{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:49:28Z","timestamp":1753876168862,"version":"3.41.2"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Overdoses of carbamazepine may occur due to various reasons. The summary of product characteristics of carbamazepine includes information about the possibility of side effects after taking this drug. However, the symptoms described do not include coronary vasospasm, which occurred in the case described. Making such a diagnosis is a key element in therapeutic management, as it changes further clinical decisions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case summary<\/jats:title>\n                  <jats:p>A 46-year-old patient was admitted to the hospital for disorders of consciousness following an overdose of carbamazepine. On the second day, the patient exhibited respiratory distress. Subsequently, the patient was transferred to the intensive care unit, intubated, and placed on mechanical ventilation. On the same day, the patient experienced recurrent cardiac arrhythmias in the form of pulseless ventricular tachycardia and ventricular fibrillation; the patient was resuscitated and defibrillated eight times. Due to a rapid decline in cardiac output coupled with persistent electrocardiographic changes and haemodynamic instability, the patient underwent urgent coronary angiography. The procedure revealed a spasm in the initial segment of the circumflex branch of the left coronary artery, which subsequently resolved following nitroglycerin administration. Subsequent to the implementation of this therapeutic approach, a reduction in the demand for norepinephrine and dobutamine was achieved. In the following days, the patient's general condition improved. The patient was discharged home while maintaining full cognitive capacity and cardiovascular and respiratory fitness.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>In the case described, the expeditious performance of a cardiological diagnostic evaluation played a pivotal role in achieving therapeutic success, enabling the prompt initiation of appropriate treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ehjcr\/ytae488","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T19:58:58Z","timestamp":1725911938000},"source":"Crossref","is-referenced-by-count":1,"title":["A case report describing myocardial ischaemia as a side effect of carbamazepine overdose"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-9016","authenticated-orcid":false,"given":"Ma\u0142gorzata M","family":"Skiba","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Stefan Cardinal Wyszy\u0144ski District Specialist Hospital , Al. Kra\u015bnicka 100, Lublin 20-718 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4366-3165","authenticated-orcid":false,"given":"Mateusz","family":"Szyma\u0144ski","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Stefan Cardinal Wyszy\u0144ski District Specialist Hospital , Al. Kra\u015bnicka 100, Lublin 20-718 ,","place":["Poland"]},{"name":"Human Anatomy Department, Medical University , ul. Jaczewskiego 4, Lublin 20-090 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6432-2571","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Piasecka","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Stefan Cardinal Wyszy\u0144ski District Specialist Hospital , Al. Kra\u015bnicka 100, Lublin 20-718 ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"2024092813111161700_ytae488-B1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/bs.podrm.2015.11.001","article-title":"Carbamazepine","volume":"41","author":"Alrashood","year":"2016","journal-title":"Profiles Drug Subst Excip Relat Methodol"},{"key":"2024092813111161700_ytae488-B2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.freeradbiomed.2018.10.408","article-title":"The first-line antiepileptic drug carbamazepine: reaction with biologically relevant free radicals","volume":"129","author":"Martins","year":"2018","journal-title":"Free Radic Biol Med"},{"author":"POLPHARMA","key":"2024092813111161700_ytae488-B3"},{"key":"2024092813111161700_ytae488-B4","first-page":"3201","article-title":"A clinical study of toxication caused by carbamazepine abuse in adolescents","volume":"22","author":"Xu","year":"2018","journal-title":"Biomed Res Int"},{"key":"2024092813111161700_ytae488-B5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.reprotox.2014.10.007","article-title":"Carbamazepine toxic effects in chick cardiomyocyte micromass culture and embryonic stem cell derived cardiomyocyte systems\u2014possible protective role of antioxidants","volume":"50","author":"Qureshi","year":"2014","journal-title":"Reprod Toxicol"},{"key":"2024092813111161700_ytae488-B6","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.2169\/internalmedicine.8875-17","article-title":"A carbamazepine-induced Brugada-type electrocardiographic pattern in a patient with schizophrenia","volume":"56","author":"Ota","year":"2017","journal-title":"Intern Med"},{"key":"2024092813111161700_ytae488-B7","first-page":"143","article-title":"Kardiotoksicnost karbamazepina u akutnim trovanjima [carbamazepine cardiotoxicity in acute poisoning]","volume":"50","author":"Todorovi\u0107","year":"1993","journal-title":"Vojnosanit Preg"},{"key":"2024092813111161700_ytae488-B8","first-page":"499","article-title":"Kardiologiczne interakcje karbamazepiny z atypowymi lekami przeciwpsychotycznymi. Opis przypadku ostrego zatrucia mieszanego karbamazepina i kwetiapina [cardiologic interaction carbamazepine with atypical neuroleptics. Acute mixed carbamazepine and quetiapine intoxication\u2013case report]","volume":"68","author":"Hydzik","year":"2011","journal-title":"Przegl Lek"}],"container-title":["European Heart Journal - Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ehjcr\/advance-article-pdf\/doi\/10.1093\/ehjcr\/ytae488\/59080687\/ytae488.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/9\/ytae488\/59401774\/ytae488.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ehjcr\/article-pdf\/8\/9\/ytae488\/59401774\/ytae488.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T13:11:23Z","timestamp":1727529083000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ehjcr\/article\/doi\/10.1093\/ehjcr\/ytae488\/7754898"}},"subtitle":[],"editor":[{"given":"Josip Andelo","family":"Borovac","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Alessia","family":"Gambaro","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Duplyakov","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Xaplanteris","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Elton","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ehjcr\/ytae488","relation":{},"ISSN":["2514-2119"],"issn-type":[{"type":"electronic","value":"2514-2119"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,9,1]]},"article-number":"ytae488"}}