{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T09:36:28Z","timestamp":1758274588717,"version":"3.41.2"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>An uncommon cause of reflex syncope is carotid sinus syndrome (CSS). In rare cases, this can be caused by compression of the carotid sinus by a progressive or invasive tumour.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 57-year-old female was presented at the emergency department with recurrent syncope in the morning. After initial observation, no heart rhythm abnormalities or syncope were observed. The day after discharge, she was presented again with a syncope. Hypotension and bradycardia were observed this time. Furthermore, a mass in the neck area was found near the carotid artery. She was admitted to the cardiology department with suspected carotid sinus syndrome for telemetric observation. Diagnostics by biopsy and PET-CT showed a metastasized squamous cell carcinoma of the tongue. Initial treatment of dexamethasone was started after which the recurrence of the syncope decreased. However, during admission, an in-hospital cardiac arrest occurred due to persistent vagal stimulation. As a result, the patient was started on neoadjuvant chemotherapy and midodrine, after which she experienced multiple complications and died.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>To the best of our knowledge, this is the first case report that shows an IHCA due to severe hypotension related to a carotid sinus syndrome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae393","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T07:32:22Z","timestamp":1724052742000},"source":"Crossref","is-referenced-by-count":2,"title":["Severe hypotension requiring resuscitation in tumour-related carotid sinus syndrome: a case report"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5845-3225","authenticated-orcid":false,"given":"Martijn G","family":"Klingenberg","sequence":"first","affiliation":[{"name":"Department of Cardiology, Medisch Centrum Leeuwarden , Henti Dunantlaan 2, Leeuwarden 8934 AD , Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steef J","family":"Sinkeler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medisch Centrum Leeuwarden , Henti Dunantlaan 2, Leeuwarden 8934 AD , Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Koopmans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medisch Centrum Leeuwarden , Henti Dunantlaan 2, Leeuwarden 8934 AD , Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin E","family":"Plaat","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medisch Centrum Leeuwarden , Henti Dunantlaan 2, Leeuwarden 8934 AD , Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"2024082316351046300_ytae393-B1","first-page":"837","article-title":"ESC guidelines for the diagnosis and management of syncope","volume":"71","author":"Brignole","year":"2018","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"2024082316351046300_ytae393-B2","doi-asserted-by":"crossref","first-page":"e16998","DOI":"10.1097\/MD.0000000000016998","article-title":"Treatment of syncope in tongue cancer with palliative chemotherapy in the intensive care unit: a case report","volume":"98","author":"Fang","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"2024082316351046300_ytae393-B3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1532-5415.2005.53021.x","article-title":"Treatment of vasodepressor carotid sinus syndrome with midodrine: a randomized, controlled pilot study","volume":"53","author":"Moore","year":"2005","journal-title":"J Am Geriatr Soc"},{"volume-title":"Statpearls [Internet]","year":"2022","author":"Kharsa","key":"2024082316351046300_ytae393-B4"},{"key":"2024082316351046300_ytae393-B5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1055\/s-0029-1220204","article-title":"Glossopharyngeal and limited vagal neurectomy for cancer-related carotid sinus syncope","volume":"19","author":"Lin","year":"2009","journal-title":"Skull Base"},{"key":"2024082316351046300_ytae393-B6","doi-asserted-by":"crossref","first-page":"e235066","DOI":"10.1136\/bcr-2020-235066","article-title":"Feasibility and effectiveness of palliative intensity-modulated radiotherapy for carotid sinus syndrome secondary to recurrent head and neck cancer","volume":"13","author":"Wada","year":"2020","journal-title":"BMJ Case Rep"},{"key":"2024082316351046300_ytae393-B7","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1245\/s10434-022-12694-8","article-title":"Docetaxel, cisplatin, and 5-FU triplet therapy as conversion therapy for locoregionally advanced unresectable esophageal squamous cell carcinoma","volume":"30","author":"Chan","year":"2023","journal-title":"Ann Surg Oncol"},{"key":"2024082316351046300_ytae393-B8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12871-016-0255-5","article-title":"A case of asystole from carotid sinus hypersensitivity during patient positioning for thyroidectomy","volume":"16","author":"Lilitsis","year":"2016","journal-title":"BMC Anesthesiol"}],"container-title":["European Heart Journal - 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