{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T02:21:59Z","timestamp":1764210119404,"version":"3.41.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Marfan syndrome is a genetic connective tissue disorder that commonly affects the cardiovascular, skeletal, and ocular system. The increased risk of developing thoracic aortic aneurysms that can lead to aortic dissection and rupture is the main source of mortality in these patients. Pregnancy-induced changes can further increase the risk for aortic complications, especially in patients with an aortic root diameter &amp;gt; 45\u2005mm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>The case of a 26-year-old female with Marfan syndrome who was lost to follow-up for five years and presented to our department being pregnant at 21 weeks is presented. Echocardiography and cardiovascular magnetic resonance (CMR) showed an aortic root diameter of 55\u2005mm and a large aneurysm of an aberrant right subclavian artery. Following multidisciplinary team discussion, valve-sparing aortic root and ascending aortic replacement was performed at 22 weeks of gestation without any complications. During the remaining pregnancy, the patient had frequent clinical and CMR follow-up investigations showing a mild increased size of the subclavian aneurysm. Uncomplicated caesarean delivery was performed at 35 weeks of gestation, and the subclavian artery aneurysm was successfully treated by interventional embolization.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Although cardiovascular surgery in our patient during pregnancy was uncomplicated, the case illustrates that pre-pregnancy counselling in Marfan patients is recommended to reduce the risk for mother and child.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae411","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T17:59:23Z","timestamp":1723226363000},"source":"Crossref","is-referenced-by-count":1,"title":["Management of a pregnant woman with Marfan syndrome and aortic root and aberrant right subclavian artery aneurysm: a case report"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7406-8006","authenticated-orcid":false,"given":"Inga","family":"Voges","sequence":"first","affiliation":[{"name":"Department of Congenital Heart Disease and Paediatric Cardiology, University Hospital Schleswig-Holstein , Arnold-Heller-Str. 3, Campus Kiel, 24105 Kiel , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Paediatric Cardiology, University Hospital Schleswig-Holstein , Arnold-Heller-Str. 3, Campus Kiel, 24105 Kiel , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-2106","authenticated-orcid":false,"given":"Tim","family":"Attman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein , Kiel , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8504-0228","authenticated-orcid":false,"given":"Anselm","family":"Uebing","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Paediatric Cardiology, University Hospital Schleswig-Holstein , Arnold-Heller-Str. 3, Campus Kiel, 24105 Kiel , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"2024082122561283300_ytae411-B1","doi-asserted-by":"crossref","first-page":"e004052","DOI":"10.1161\/JAHA.116.004052","article-title":"Aortic complications associated with pregnancy in Marfan syndrome: the NHLBI national registry of genetically triggered thoracic aortic aneurysms and cardiovascular conditions (GenTAC)","volume":"5","author":"Roman","year":"2016","journal-title":"J Am Heart 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and cardiovascular manifestations of heritable thoracic aortic aneurysm and dissection","volume":"32","author":"Bradley","year":"2016","journal-title":"Can J Cardiol"},{"key":"2024082122561283300_ytae411-B11","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.jacc.2023.01.005","article-title":"Prevalence and complications of aberrant subclavian artery in patients with heritable and nonheritable arteriopathies","volume":"81","author":"Giuliani","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"2024082122561283300_ytae411-B12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s11936-018-0640-0","article-title":"Preconception counseling for patients with thoracic aortic aneurysms","volume":"20","author":"Rao","year":"2018","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"2024082122561283300_ytae411-B13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jjcc.2012.11.001","article-title":"Pregnancy and delivery in cardiac 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