{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:48:45Z","timestamp":1777085325220,"version":"3.51.4"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Systemic sclerosis presents with a variety of cardiac manifestations, while myocarditis is usually a rare finding. Furthermore, there are no reports on the use of mitral transcatheter edge-to-edge repair (M-TEER) for the treatment of severe ventricular functional mitral regurgitation (vFMR) secondary to scleroderma myocarditis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A-79-year-old male was admitted to our hospital because of fever and fatigue. His physical examination revealed thickening of the fingertips\u2019 skin, Raynaud phenomenon, and mild pedal oedema. Positive anti-centromere antibodies indicated a diagnosis of a limited cutaneous systemic sclerosis. He presented with symptoms of heart failure, and moderate to severe lymphocytic infiltration was evident in his endomyocardial biopsy. He responded well to medical therapy and was discharged. However, one month after hospital discharge, he was readmitted to our institution because of worsening heart failure. Transthoracic echocardiography showed a decrease in left ventricular systolic function and progression of left ventricular remodelling, which caused severe vFMR. Endomyocardial biopsy revealed decreased lymphocytic infiltration and mild myocardial interstitial fibrosis, indicative of scleroderma myocarditis. As he was unable to be weaned off inotropes, we performed M-TEER for severe vFMR, which led to a significant reduction in MR volume and improvement of heart failure symptoms. A week after procedure, immunosuppressive therapy was initiated and the patient was discharged home in stable condition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>Scleroderma myocarditis may manifest as heart failure with reduced ejection fraction with severe vFMR. Mitral transcatheter edge-to-edge repair for severe vFMR in the context of myocarditis can be one of the therapeutic options for haemodynamic stabilization.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae425","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T18:26:12Z","timestamp":1723573572000},"source":"Crossref","is-referenced-by-count":1,"title":["Scleroderma myocarditis with severe secondary mitral regurgitation successfully treated with transcatheter edge-to-edge repair: a case report"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7714-2184","authenticated-orcid":false,"given":"Daisuke","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shonan Kamakura General Hospital , 1370-1, Okamoto, Kamakura City, Kanagawa 247-8533 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7620-4358","authenticated-orcid":false,"given":"Tomoki","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shonan Kamakura General Hospital , 1370-1, Okamoto, Kamakura City, Kanagawa 247-8533 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6603-9181","authenticated-orcid":false,"given":"Takashi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shonan Kamakura General Hospital , 1370-1, Okamoto, Kamakura City, Kanagawa 247-8533 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shonan Kamakura General Hospital , 1370-1, Okamoto, Kamakura City, Kanagawa 247-8533 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-4815","authenticated-orcid":false,"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shonan Kamakura General Hospital , 1370-1, Okamoto, Kamakura City, Kanagawa 247-8533 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"2024082809512535800_ytae425-B1","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N Engl J Med"},{"key":"2024082809512535800_ytae425-B2","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/j.jacc.2022.09.006","article-title":"Transcatheter edge-to-edge mitral valve repair in patients with severe mitral regurgitation and cardiogenic shock","volume":"80","author":"Simard","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2024082809512535800_ytae425-B3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00296-015-3382-2","article-title":"Cardiac involvement in systemic sclerosis: differences between clinical subsets and influence on survival","volume":"37","author":"Ferna\u0301ndez-Codina","year":"2017","journal-title":"Rheumatol Int"},{"key":"2024082809512535800_ytae425-B4","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"van den Hoogen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2024082809512535800_ytae425-B5","doi-asserted-by":"crossref","first-page":"e007405","DOI":"10.1161\/CIRCHEARTFAILURE.120.007405","article-title":"Management of acute myocarditis and chronic inflammatory cardiomyopathy: an expert consensus document","volume":"13","author":"Ammirati","year":"2020","journal-title":"Cir Heart Fail"},{"key":"2024082809512535800_ytae425-B6","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1001\/jama.2023.3371","article-title":"Diagnosis and treatment of acute myocarditis: a review","volume":"329","author":"Ammirati","year":"2023","journal-title":"JAMA"},{"key":"2024082809512535800_ytae425-B7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1056\/NEJM199508033330501","article-title":"A clinical trial of immunosuppressive therapy for myocarditis. 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