_ytae359-B14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jacc.2022.04.048","article-title":"Myosin inhibition in patients with obstructive hypertrophic cardiomyopathy referred for septal reduction therapy","volume":"80","author":"Desai","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2024080614013691200_ytae359-B15","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(20)31792-X","article-title":"Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"396","author":"Olivotto","year":"2020","journal-title":"Lancet"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytae359\/58618306\/ytae359.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/8\/ytae359\/58742737\/ytae359.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/8\/ytae359\/58742737\/ytae359.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T18:59:36Z","timestamp":1722970776000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytae359\/7718475"}},"subtitle":[],"editor":[{"given":"Edgar Francisco Carrizales","family":"Sepulveda","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Aiste Monika","family":"Jakstaite","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Belinda","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Polyvios","family":"Demetriades","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytae359","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,7,23]]},"article-number":"ytae359"}}